Jag2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Jag2
jagged 2
MGI:1098270

42 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Jag2^sm/Jag2^sm involves: A/Fa	abnormal apical ectodermal ridge morphology	J:12940
	abnormal autopod morphology	J:12940
	abnormal caudal vertebrae morphology	J:13049
	abnormal digit development	J:13049
	abnormal limb bud morphology	J:5107, J:12940
	abnormal tail morphology	J:13049
	epidermal hyperplasia	J:12940
	female infertility	J:13049
	fused phalanges	J:13049
	fused tarsal bones	J:13049
	kinked tail	J:13049
	parakeratosis	J:12940
	perinatal lethality, incomplete penetrance	J:13049
	postnatal lethality, incomplete penetrance	J:13049
	syndactyly	J:13049
	thick apical ectodermal ridge	J:5107
Jag2^{tm1b(KOMP)Wtsi}/Jag2^{tm1b(KOMP)Wtsi} C57BL/6N-Jag2^{tm1b(KOMP)Wtsi}/H	preweaning lethality, complete penetrance	J:211773
Jag2^tm1Grid/Jag2⁺ involves: 129S1/Sv * C57BL/6J	increased cochlear hair cell number	J:53432
Jag2^tm1Grid/Jag2⁺ involves: 129S1/Sv * C57BL/6J	increased cochlear inner hair cell number	J:53432
Jag2^tm1Grid/Jag2^tm1Grid involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J	abnormal orientation of cochlear hair cell stereociliary bundles	J:132241
	increased cochlear inner hair cell number	J:132241
	increased cochlear outer hair cell number	J:132241
	postnatal lethality, complete penetrance	J:132241
Jag2^tm1Grid/Jag2^tm1Grid involves: 129S1/Sv * C57BL/6J	abnormal cochlear outer hair cell morphology	J:62727
	abnormal embryonic autopod plate morphology	J:46930
	abnormal gamma-delta T cell differentiation	J:46930
	abnormal orientation of inner hair cell stereociliary bundles	J:53432
	abnormal phalanx morphology	J:46930
	abnormal thymus medulla morphology	J:46930
	abnormal thymus morphology	J:46930
	absent maxillary shelf	J:46930
	absent palatine bone horizontal plate	J:46930
	bilateral cleft palate	J:46930
	cleft secondary palate	J:46930
	cyanosis	J:46930
	decreased gamma-delta T cell number	J:46930
	decreased organ of Corti supporting cell number	J:53432
	failure of palatal shelf elevation	J:46930
	increased cochlear hair cell number	J:53432, J:62727
	increased cochlear inner hair cell number	J:53432, J:62727
	increased cochlear outer hair cell number	J:53432, J:62727
	palatal shelf fusion with tongue or mandible	J:46930
	perinatal lethality, complete penetrance	J:46930
	respiratory distress	J:46930
	syndactyly	J:46930
	thick apical ectodermal ridge	J:46930
Jag2^tm2.2Grid/Jag2^tm2.2Grid involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	cleft palate	J:163652
	neonatal lethality, complete penetrance	J:163652
	palatal shelf fusion with tongue or mandible	J:163652
	syndactyly	J:163652

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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