C3ar1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

C3ar1
complement component 3a receptor 1
MGI:1097680

42 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
C3ar1^{tm1.1(KOMP)Vlcg}/C3ar1^{tm1.1(KOMP)Vlcg} C57BL/6N-C3ar1^{tm1.1(KOMP)Vlcg}/Tcp	abnormal kidney morphology	J:211773
	polycystic kidney	J:211773
C3ar1^tm1Cge/C3ar1^tm1Cge B6.129S4(C)-C3ar1^tm1Cge	abnormal c-wave shape	J:214214
	abnormal retina horizontal cell morphology	J:214214
	abnormal retina rod bipolar cell morphology	J:214214
	decreased a-wave amplitude	J:214214
	decreased b-wave amplitude	J:214214
	decreased circulating free fatty acids level	J:214214
	decreased circulating phospholipid level	J:214214
	disorganized retina outer nuclear layer	J:214214
	increased retina apoptosis	J:214214
	increased susceptibility to age-related retinal degeneration	J:214214
	thin retina inner nuclear layer	J:214214
	thin retina outer nuclear layer	J:214214
C3ar1^tm1Cge/C3ar1^tm1Cge involves: 129S4/SvJae * BALB/c	decreased airway responsiveness	J:64378
C3ar1^tm1Cge/C3ar1^tm1Cge involves: 129S4/SvJae * BALB/c	normal mortality/aging	J:64378
C3ar1^tm1Cge/C3ar1^tm1Cge involves: 129S4/SvJae * C57BL/6	decreased circulating interleukin-6 level	J:166640
C3ar1^tm1Cge/C3ar1^tm1Cge involves: 129S4/SvJae * C57BL/6	decreased osteoclast cell number	J:166640
C3ar1^tm1Dgen/C3ar1^tm1Dgen involves: 129P2/OlaHsd	abnormal fat pad morphology	J:148831
C3ar1^tm1Dgen/C3ar1^tm1Dgen involves: 129P2/OlaHsd	abnormal lean body mass	J:148831
C3ar1^tm1Raw/C3ar1⁺ involves: 129X1/SvJ * C57BL/6	abnormal immune system physiology	J:68807
C3ar1^tm1Raw/C3ar1⁺ involves: 129X1/SvJ * C57BL/6	increased susceptibility to induced morbidity/mortality	J:68807
C3ar1^tm1Raw/C3ar1^tm1Raw B6.129X1(B6)-C3ar1^tm1Raw	abnormal adaptive immunity	J:80071
	abnormal eosinophil physiology	J:80071
	abnormal interleukin level	J:80071
	abnormal respiratory mucosa goblet cell morphology	J:80071
	abnormal T-helper 2 cell differentiation	J:80071
	abnormal T-helper 2 physiology	J:80071
	decreased airway responsiveness	J:80071
	decreased eosinophil cell number	J:80071
	decreased IgE level	J:80071
	decreased IgG1 level	J:80071
	decreased interleukin-4 secretion	J:80071
	decreased lymphocyte cell number	J:80071
	decreased neutrophil cell number	J:80071
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:93791
	demyelination	J:93791
	impaired liver regeneration	J:91917
	impaired neutrophil recruitment	J:80071
	increased circulating interleukin-1 beta level	J:93791
	increased susceptibility to type I hypersensitivity reaction	J:80071
C3ar1^tm1Raw/C3ar1^tm1Raw involves: 129X1/SvJ * C57BL/6	normal hematopoietic system phenotype	J:68807
	increased circulating interleukin-1 beta level	J:68807
	increased susceptibility to endotoxin shock	J:68807
	increased susceptibility to induced morbidity/mortality	J:68807
	normal mortality/aging	J:68807

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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