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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rif1
replication timing regulatory factor 1
MGI:1098622
23 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rif1Gt(A045A01)Wrst/Rif1Gt(A045A01)Wrst
involves: 129S2/SvPas * C57BL/6J 		abnormal mitosis J:155449
decreased cell proliferation J:155449
embryonic lethality during organogenesis, incomplete penetrance J:155449
postnatal growth retardation J:155449
postnatal lethality, incomplete penetrance J:155449
reduced fertility J:155449
Rif1Gt(XT0278)Wtsi/Rif1Gt(XT0278)Wtsi
involves: 129P2/OlaHsd * CD-1 * MF1 		abnormal class switch recombination J:195061
abnormal DNA repair J:195061
abnormal double-strand DNA break repair J:195061
decreased IgA level J:195061
decreased IgG1 level J:195061
decreased IgG2b level J:195061
decreased IgG3 level J:195061
decreased IgG level J:195061
normal immune system phenotype J:195061
increased cellular sensitivity to ionizing radiation J:195061
increased susceptibility to bacterial infection J:195061
preweaning lethality, complete penetrance J:195061
preweaning lethality, incomplete penetrance J:195061
Rif1Gt(XT0278)Wtsi/Rif1Gt(XT0278)Wtsi
involves: 129P2/OlaHsd * MF1 		embryonic growth retardation J:195061
preweaning lethality, complete penetrance J:195061
Rif1MommeD18/Rif1+
Tg(HBA1-GFP)1Ew/Tg(HBA1-GFP)1Ew
involves: C57BL/6J * FVB/N 		abnormal epigenetic regulation of gene expression J:201508
Rif1tm1.1Sbcb/Rif1tm1.1Sbcb
involves: C57BL/6 * C57BL/6J 		decreased cell proliferation J:155449
Rif1tm2Sbcb/Rif1tm2Sbcb
involves: C57BL/6J 		embryonic lethality, complete penetrance J:155449
Rif1tm3.1Sbcd/Rif1tm3.1Sbcd
involves: C57BL/6 * C57BL/6J 		no abnormal phenotype detected J:188030
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory