Bhlhe40 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bhlhe40
basic helix-loop-helix family, member e40
MGI:1097714

35 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Bhlhe40^tm1.1Rhli/Bhlhe40^tm1.1Rhli involves: 129S1/Sv * C57BL/6 * CD-1 * SJL	increased susceptibility to pharmacologically induced seizures	J:131834
Bhlhe40^{tm1b(KOMP)Wtsi}/Bhlhe40^{tm1b(KOMP)Wtsi} B6N(Cg)-Bhlhe40^{tm1b(KOMP)Wtsi}/J	decreased fasting circulating glucose level	J:211773
	increased heart weight	J:211773
Bhlhe40^{tm1b(KOMP)Wtsi}/Bhlhe40^{tm1b(KOMP)Wtsi} C57BL/6N-Bhlhe40^{tm1b(KOMP)Wtsi}/Wtsi	decreased circulating calcium level	J:211773
	decreased circulating cholesterol level	J:211773
	decreased circulating glycerol level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	increased blood urea nitrogen level	J:211773
	increased circulating chloride level	J:211773
	increased circulating fructosamine level	J:211773
	increased circulating iron level	J:211773
	increased mean corpuscular hemoglobin	J:211773
Bhlhe40^tm1Tan/Bhlhe40^tm1Tan B6.129-Bhlhe40^tm1Tan	delayed circadian behavior phase	J:138240
Bhlhe40^tm1Tan/Bhlhe40^tm1Tan either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal CD4-positive T cell differentiation	J:72651
	abnormal CD4-positive, alpha-beta T cell physiology	J:72651
	abnormal immune system cell morphology	J:72651
	abnormal immune system physiology	J:72651
	abnormal lymph node germinal center morphology	J:72651
	abnormal renal glomerulus morphology	J:72651
	abnormal susceptibility to autoimmune disorder	J:72651
	abnormal T cell activation	J:72651
	decreased double-positive T cell number	J:72651
	decreased interleukin-2 secretion	J:72651
	decreased T cell proliferation	J:72651
	increased anti-nuclear antigen antibody level	J:72651
	increased CD4-positive, alpha-beta T cell number	J:72651
	increased CD8-positive, alpha-beta T cell number	J:72651
	increased double-negative T cell number	J:72651
	increased IgE level	J:72651
	increased IgG1 level	J:72651
	increased spleen germinal center number	J:72651
	increased spleen white pulp amount	J:72651
	lymph node hyperplasia	J:72651
	spleen hyperplasia	J:72651
	thymus hyperplasia	J:72651

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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