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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cyp27b1
cytochrome P450, family 27, subfamily b, polypeptide 1
MGI:1098274
61 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cyp27b1tm1.1Star/Cyp27b1tm1.1Star
involves: 129S1/Sv * 129X1/SvJ 		abnormal femur morphology J:82529
decreased bone mineralization J:82529
rickets J:82529
Cyp27b1tm1b(EUCOMM)Hmgu/Cyp27b1tm1b(EUCOMM)Hmgu
C57BL/6N-Cyp27b1tm1b(EUCOMM)Hmgu/Tcp 		abnormal bone structure J:211773
abnormal clavicle morphology J:211773
abnormal cranium morphology J:211773
abnormal femur morphology J:211773
abnormal fibula morphology J:211773
abnormal humerus morphology J:211773
abnormal joint morphology J:211773
abnormal pelvic girdle bone morphology J:211773
abnormal radius morphology J:211773
abnormal rib morphology J:211773
abnormal scapula morphology J:211773
abnormal tibia morphology J:211773
abnormal ulna morphology J:211773
abnormal vertebrae morphology J:211773
decreased body length J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased circulating calcium level J:211773
decreased circulating phosphate level J:211773
decreased exploration in new environment J:211773
decreased grip strength J:211773
decreased leukocyte cell number J:211773
decreased locomotor activity J:211773
decreased lymphocyte cell number J:211773
decreased total body fat amount J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating bilirubin level J:211773
short tibia J:211773
Cyp27b1tm1Dgo/Cyp27b1tm1Dgo
involves: 129S1/Sv * 129X1/SvJ * BALB/c 		abnormal blood homeostasis J:70030
abnormal ovarian folliculogenesis J:70030
absent corpus luteum J:70030
absent estrous cycle J:70030
absent mature ovarian follicles J:70030
anovulation J:70030
decreased body weight J:70030
decreased bone mineralization J:70030
decreased circulating calcium level J:70030
decreased circulating phosphate level J:70030
decreased osteoclast cell number J:70030
decreased T cell number J:70030
endometrium hypoplasia J:70030
enlarged lymph nodes J:70030
female infertility J:70030
increased circulating alkaline phosphatase level J:70030
increased circulating parathyroid hormone level J:70030
increased urine phosphate level J:70030
normal integument phenotype J:70030
postnatal growth retardation J:70030
small ovary J:70030
small uterus J:70030
thickened long bone epiphysis J:70030
Cyp27b1tm1Hfd/Cyp27b1tm1Hfd
involves: 129S7/SvEvBrd * C57BL/6 		rickets J:97370
Cyp27b1tm1Star/Cyp27b1tm1Star
involves: 129S1/Sv * 129X1/SvJ 		abnormal blood homeostasis J:71928
abnormal bone mineralization J:90983, J:90984
abnormal long bone metaphysis morphology J:71928
decreased body size J:71928
decreased bone mineral density of femur J:71928
decreased bone mineralization J:71928
decreased circulating calcium level J:71928, J:78635
decreased circulating phosphate level J:71928
disorganized long bone epiphyseal plate J:71928
enlarged parathyroid gland J:71928
increased circulating alkaline phosphatase level J:71928
increased circulating parathyroid hormone level J:71928
increased long bone epiphyseal plate size J:71928
normal integument phenotype J:71928, J:71937
osteomalacia J:71928
postnatal growth retardation J:71928
rickets J:71928
slow postnatal weight gain J:71928
Cyp27b1tm1Star/Cyp27b1tm1Star
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal keratinocyte differentiation J:89330
decreased body size J:89330
impaired skin barrier function J:89330
postnatal growth retardation J:89330
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory