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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ifnar2
interferon (alpha and beta) receptor 2
MGI:1098243
17 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ifnar2m1Btlr/Ifnar2m1Btlr
C57BL/6J-Ifnar2m1Btlr 		abnormal macrophage physiology J:147329
decreased interferon-alpha secretion J:147329
decreased interferon-beta secretion J:147329
increased susceptibility to Adenoviridae infection J:147329
increased susceptibility to Herpesvirales infection J:147329
increased susceptibility to Orthomyxoviridae infection J:147329
increased susceptibility to Riboviria infection J:147329
Ifnar2tm1Pjh/Ifnar2tm1Pjh
B6.Cg-Ifnar2tm1Pjh 		decreased NK cell number J:125812
impaired natural killer cell mediated cytotoxicity J:125812
increased incidence of induced tumors J:125812
increased incidence of tumors by chemical induction J:125812
Ifnar2tm1Pjh/Ifnar2tm1Pjh
involves: C57BL/6 		abnormal CD4-positive, alpha-beta T cell physiology J:132662
abnormal cytotoxic T cell physiology J:132662
decreased IgG1 level J:132662
decreased IgG2a level J:132662
decreased IgG level J:132662
decreased interferon-gamma secretion J:132662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory