Wdfy3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Wdfy3
WD repeat and FYVE domain containing 3
MGI:1096875

58 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Wdfy3^disc/Wdfy3⁺ involves: C57BL/6J * FVB/NJ	no abnormal phenotype detected	J:225200
Wdfy3^disc/Wdfy3^disc involves: C57BL/6J * FVB/NJ	abnormal cell cycle	J:225200
	abnormal cerebral cortex morphology	J:225200
	abnormal cortical intermediate zone morphology	J:225200
	abnormal embryonic/fetal subventricular zone morphology	J:225200
	abnormal forebrain development	J:225200
	abnormal lateral ganglionic eminence morphology	J:225200
	abnormal medial ganglionic eminence morphology	J:225200
	abnormal neocortex morphology	J:225200
	abnormal neuronal migration	J:225200
	abnormal neuronal precursor proliferation	J:225200
	abnormal somatosensory cortex morphology	J:225200
	abnormal stratification in cerebral cortex	J:225200
	absent subplate	J:225200
	normal cellular phenotype	J:225200
	decreased cortical ventricular zone thickness	J:225200
	decreased neuronal precursor cell number	J:225200
	ectopic cortical neuron	J:225200
	enlarged lateral ventricles	J:225200
	enlarged third ventricle	J:225200
	increased forebrain size	J:225200
	increased neocortex size	J:225200
	increased radial glial cell number	J:225200
	perinatal lethality, complete penetrance	J:225200
	premature neuronal precursor differentiation	J:225200
	small olfactory bulb	J:225200
	thin cerebral cortex	J:225200
Wdfy3^em1(IMPC)Mbp/Wdfy3⁺ C57BL/6N-Wdfy3^em1(IMPC)Mbp/MbpMmucd	abnormal kidney morphology	J:211773
	abnormal liver morphology	J:211773
	abnormal lymph node morphology	J:211773
	abnormal spleen morphology	J:211773
	enlarged liver	J:211773
	enlarged lymph nodes	J:211773
	enlarged spleen	J:211773
	small kidney	J:211773
Wdfy3^em1(IMPC)Mbp/Wdfy3^em1(IMPC)Mbp C57BL/6N-Wdfy3^em1(IMPC)Mbp/MbpMmucd	abnormal blood vessel morphology	J:211773
	abnormal craniofacial morphology	J:211773
	abnormal facial morphology	J:211773
	abnormal placenta morphology	J:211773
	cleft palate	J:211773
	edema	J:211773
	embryonic growth retardation	J:211773
	preweaning lethality, complete penetrance	J:211773
Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3⁺ C57BL/6N-Wdfy3^{tm1a(KOMP)Mbp}	abnormal neocortex morphology	J:225200
Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3^{tm1a(KOMP)Mbp} C57BL/6N-Wdfy3^{tm1a(KOMP)Mbp}	abnormal cerebral cortex morphology	J:225200
	abnormal cerebral hemisphere morphology	J:225200
	abnormal forebrain development	J:225200
	abnormal neocortex morphology	J:225200
	abnormal neuronal migration	J:225200
	abnormal stratification in cerebral cortex	J:225200
	ectopic cortical neuron	J:225200
	perinatal lethality, complete penetrance	J:225200
	thin cerebral cortex	J:225200
Wdfy3^{tm1c(KOMP)Mbp}/Wdfy3^{tm1c(KOMP)Mbp} C57BL/6N-Wdfy3^{tm1c(KOMP)Mbp}	no abnormal phenotype detected	J:225200
Wdfy3^{Tn(pb-Act-RFP)1.1Zhu}/Wdfy3^{Tn(pb-Act-RFP)1.1Zhu} involves: C57BL/6 * FVB/NJ	abnormal fetal cardiomyocyte morphology	J:285853
	abnormal heart development	J:285853
	abnormal heart morphology	J:285853
	abnormal trabecula carnea morphology	J:285853
	normal cellular phenotype	J:285853
	cyanosis	J:285853
	decreased birth body size	J:285853
	decreased fetal weight	J:285853
	dilated heart ventricle	J:285853
	double outlet right ventricle	J:285853
	edema	J:285853
	overriding aortic valve	J:285853
	pallor	J:285853
	perimembraneous ventricular septal defect	J:285853
	perinatal lethality, complete penetrance	J:285853
	prenatal lethality, incomplete penetrance	J:285853
	thin ventricular wall	J:285853

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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