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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Wrn
Werner syndrome RecQ like helicase
MGI:109635
41 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cdkn1atm1Led/Cdkn1atm1Led
Wrntm1Led/Wrntm1Led
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * NIH Black Swiss) 		increased tumor incidence J:68488
Terctm1Rdp/Terctm1Rdp
Wrntm1Lgu/Wrntm1Lgu
involves: 129/Sv * BALB/c * C57BL/6 * SLJ 		abnormal adipose tissue distribution J:213181
abnormal bone marrow morphology J:213181
abnormal bone ossification J:213181
abnormal bone trabecula morphology J:213181
abnormal chromosome morphology J:91715
abnormal compact bone morphology J:213181
abnormal crypts of Lieberkuhn morphology J:91715
abnormal femur morphology J:91715
abnormal osteoid morphology J:213181
abnormal skeleton physiology J:213181
alopecia J:91715
cataract J:91715
decreased body weight J:91715
decreased bone trabecula number J:213181
decreased bone volume J:213181
decreased compact bone area J:213181
decreased compact bone thickness J:91715, J:213181
decreased subcutaneous adipose tissue amount J:91715
decreased telomere length J:91715
decreased trabecular bone mass J:91715
decreased trabecular bone thickness J:213181
delayed wound healing J:91715
fragile skeleton J:91715
hyperglycemia J:91715
impaired glucose tolerance J:91715
impaired wound healing J:91715
increased bone trabecular spacing J:213181
increased circulating insulin level J:91715
increased osteosarcoma incidence J:91715
increased sarcoma incidence J:91715
kyphosis J:91715
osteoporosis J:91715, J:213181
premature aging J:91715
premature death J:91715
small gonad J:91715
small testis J:91715
Tg(Hba-x-v-Ha-ras)TG.ACLed/0
Wrntm1Led/Wrntm1Led
involves: 129 * FVB/N * Black Swiss 		increased incidence of tumors by chemical induction J:79056
increased papilloma incidence J:79056
weight loss J:79056
Trp53tm1Brd/Trp53tm1Brd
Wrntm1Led/Wrntm1Led
either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss) 		decreased tumor latency J:68488
increased tumor incidence J:68488
Trp53tm1Tyj/Trp53tm1Tyj
Wrntm1Lgu/Wrntm1Lgu
involves: 129S2/SvPas * BALB/c 		premature death J:61567
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory