Nrxn2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nrxn2
neurexin II
MGI:1096362

16 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Nrxn1^tm1Sud/Nrxn1^tm1Sud Nrxn2^tm1Sud/Nrxn2^tm1Sud involves: 129 * C57BL/6	abnormal CNS synaptic transmission	J:89452
	abnormal excitatory postsynaptic currents	J:89452
	decreased CNS synapse formation	J:89452
	postnatal lethality, incomplete penetrance	J:89452
	respiratory distress	J:89452
Nrxn1^tm1Sud/Nrxn1^tm1Sud Nrxn2^tm1Sud/Nrxn2^tm1Sud Nrxn3^tm1Sud/Nrxn3^tm1Sud involves: 129 * C57BL/6	abnormal CNS synaptic transmission	J:88641, J:89452
	abnormal GABA-mediated receptor currents	J:89452
	abnormal paired-pulse inhibition	J:89452
	abnormal synaptic depression	J:89452
	decreased CNS synapse formation	J:89452
	decreased excitatory postsynaptic current amplitude	J:89452
	decreased neurotransmitter release	J:89452
	neonatal lethality, complete penetrance	J:89452
	reduced AMPA-mediated synaptic currents	J:89452
	reduced NMDA-mediated synaptic currents	J:88641
	respiratory distress	J:89452
Nrxn1^tm2Sud/Nrxn1^tm2Sud Nrxn2^tm2Sud/Nrxn2^tm2Sud Nrxn3^tm2Sud/Nrxn3^tm2Sud involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:101977
Nrxn2^tm1Sud/Nrxn2^tm1Sud Nrxn3^tm1Sud/Nrxn3^tm1Sud involves: 129 * C57BL/6	abnormal breathing pattern	J:89452
	abnormal excitatory postsynaptic currents	J:89452
	postnatal lethality, incomplete penetrance	J:89452
	premature death	J:89452

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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