Hcn1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hcn1
hyperpolarization activated cyclic nucleotide gated potassium channel 1
MGI:1096392

28 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hcn1^em1(IMPC)H/Hcn1^em1(IMPC)H C57BL/6N-Hcn1^em1(IMPC)H/H	abnormal auditory brainstem response	J:211773
	abnormal gait	J:211773
	abnormal locomotor behavior	J:211773
	decreased exploration in new environment	J:211773
	decreased heart rate	J:211773
	decreased locomotor activity	J:211773
	increased heart weight	J:211773
	prolonged RR interval	J:211773
	tremors	J:211773
Hcn1^M1Btlr/Hcn1^M1Btlr C57BL/6J-Hcn1^M1Btlr	decreased heart rate	J:267552
Hcn1^tm1.1Lex/Hcn1^tm1.1Lex 129S/SvEvBrd-Hcn1^tm1.1Lex	abnormal nervous system electrophysiology	J:176560
Hcn1^tm1.1Lex/Hcn1^tm1.1Lex 129S/SvEvBrd-Hcn1^tm1.1Lex	abnormal pain threshold	J:176560
Hcn1^tm1Kndl/Hcn1^tm1Kndl involves: 129S/SvEv * C57BL/6	no abnormal phenotype detected	J:86763
Hcn1^tm1Kndl/Hcn1^tm1Kndl Tg(Camk2a-cre)2Szi/? involves: 129S/SvEv * C57BL/6 * CBA	normal behavior/neurological phenotype	J:86763
Hcn1^tm2Kndl/Hcn1^tm2Kndl involves: 129 * 129S/SvEv * C57BL/6J * C57BL/6N	abnormal heartbeat	J:219164
	abnormal RR interval	J:219164
	abnormal sinoatrial node conduction	J:219164
	decreased cardiac output	J:219164
	increased heart rate variability	J:219164
	sinoatrial block	J:219164
	sinus bradycardia	J:219164
Hcn1^tm2Kndl/Hcn1^tm2Kndl involves: 129S/SvEv * C57BL/6	abnormal action potential	J:188823
	abnormal eye blink conditioning behavior	J:86763
	abnormal learning/memory/conditioning	J:86763
	abnormal motor learning	J:86763
	abnormal myocardial fiber physiology	J:188823
	abnormal spatial learning	J:86763
	normal behavior/neurological phenotype	J:86763
	increased thigmotaxis	J:86763
Hcn1^tm2Kndl/Hcn1^tm2Kndl involves: 129S/SvEv * C57BL/6J	abnormal depression-related behavior	J:173355

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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