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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
MGI:1099800
41 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nfkb1tm1Bal/Nfkb1tm1Bal
Nfkb2tm1Sbn/Nfkb2tm1Sbn
involves: 129P2/OlaHsd * 129S4/SvJae 		abnormal bone marrow cavity morphology J:45119
abnormal immune system organ morphology J:45119
abnormal long bone morphology J:45119
abnormal macrophage physiology J:45119
abnormal osteoclast differentiation J:45119
abnormal spleen morphology J:45119
abnormal thymus cortex morphology J:45119
abnormal thymus medulla morphology J:45119
absent lymph nodes J:45119
absent spleen white pulp J:45119
arrested B cell differentiation J:45119
decreased B cell number J:45119
decreased CD4-positive, alpha-beta T cell number J:45119
decreased CD8-positive, alpha-beta T cell number J:45119
decreased dendritic cell number J:45119
decreased double-positive T cell number J:45119
decreased length of long bones J:45119
decreased mature B cell number J:45119
decreased osteoclast cell number J:45119
decreased single-positive T cell number J:45119
decreased T cell number J:45119
failure of tooth eruption J:45119
increased granulocyte number J:45119
increased macrophage cell number J:45119
osteopetrosis J:45119
postnatal growth retardation J:45119
premature death J:45119
thymus hypoplasia J:45119
Nfkb1tm1Brv/Nfkb1tm1Brv
Nfkb2tm1Brv/Nfkb2+
involves: 129S1/Sv * C57BL/6 		abnormal bone structure J:44112
abnormal osteoclast differentiation J:44112
decreased osteoclast cell number J:44112
Nfkb1tm1Brv/Nfkb1tm1Brv
Nfkb2tm1Brv/Nfkb2tm1Brv
involves: 129S1/Sv * C57BL/6 		abnormal bone marrow cavity morphology J:44112
abnormal craniofacial morphology J:44112
abnormal cytokine secretion J:44112
abnormal long bone epiphyseal plate morphology J:44112
abnormal long bone morphology J:44112
abnormal osteoclast differentiation J:44112
decreased interleukin-6 secretion J:44112
decreased osteoclast cell number J:44112
increased macrophage cell number J:44112
osteopetrosis J:44112
postnatal growth retardation J:44112
tooth impaction J:44112
Nfkb2Lym1/Nfkb2+
Otub1tm1c(EUCOMM)Hmgu/Otub1tm1c(EUCOMM)Hmgu
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/6N 		normal immune system phenotype J:280549
Nfkb2tm2Brv/Nfkb2+
Traf3tm1Bal/Traf3tm1Bal
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 		postnatal lethality, complete penetrance J:124635
Nfkb2tm2Brv/Nfkb2tm2Brv
Tg(Tnfsf13b)1Fma/?
B6.Cg-Nfkb2tm2Brv Tg(Tnfsf13b)1Fma 		abnormal B cell activation J:113556
absent spleen marginal zone J:113556
decreased marginal zone B cell number J:113556
normal immune system phenotype J:113556
increased urine protein level J:113556
Nfkb2tm2Brv/Nfkb2tm2Brv
Traf3tm1Bal/Traf3tm1Bal
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 		normal immune system phenotype J:124635
normal mortality/aging J:124635
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory