Nfkb2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
MGI:1099800

41 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Nfkb1^tm1Bal/Nfkb1^tm1Bal Nfkb2^tm1Sbn/Nfkb2^tm1Sbn involves: 129P2/OlaHsd * 129S4/SvJae	abnormal bone marrow cavity morphology	J:45119
	abnormal immune system organ morphology	J:45119
	abnormal long bone morphology	J:45119
	abnormal macrophage physiology	J:45119
	abnormal osteoclast differentiation	J:45119
	abnormal spleen morphology	J:45119
	abnormal thymus cortex morphology	J:45119
	abnormal thymus medulla morphology	J:45119
	absent lymph nodes	J:45119
	absent spleen white pulp	J:45119
	arrested B cell differentiation	J:45119
	decreased B cell number	J:45119
	decreased CD4-positive, alpha-beta T cell number	J:45119
	decreased CD8-positive, alpha-beta T cell number	J:45119
	decreased dendritic cell number	J:45119
	decreased double-positive T cell number	J:45119
	decreased length of long bones	J:45119
	decreased mature B cell number	J:45119
	decreased osteoclast cell number	J:45119
	decreased single-positive T cell number	J:45119
	decreased T cell number	J:45119
	failure of tooth eruption	J:45119
	increased granulocyte number	J:45119
	increased macrophage cell number	J:45119
	osteopetrosis	J:45119
	postnatal growth retardation	J:45119
	premature death	J:45119
	thymus hypoplasia	J:45119
Nfkb1^tm1Brv/Nfkb1^tm1Brv Nfkb2^tm1Brv/Nfkb2⁺ involves: 129S1/Sv * C57BL/6	abnormal bone structure	J:44112
	abnormal osteoclast differentiation	J:44112
	decreased osteoclast cell number	J:44112
Nfkb1^tm1Brv/Nfkb1^tm1Brv Nfkb2^tm1Brv/Nfkb2^tm1Brv involves: 129S1/Sv * C57BL/6	abnormal bone marrow cavity morphology	J:44112
	abnormal craniofacial morphology	J:44112
	abnormal cytokine secretion	J:44112
	abnormal long bone epiphyseal plate morphology	J:44112
	abnormal long bone morphology	J:44112
	abnormal osteoclast differentiation	J:44112
	decreased interleukin-6 secretion	J:44112
	decreased osteoclast cell number	J:44112
	increased macrophage cell number	J:44112
	osteopetrosis	J:44112
	postnatal growth retardation	J:44112
	tooth impaction	J:44112
Nfkb2^Lym1/Nfkb2⁺ Otub1^{tm1c(EUCOMM)Hmgu}/Otub1^{tm1c(EUCOMM)Hmgu} Cd19^tm1(cre)Cgn/Cd19⁺ involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/6N	normal immune system phenotype	J:280549
Nfkb2^tm2Brv/Nfkb2⁺ Traf3^tm1Bal/Traf3^tm1Bal involves: 129S1/Sv * 129S4/SvJae * C57BL/6	postnatal lethality, complete penetrance	J:124635
Nfkb2^tm2Brv/Nfkb2^tm2Brv Tg(Tnfsf13b)1Fma/? B6.Cg-Nfkb2^tm2Brv Tg(Tnfsf13b)1Fma	abnormal B cell activation	J:113556
	absent spleen marginal zone	J:113556
	decreased marginal zone B cell number	J:113556
	normal immune system phenotype	J:113556
	increased urine protein level	J:113556
Nfkb2^tm2Brv/Nfkb2^tm2Brv Traf3^tm1Bal/Traf3^tm1Bal involves: 129S1/Sv * 129S4/SvJae * C57BL/6	normal immune system phenotype	J:124635
	normal mortality/aging	J:124635

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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