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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Crebbp
CREB binding protein
MGI:1098280
148 phenotypes from 12 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
CrebbpGt(U-San)112Imeg/Crebbp+
involves: C57BL/6 * CBA 		abnormal cell differentiation J:75361
abnormal embryonic growth/weight/body size J:53370
abnormal heart morphology J:53370
abnormal tumor necrosis factor level J:75361
atrial septal defect J:53370
broad nasal bridge J:53370
decreased body weight J:75361
decreased circulating free fatty acids level J:75361
decreased fat cell size J:75361
decreased locomotor activity J:53370
decreased percent body fat/body weight J:75361
decreased susceptibility to diet-induced obesity J:75361
decreased triglyceride level J:75361
decreased vertical activity J:53370
decreased white adipose tissue amount J:75361
delayed bone ossification J:53370
impaired long-term object recognition memory J:53370
improved glucose tolerance J:75361
increased circulating adiponectin level J:75361
increased circulating insulin level J:75361
increased circulating leptin level J:75361
increased insulin sensitivity J:75361
increased oxygen consumption J:75361
increased response to leptin J:75361
large anterior fontanelle J:53370
maxilla hypoplasia J:53370
nasal bone hypoplasia J:53370
normal nervous system phenotype J:53370
oligodactyly J:53370
perimembraneous ventricular septal defect J:53370
postnatal lethality J:53370
scoliosis J:53370
seizures J:53370
short maxilla J:53370
short premaxilla J:53370
short snout J:53370
wide frontal bone J:53370
CrebbpGt(U-San)112Imeg/CrebbpGt(U-San)112Imeg
involves: C57BL/6 * CBA 		abnormal blood vessel morphology J:54568
abnormal extraembryonic tissue morphology J:54568
abnormal vascular development J:53370, J:54568
abnormal vascular endothelial cell development J:53370
abnormal vasculogenesis J:54568
absent organized vascular network J:54568
absent vitelline blood vessels J:54568
anemia J:54568
decreased angiogenesis J:54568
decreased embryo size J:54568
decreased vascular endothelial cell number J:54568
embryonic growth arrest J:54568
embryonic lethality during organogenesis, complete penetrance J:54568
failure of vascular branching J:54568
impaired hematopoiesis J:54568
open neural tube J:54568
pale yolk sac J:54568
pallor J:54568
Crebbptm1.1Ltz/Crebbp+
involves: 129P2/OlaHsd * C57BL/6N 		abnormal nervous system morphology J:93192
decreased body size J:93192
premature death J:93192
Crebbptm1.1Ltz/Crebbp+
involves: 129P2/OlaHsd * C57BL/6N * CD-1 		premature death J:93192
Crebbptm1.1Ltz/Crebbptm1.1Ltz
involves: 129P2/OlaHsd * C57BL/6N 		prenatal lethality J:93192
Crebbptm1.2Ltz/Crebbptm1.2Ltz
Tg(Camk2a-cre)T29-1Stl/0
involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J 		abnormal behavior J:168984
normal behavior/neurological phenotype J:168984
impaired long-term object recognition memory J:168984
normal nervous system phenotype J:168984
Crebbptm1Dli/Crebbp+
involves: 129S6/SvEvTac * C57BL/6 		abnormal common myeloid progenitor cell morphology J:191503
abnormal craniofacial morphology J:60630
abnormal definitive hematopoiesis J:60630, J:191503
abnormal granulocyte morphology J:191503
abnormal leukocyte morphology J:191503
abnormal megakaryocyte morphology J:191503
absent pre-B cells J:60630
decreased B cell number J:60630
decreased body weight J:191503
decreased common myeloid progenitor cell number J:60630, J:191503
decreased hematopoietic stem cell number J:191503
decreased lymphocyte cell number J:191503
enlarged spleen J:60630, J:191503
extramedullary hematopoiesis J:60630
increased bone marrow cell number J:191503
increased cellular sensitivity to gamma-irradiation J:191503
increased granulocyte number J:191503
increased hemolymphoid system tumor incidence J:60630
increased histiocytic sarcoma incidence J:60630
increased leukemia incidence J:60630
increased megakaryocyte cell number J:191503
postnatal growth retardation J:60630
Crebbptm1Dli/Crebbptm1Dli
involves: 129S6/SvEvTac * C57BL/6 		embryonic lethality, complete penetrance J:60630
open neural tube J:60630
Crebbptm1Few/Crebbp+
Not Specified 		abnormal glucose homeostasis J:91133
abnormal pancreatic beta cell morphology J:91133
decreased circulating glucagon level J:91133
impaired glucose tolerance J:91133
increased circulating glucose level J:91133
increased circulating insulin level J:91133
increased liver glycogen level J:91133
insulin resistance J:91133
Crebbptm1Few/Crebbptm1Few
Not Specified 		abnormal glucose homeostasis J:91133
abnormal pancreatic beta cell morphology J:91133
decreased circulating glucagon level J:91133
impaired glucose tolerance J:91133
increased circulating glucose level J:91133
increased circulating insulin level J:91133
increased liver glycogen level J:91133
Crebbptm1Jvd/Crebbptm1Jvd
involves: 129 * C57BL/6 		no abnormal phenotype detected J:88323
Crebbptm1Jvd/Crebbptm1Jvd
Tg(Lck-cre)548Jxm/0
involves: 129 * C57BL/6 * CBA 		decreased CD4-positive, alpha-beta T cell number J:105505
decreased T cell number J:105505
decreased thymocyte number J:105505
increased double-positive T cell number J:105505
increased T cell derived lymphoma incidence J:105505
small thymus J:105505
Crebbptm1Jvd/Crebbptm1Jvd
Tg(MMTV-cre)4Mam/0
involves: 129 * C57BL/6 * FVB 		decreased double-positive T cell number J:88323
increased CD8-positive, alpha-beta T cell number J:88323
increased T cell derived lymphoma incidence J:88323
Crebbptm1Ltz/Crebbptm1Ltz
involves: 129P2/OlaHsd * C57BL/6N 		no abnormal phenotype detected J:93192
Crebbptm1Pkb/Crebbptm1Pkb
involves: 129P2/OlaHsd * C57BL/6 		decreased body size J:98329
decreased thymocyte number J:98329
postnatal lethality, incomplete penetrance J:98329
Crebbptm1Reck/Crebbp+
involves: 129P2/OlaHsd 		abnormal heart development J:85949
embryonic lethality during organogenesis, incomplete penetrance J:85949
lethality throughout fetal growth and development, incomplete penetrance J:85949
normal muscle phenotype J:85950
postnatal lethality J:85949
postnatal lethality, complete penetrance J:85950
thin ventricle myocardium compact layer J:85949
Crebbptm1Sis/Crebbp+
involves: BALB/cCrSlc * C57BL/6NCrlj * CBA/JNCrlj 		abnormal joint morphology J:42932
abnormal limb morphology J:42932
abnormal rib morphology J:42932
abnormal sternum morphology J:42932
abnormal vertebrae morphology J:42932
cardiovascular system phenotype J:42932, J:63763
delayed bone ossification J:42932
large anterior fontanelle J:42932
postnatal growth retardation J:42932
prenatal lethality, incomplete penetrance J:42932, J:63763
scoliosis J:42932
xiphoid process foramen J:42932
Crebbptm1Sis/Crebbp+
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal sternum morphology J:42932
large anterior fontanelle J:42932
postnatal growth retardation J:42932
xiphoid process foramen J:42932
Crebbptm1Sis/Crebbptm1Sis
involves: BALB/cCrSlc * C57BL/6NCrlj * CBA/JNCrlj 		abnormal blood vessel morphology J:63763
abnormal extraembryonic tissue morphology J:63763
abnormal forebrain morphology J:63763
abnormal neural tube morphology J:63763
abnormal spinal cord morphology J:63763
abnormal vasculogenesis J:63763
decreased angiogenesis J:63763
decreased embryo size J:63763
embryonic growth retardation J:63763
embryonic lethality during organogenesis, complete penetrance J:63763
embryonic lethality, complete penetrance J:42932
exencephaly J:63763
impaired hematopoiesis J:63763
incomplete rostral neuropore closure J:63763
intracranial hemorrhage J:63763
open neural tube J:63763
pale yolk sac J:63763
pallor J:63763
Crebbptm2Pkb/Crebbp+
involves: 129P2/OlaHsd * C57BL/6 		preweaning lethality, incomplete penetrance J:103607
Crebbptm2Pkb/Crebbptm2Pkb
(B6.129-Crebbptm2Pkb x 129-Crebbptm2Pkb)F1 		abnormal craniofacial morphology J:103607
perinatal lethality, incomplete penetrance J:103607
postnatal growth retardation J:103607
Crebbptm2Pkb/Crebbptm2Pkb
(B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1 		abnormal nest building behavior J:230850
abnormal occipital bone morphology J:230850
abnormal social investigation J:230850
decreased aggression towards male mice J:230850
decreased anxiety-related response J:230850
decreased body size J:230850
decreased grip strength J:230850
flattened snout J:230850
impaired coordination J:230850
impaired long-term object recognition memory J:230850
increased grooming behavior J:230850
increased locomotor activity J:230850
increased post-tetanic potentiation J:230850
increased stereotypic behavior J:230850
increased vertical activity J:230850
normal mortality/aging J:230850
short nasal bone J:230850
split xiphoid process J:230850
supernumerary teeth J:230850
Crebbptm2Pkb/Crebbptm2Pkb
involves: 129P2/OlaHsd * C57BL/6 		abnormal lung interstitium morphology J:103607
abnormal pulmonary alveolus morphology J:103607
cleft secondary palate J:103607
perinatal lethality, incomplete penetrance J:103607
small lung J:103607
Tg(Camk2a-Crebbp*)1364Tabe/0
involves: C57BL/6 * SJL 		abnormal contextual conditioning behavior J:121812
abnormal spatial learning J:121812
normal behavior/neurological phenotype J:121812
increased thigmotaxis J:121812
reduced long-term potentiation J:121812
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory