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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nrxn3
neurexin III
MGI:1096389
16 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nrxn1tm1Sud/Nrxn1tm1Sud
Nrxn2tm1Sud/Nrxn2tm1Sud
Nrxn3tm1Sud/Nrxn3tm1Sud
involves: 129 * C57BL/6 		abnormal CNS synaptic transmission J:88641, J:89452
abnormal GABA-mediated receptor currents J:89452
abnormal paired-pulse inhibition J:89452
abnormal synaptic depression J:89452
decreased CNS synapse formation J:89452
decreased excitatory postsynaptic current amplitude J:89452
decreased neurotransmitter release J:89452
neonatal lethality, complete penetrance J:89452
reduced AMPA-mediated synaptic currents J:89452
reduced NMDA-mediated synaptic currents J:88641
respiratory distress J:89452
Nrxn1tm2Sud/Nrxn1tm2Sud
Nrxn2tm2Sud/Nrxn2tm2Sud
Nrxn3tm2Sud/Nrxn3tm2Sud
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:101977
Nrxn2tm1Sud/Nrxn2tm1Sud
Nrxn3tm1Sud/Nrxn3tm1Sud
involves: 129 * C57BL/6 		abnormal breathing pattern J:89452
abnormal excitatory postsynaptic currents J:89452
postnatal lethality, incomplete penetrance J:89452
premature death J:89452
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory