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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		C3ar1
complement component 3a receptor 1
MGI:1097680
42 phenotypes from 4 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
C3ar1tm1.1(KOMP)Vlcg/C3ar1tm1.1(KOMP)Vlcg
C57BL/6N-C3ar1tm1.1(KOMP)Vlcg/Tcp 		abnormal kidney morphology J:211773
polycystic kidney J:211773
C3ar1tm1Cge/C3ar1tm1Cge
B6.129S4(C)-C3ar1tm1Cge 		abnormal c-wave shape J:214214
abnormal retina horizontal cell morphology J:214214
abnormal retina rod bipolar cell morphology J:214214
decreased a-wave amplitude J:214214
decreased b-wave amplitude J:214214
decreased circulating free fatty acids level J:214214
decreased circulating phospholipid level J:214214
disorganized retina outer nuclear layer J:214214
increased retina apoptosis J:214214
increased susceptibility to age-related retinal degeneration J:214214
thin retina inner nuclear layer J:214214
thin retina outer nuclear layer J:214214
C3ar1tm1Cge/C3ar1tm1Cge
involves: 129S4/SvJae * BALB/c 		decreased airway responsiveness J:64378
normal mortality/aging J:64378
C3ar1tm1Cge/C3ar1tm1Cge
involves: 129S4/SvJae * C57BL/6 		decreased circulating interleukin-6 level J:166640
decreased osteoclast cell number J:166640
C3ar1tm1Dgen/C3ar1tm1Dgen
involves: 129P2/OlaHsd 		abnormal fat pad morphology J:148831
abnormal lean body mass J:148831
C3ar1tm1Raw/C3ar1+
involves: 129X1/SvJ * C57BL/6 		abnormal immune system physiology J:68807
increased susceptibility to induced morbidity/mortality J:68807
C3ar1tm1Raw/C3ar1tm1Raw
B6.129X1(B6)-C3ar1tm1Raw 		abnormal adaptive immunity J:80071
abnormal eosinophil physiology J:80071
abnormal interleukin level J:80071
abnormal respiratory mucosa goblet cell morphology J:80071
abnormal T-helper 2 cell differentiation J:80071
abnormal T-helper 2 physiology J:80071
decreased airway responsiveness J:80071
decreased eosinophil cell number J:80071
decreased IgE level J:80071
decreased IgG1 level J:80071
decreased interleukin-4 secretion J:80071
decreased lymphocyte cell number J:80071
decreased neutrophil cell number J:80071
decreased susceptibility to experimental autoimmune encephalomyelitis J:93791
demyelination J:93791
impaired liver regeneration J:91917
impaired neutrophil recruitment J:80071
increased circulating interleukin-1 beta level J:93791
increased susceptibility to type I hypersensitivity reaction J:80071
C3ar1tm1Raw/C3ar1tm1Raw
involves: 129X1/SvJ * C57BL/6 		normal hematopoietic system phenotype J:68807
increased circulating interleukin-1 beta level J:68807
increased susceptibility to endotoxin shock J:68807
increased susceptibility to induced morbidity/mortality J:68807
normal mortality/aging J:68807
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory