Fxn Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fxn
frataxin
MGI:1096879

24 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Fxn^tm1.1Pand/Fxn^tm1Mkn B6.Cg-Fxn^tm1.1Pand Fxn^tm1Mkn/J	abnormal mitochondrial biogenesis	J:242978
Fxn^tm1Mkn/Fxn^tm1Mkn Tg(FXN)YG8Pook/0 involves: 129/Sv * C57BL/6 * CBA	abnormal action potential	J:114840
	abnormal axon morphology	J:114840
	abnormal dorsal root ganglion morphology	J:114840
	abnormal enzyme/coenzyme activity	J:114840
	abnormal lumbar dorsal root ganglion morphology	J:114840
	abnormal myocardial fiber morphology	J:114840
	abnormal respiratory electron transport chain	J:114840
	brain inflammation	J:216422
	chromatolysis	J:114840
	decreased locomotor activity	J:114840
	decreased nerve conduction velocity	J:114840
	impaired coordination	J:114840
	increased body weight	J:114840
	normal mortality/aging	J:114840
	normal nervous system phenotype	J:114840
	neuron degeneration	J:114840
	oxidative stress	J:114840
Fxn^tm1Mkn/Fxn^tm1Mkn Tg(FXN)YG22Pook/0 involves: 129/Sv * C57BL/6 * CBA	abnormal dorsal root ganglion morphology	J:114840
	abnormal enzyme/coenzyme level	J:114840
	chromatolysis	J:114840
	decreased grip strength	J:114840
	decreased locomotor activity	J:114840
	impaired coordination	J:114840
	increased body weight	J:114840
	increased heart iron level	J:114840
	increased susceptibility to weight gain	J:114840
	normal mortality/aging	J:114840
	normal nervous system phenotype	J:114840
	neuron degeneration	J:114840
	oxidative stress	J:114840
Fxn^tm1Mkn/Fxn^tm1Pand involves: 129/Sv * C57BL/6	brain inflammation	J:216422
	cardiac fibrosis	J:109164
	increased heart iron level	J:109164
	premature death	J:109164

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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