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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Irf4
interferon regulatory factor 4
MGI:1096873
51 phenotypes from 6 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ighg1tm1(cre)Cgn/Ighg1+
Irf4tm1Rdf/Irf4tm1.1Rdf
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 		abnormal class switch recombination J:112643
abnormal memory B cell morphology J:112643
absent plasma cells J:112643
decreased IgG1 level J:112643
normal immune system phenotype J:112643
Irf4em1(IMPC)Mbp/Irf4em1(IMPC)Mbp
C57BL/6N-Irf4em1(IMPC)Mbp/MbpMmucd 		abnormal lymph node morphology J:211773
abnormal spleen morphology J:211773
abnormal startle reflex J:211773
abnormal thymus morphology J:211773
decreased lymphocyte cell number J:211773
enlarged lymph nodes J:211773
enlarged spleen J:211773
enlarged thymus J:211773
increased neutrophil cell number J:211773
increased spleen weight J:211773
Irf4m1Btlr/Irf4m1Btlr
C57BL/6J-Irf4m1Btlr 		abnormal B cell activation J:160882
decreased IgG level J:160882
decreased IgM level J:160882
Irf4m1Btlr/Irf4m1Btlr
involves: C57BL/6J 		abnormal class switch recombination J:185495
decreased IgG level J:185495
decreased IgM level J:185495
normal immune system phenotype J:185495
Irf4M2Btlr/Irf4+
C57BL/6J-Irf4M2Btlr 		abnormal B cell activation J:234245
decreased IgG level J:234245
decreased IgM level J:234245
Irf4M2Btlr/Irf4M2Btlr
C57BL/6J-Irf4M2Btlr 		abnormal B cell activation J:234245
decreased IgG level J:234245
decreased IgM level J:234245
Irf4tm1.1Rdf/Irf4tm1.1Rdf
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 		abnormal B cell differentiation J:112643
abnormal B cell physiology J:112643
absent spleen germinal center J:112643
decreased B cell proliferation J:112643
decreased IgG1 level J:112643
Irf4tm1Mak/Irf4tm1Mak
B6.129P2-Irf4tm1Mak 		abnormal CD4-positive, alpha beta T cell morphology J:78909
abnormal T-helper 1 cell differentiation J:78909
increased susceptibility to bacterial infection J:78909
Irf4tm1Mak/Irf4tm1Mak
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:42683
abnormal immune system cell morphology J:42683
abnormal immune system physiology J:42683
abnormal lymph node morphology J:42683
abnormal spleen morphology J:42683
abnormal tumor susceptibility J:42683
absent lymph node germinal center J:42683
absent plasma cells J:42683
absent spleen germinal center J:42683
arrested B cell differentiation J:42683
decreased B cell proliferation J:42683
decreased dendritic cell number J:91043
decreased immunoglobulin level J:42683
decreased T cell proliferation J:42683
enlarged lymph nodes J:42683
enlarged spleen J:42683
normal immune system phenotype J:169863
increased lymphocyte cell number J:42683
increased susceptibility to Riboviria infection J:42683
Irf4tm1Mak/Irf4tm1Mak
involves: 129P2/OlaHsd * C57BL/6 		decreased plasmacytoid dendritic cell number J:97716
increased susceptibility to bacterial infection J:81744
Irf4tm1Rdf/Irf4tm1.1Rdf
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 		normal immune system phenotype J:112643
Irf4tm1Rdf/Irf4tm1.1Rdf
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 		abnormal B cell physiology J:112643
Irf4tm1Rdf/Irf4tm1Rdf
Tg(Ucp1-cre)1Evdr/0
involves: 129S1/Sv * C57BL/6J * FVB 		abnormal adipose tissue development J:214637
abnormal cellular respiration J:214637
decreased carbon dioxide production J:214637
decreased core body temperature J:214637
decreased fatty acid oxidation J:214637
decreased oxygen consumption J:214637
impaired adaptive thermogenesis J:214637
impaired glucose tolerance J:214637
impaired lipolysis J:214637
increased body fat mass J:214637
increased body weight J:214637
increased epididymal fat pad weight J:214637
increased inguinal fat pad weight J:214637
increased white fat cell size J:214637
insulin resistance J:214637
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory