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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bak1
BCL2-antagonist/killer 1
MGI:1097161
51 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bak1tm1Thsn/Bak1+
Bcl2l1tm1Dlo/Bcl2l1+
B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn 		abnormal platelet morphology J:149205
Bak1tm1Thsn/Bak1+
Bcl2l1Plt20/Bcl2l1+
involves: 129 * BALB/c * C57BL/6 		abnormal platelet morphology J:149205
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm1Sjk
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6 		abnormal B cell morphology J:66872
abnormal brain morphology J:66872
abnormal definitive hematopoiesis J:66872
abnormal hearing physiology J:66872
abnormal splenocyte physiology J:66872
abnormal T cell morphology J:66872
anemia J:66872
circling J:66872
decreased cellular sensitivity to gamma-irradiation J:66872
decreased physiological sensitivity to xenobiotic J:66872
enlarged lymph nodes J:66872
enlarged spleen J:66872
increased brain size J:66872
increased leukocyte cell number J:66872
increased lymphocyte cell number J:66872
increased neuron number J:66872
increased spleen red pulp amount J:66872
increased spleen white pulp amount J:66872
interdigital webbing J:66872
neonatal lethality, incomplete penetrance J:66872
seizures J:66872
thrombocytopenia J:66872
vagina atresia J:66872
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm1Sjk
involves: 129S1/Sv * 129X1/SvJ 		normal hematopoietic system phenotype J:141545
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(MMTV-cre)#Mam/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB 		normal hematopoietic system phenotype J:141545
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal B cell number J:100463
abnormal B cell physiology J:100463
decreased marginal zone B cell number J:100463
increased B cell number J:100463
increased B-2 B cell number J:100463
increased bone marrow cell number J:100463
increased follicular B cell number J:100463
increased IgA level J:100463
increased IgG level J:100463
increased IgM level J:100463
increased immunoglobulin level J:100463
increased pre-B cell number J:100463
increased pro-B cell number J:100463
increased transitional stage B cell number J:100463
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Krastm4Tyj/Kras+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		increased adenocarcinoma incidence J:125101
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal T cell differentiation J:100463
autoimmune arthritis J:100463
glomerulonephritis J:100463
increased anti-double stranded DNA antibody level J:100463
increased B cell number J:100463
increased leukocyte cell number J:100463
increased lymphocyte cell number J:100463
increased susceptibility to autoimmune disorder J:100463
premature death J:100463
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm2Sjk/Baxtm2Sjk
Tg(Lck-cre)1Cwi/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		decreased thymocyte apoptosis J:220951
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm2Sjk/Baxtm2Sjk
Tg(Lck-cre)548Jxm/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		increased regulatory T cell number J:208318
Bak1tm1Thsn/Bak1tm1Thsn
Bcl2l1tm1Dlo/Bcl2l1+
B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn 		abnormal platelet physiology J:149205
thrombocytosis J:149205
Hax1tm1Jni/Hax1tm1Jni
Bak1tm1Thsn/Bak1tm1Thsn
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		premature death J:132627
Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Bak1tm1Thsn/Bak1tm1Thsn
Tg(Lck-cre)1Cwi/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		normal immune system phenotype J:220951
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory