About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Psmb10
proteasome (prosome, macropain) subunit, beta type 10
MGI:1096380
28 phenotypes from 2 alleles in 5 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Psmb10tm1Mgro/Psmb10tm1Mgro
involves: 129S2/SvPas * C57BL/6 		abnormal CD8-positive, alpha-beta cytotoxic T cell morphology J:125058
abnormal cytotoxic T cell physiology J:125058
decreased CD8-positive, alpha-beta T cell number J:125058
decreased T cell proliferation J:125058
Psmb10tm1Mgro/Psmb10Tub6
involves: 129S2/SvPas * C3HeB/FeJ 		decreased NK cell number J:261081
decreased T cell number J:261081
increased granulocyte number J:261081
premature death J:261081
Psmb10Tub6/Psmb10+
C3HeB/FeJ-Psmb10Tub6 		abnormal T cell activation J:261081
decreased CD4-positive, alpha-beta T cell number J:261081
decreased CD8-positive, alpha-beta T cell number J:261081
decreased interferon-gamma secretion J:261081
decreased T cell number J:261081
increased susceptibility to bacterial infection induced morbidity/mortality J:261081
Psmb10Tub6/Psmb10Tub6
B6.C3Fe-Psmb10Tub6 		increased granulocyte number J:261081
Psmb10Tub6/Psmb10Tub6
C3HeB/FeJ-Psmb10Tub6 		absent lymph nodes J:261081
absent spleen white pulp J:261081
absent subcutaneous adipose tissue J:261081
alopecia J:261081
athymia J:261081
decreased B cell number J:261081
decreased body size J:261081
decreased immunoglobulin level J:261081
decreased leukocyte cell number J:261081
decreased NK cell number J:261081
decreased spleen red pulp amount J:261081
decreased T cell number J:261081
hyperkeratosis J:261081
increased circulating interleukin-1 level J:261081
increased circulating interleukin-6 level J:261081
increased circulating tumor necrosis factor level J:261081
increased granulocyte number J:261081
increased inflammatory response J:261081
premature death J:261081
skin inflammation J:261081
Psmb10Tub6/Psmb10Tub6
C.C3Fe-Psmb10Tub6 		increased granulocyte number J:261081
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory