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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tet1
tet methylcytosine dioxygenase 1
MGI:1098693
52 phenotypes from 6 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
B6.129P2-Tet1Gt(RRG140)Byg 		abnormal double-strand DNA break repair J:194101
abnormal embryo development J:243754
abnormal female meiosis J:194101
abnormal synaptonemal complex J:194101
absent ovary J:194101
decreased birth body size J:243754
decreased litter size J:194101
decreased oocyte number J:194101
decreased ovary weight J:194101
increased female germ cell apoptosis J:194101
increased ovary apoptosis J:194101
prenatal lethality, incomplete penetrance J:194101, J:243754
normal reproductive system phenotype J:194101
small ovary J:194101
Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
involves: 129P2/OlaHsd * C57BL/6 * CD-1 		preweaning lethality, complete penetrance J:243754
Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
involves: 129P2/OlaHsd * C57BL/6J 		abnormal embryo development J:243754
abnormal head fold morphology J:243754
embryonic lethality during organogenesis, complete penetrance J:243754
embryonic lethality, complete penetrance J:194101
excessive folding of visceral yolk sac J:243754
Tet1tm1.1Gxu/Tet1tm1.1Gxu
involves: 129 * 129P2/OlaHsd * C57BL/6J 		abnormal iron homeostasis J:315675
abnormal iron level J:315675
decreased intestinal iron level J:315675
decreased spleen iron level J:315675
increased circulating iron level J:315675
increased liver iron level J:315675
increased pancreas iron level J:315675
Tet1tm1.1Gxu/Tet1tm1.1Gxu
involves: 129 * C57BL/6J 		abnormal temporal memory J:201001
impaired spatial learning J:201001
normal nervous system phenotype J:201001
Tet1tm1.1Gxu/Tet1tm1.1Gxu
Tg(Nes-EGFP)33Enik/0
involves: 129 * BALB/cBy * C57BL/6 * C57BL/6J 		abnormal DNA methylation J:201001
abnormal neuronal precursor proliferation J:201001
Tet1tm1.1Jae/Tet1tm1.1Jae
involves: 129S4/SvJae * C57BL/6 		decreased birth body size J:175858
decreased body size J:175858
decreased litter size J:175858
decreased neutrophil cell number J:175858
embryonic growth retardation J:175858
Tet1tm1Gxu/Tet1tm1.1Gxu
Tg(Nes-cre/ERT2)KEisc/0
involves: 129 * C57BL/6J 		abnormal neuron differentiation J:201001
abnormal neuronal precursor proliferation J:201001
Tet1tm1Gxu/Tet1tm1Gxu
involves: 129 * C57BL/6J 		abnormal neuronal precursor proliferation J:201001
Tet1tm1Koh/Tet1tm1Koh
B6.Cg-Tet1tm1Koh 		abnormal forebrain development J:243754
incomplete rostral neuropore closure J:243754
Tet1tuft/Tet1tuft
3H1/Lznf-Tet1tuft 		abnormal interfrontal bone morphology J:242827
abnormal lamina terminalis morphology J:242827
abnormal lateral ventricle morphology J:242827
abnormal neural tube closure J:242825
abnormal paraventricular hypothalamic nucleus morphology J:242827
abnormal supraoptic nucleus morphology J:242827
anencephaly J:242825
bifid nose J:242825
decreased body length J:242825
decreased body weight J:242825
encephalomeningocele J:242825
increased lipoma incidence J:242827
irregular coat pigmentation J:242827
midline facial cleft J:242825, J:242827
ocular hypertelorism J:242825, J:242827
Tet1tuft/Tet1tuft
involves: 3H1/Lznf * BALB/c 		abnormal interfrontal bone morphology J:242827
increased lipoma incidence J:242827
ocular hypertelorism J:242827
Tet1tuft/Tet1tuft
involves: 3H1/Lznf * M. m. castaneus 		increased lipoma incidence J:242827
ocular hypertelorism J:242827
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory