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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fgf10
fibroblast growth factor 10
MGI:1099809
163 phenotypes from 9 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fgf10Mhdaaey17/Fgf10+
C3HeB/FeJ-Fgf10Mhdaaey17 		abnormal lens epithelium morphology J:154551
abnormal lens fiber morphology J:154551
abnormal lens morphology J:154551
Harderian gland atrophy J:154551
microphthalmia J:86685, J:154551
narrow eye opening J:154551
normal vision/eye phenotype J:154551
Fgf10Mhdaaey17/Fgf10+
involves: C3HeB/FeJ * C57BL/6 		abnormal lens fiber morphology J:154551
abnormal retina apoptosis J:154551
Fgf10Mhdaaey17/Fgf10Mhdaaey17
C3HeB/FeJ-Fgf10Mhdaaey17 		absent limbs J:154551
prenatal lethality, complete penetrance J:154551
Fgf10ptls/Fgf10ptls
involves: C57BL/6 * FVB/N 		absent limb buds J:173681
absent limbs J:173681
absent lungs J:173681
Fgf10tm1.1(cre/ERT2)Sbel/Fgf10tm1.1(cre/ERT2)Sbel
involves: C57BL/6 		absent limbs J:187831
absent lung buds J:187831
cecal atresia J:187831
colon atresia J:187831
Fgf10tm1.1Sms/Fgf10tm1.1Sms
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ 		abnormal ear morphology J:160254
abnormal embryo development J:160254
abnormal respiratory system morphology J:160254
Fgf10tm1.1Sms/Fgf10tm1.1Sms
involves: 129S1/Sv * 129X1/SvJ 		abnormal lung development J:150706
absent lungs J:150706
neonatal lethality, complete penetrance J:150706
Fgf10tm1.2Sms/Fgf10tm1.2Sms
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ 		no abnormal phenotype detected J:160254
Fgf10tm1b(EUCOMM)Wtsi/Fgf10+
C57BL/6N-Fgf10tm1b(EUCOMM)Wtsi/H 		abnormal behavior J:211773
abnormal cornea morphology J:211773
cornea opacity J:211773
decreased grip strength J:211773
decreased lean body mass J:211773
decreased leukocyte cell number J:211773
decreased locomotor activity J:211773
decreased thigmotaxis J:211773
impaired pupillary reflex J:211773
increased circulating cholesterol level J:211773
increased circulating HDL cholesterol level J:211773
increased total body fat amount J:211773
narrow eye opening J:211773
Fgf10tm1b(EUCOMM)Wtsi/Fgf10tm1b(EUCOMM)Wtsi
C57BL/6N-Fgf10tm1b(EUCOMM)Wtsi/H 		preweaning lethality, complete penetrance J:211773
Fgf10tm1Ska/Fgf10+
involves: C57BL/6 * CBA 		abnormal forced expiratory flow rates J:200882
abnormal submandibular duct morphology J:119849
decreased body weight J:200882
submandibular gland hypoplasia J:119849
Fgf10tm1Ska/Fgf10Tg(Myl3-lacZ)24Buck
involves: C57BL/6 * CBA 		abnormal colon morphology J:115048
abnormal embryonic tissue morphology J:109476
abnormal enzyme/coenzyme activity J:98521
abnormal intestinal epithelium morphology J:115048
abnormal large intestine crypts of Lieberkuhn morphology J:115048
abnormal mammary placode morphology J:109476
abnormal pulmonary elastic fiber morphology J:98521
impaired branching involved in bronchus morphogenesis J:98521
small lung J:98521
Fgf10tm1Ska/Fgf10tm1Ska
involves: C57BL/6 * CBA 		abnormal adipose tissue morphology J:108349
abnormal branching of the mammary ductal tree J:73434
abnormal cecum development J:87411, J:115048
abnormal colon morphology J:115048
abnormal embryonic tissue morphology J:109476
abnormal gastric chief cell morphology J:114183
abnormal hair follicle morphology J:114183
abnormal hair shaft morphology J:114183
abnormal heart atrium auricular region morphology J:111148
abnormal heart position or orientation J:111148
abnormal hindgut morphology J:115048
abnormal incisor morphology J:114183
abnormal inner ear morphology J:114183
abnormal intestinal epithelium morphology J:115048
abnormal kidney inner medulla morphology J:114183
abnormal kidney medulla morphology J:114183
abnormal kidney outer medulla morphology J:114183
abnormal large intestine crypts of Lieberkuhn morphology J:115048
abnormal limb bud morphology J:51966
abnormal limb development J:80685
abnormal limb muscle morphology J:80685
abnormal lung development J:80685
abnormal mammary fat pad morphology J:73434
abnormal mammary placode morphology J:73434, J:109476
abnormal metanephric ureteric bud development J:114183
abnormal neurohypophysis development J:114183
abnormal periderm development J:109476
abnormal pulmonary circulation J:111148
abnormal pulmonary trunk morphology J:111148
abnormal Rathke's pouch apoptosis J:114183
abnormal scapula morphology J:51966
abnormal stomach submucosa morphology J:114183
abnormal tooth morphology J:114183
abnormal urethra morphology J:94932
absent adenohypophysis J:114183
absent colon J:115048
absent forelimb J:51966, J:92361, J:217810
absent hindlimb J:51966, J:92361
absent humerus J:51966
absent limbs J:51966, J:94932, J:114183
absent lung buds J:51966
absent lungs J:51966, J:80685, J:92361, J:114183
absent pituitary gland J:114183
absent pulmonary artery J:111148
absent pulmonary vein J:111148
absent radius J:51966
absent Rathke's pouch J:114183
absent rectum J:92361
absent salivary gland J:114183
absent submandibular gland J:114183, J:119849
absent thyroid gland J:114183
absent ulna J:51966
cecal atresia J:92361
decreased colon length J:115048
decreased hair follicle number J:114183
decreased pancreatic beta cell number J:114183
decreased trachea gland number J:119848
dextrocardia J:111148
diaphragmatic hernia J:80685
dilated kidney calyx J:114183
eyelids open at birth J:51966
increased hair follicle apoptosis J:114183
normal muscle phenotype J:80685
pancreas fibrosis J:114183
perinatal lethality, complete penetrance J:51966
perineal hypospadia J:92361
short incisors J:114183
small hair follicle bulb J:114183
small kidney J:114183
small molars J:114183
small otic capsule J:114183
small pancreas J:114183
small stomach J:114183
small thymus J:114183
submandibular gland hypoplasia J:119849
thin skin J:114183
translucent skin J:114183
Fgf10tm1Wss/Fgf10+
involves: 129 * 129X1/SvJ * BALB/c * C57BL/6 		submandibular gland hypoplasia J:119849
Fgf10tm1Wss/Fgf10+
involves: 129X1/SvJ 		abnormal lateral nasal gland morphology J:237227
abnormal nasal gland morphology J:237227
abnormal sublingual gland morphology J:299375
abnormal submandibular gland development J:299375
decreased salivation J:299375
decreased submandibular gland size J:299375
polydipsia J:299375
reduced enamel thickness J:299375
small salivary gland J:299375
xerostomia J:299375
Fgf10tm1Wss/Fgf10tm1.1Sms
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ 		abnormal ear morphology J:160254
abnormal embryo development J:160254
abnormal respiratory system morphology J:160254
Fgf10tm1Wss/Fgf10tm1Wss
either: (involves: 129X1/SvJ) or (involves: 129X1/SvJ * Black Swiss) 		abnormal branching involved in trachea morphogenesis J:50768
abnormal lung development J:50768
abnormal pelvic girdle bone morphology J:50768
absent forelimb J:50768
absent hindlimb J:50768
absent limb buds J:50768
absent limbs J:50768
absent lungs J:50768
decreased fetal size J:50768
impaired branching involved in bronchus morphogenesis J:50768
impaired branching involved in preterminal bronchiole morphogenesis J:50768
impaired lung alveolus development J:50768
perinatal lethality, complete penetrance J:50768
Fgf10tm1Wss/Fgf10tm1Wss
involves: 129X1/SvJ 		abnormal epidermal layer morphology J:85732
abnormal lateral nasal gland morphology J:237227
abnormal male reproductive system morphology J:85295
abnormal nasal gland morphology J:237227
abnormal palatal mesenchymal cell proliferation J:90909
abnormal palate morphology J:90909
abnormal primitive urogenital sinus morphology J:85295
abnormal prostate gland morphology J:85295
abnormal secondary palate development J:90909
abnormal tongue morphology J:90909
abnormal Wolffian duct morphology J:85295
absent bulbourethral gland J:85295
absent Harderian gland J:64331
absent lacrimal glands J:64331
absent palatal rugae J:90909
absent prostate gland J:85295
absent seminal vesicle J:85295
cleft secondary palate J:90909
decreased palatal length J:90909
epididymal cyst J:85295
hypospadia J:98380
palatal shelf fusion with tongue or mandible J:90909
thin epidermis J:85732
tongue ankylosis J:90909
Fgf10tm1Wss/Fgf10tm1Wss
involves: 129X1/SvJ * C57BL/6 		abnormal cecum development J:104353
Fgf10tm1Wss/Fgf10tm1Wss
involves: 129X1/SvJ * CF-1 		abnormal cochlea morphology J:83738
abnormal crista ampullaris morphology J:83738
abnormal inner ear canal morphology J:83738
abnormal inner ear vestibule morphology J:83738
abnormal sensory neuron innervation pattern J:83738
abnormal utricle morphology J:83738
abnormal vestibular hair cell kinocilium morphology J:83738
abnormal vestibular hair cell stereociliary bundle morphology J:83738
absent posterior semicircular canal J:83738
absent superior semicircular canal J:83738
decreased lateral semicircular canal size J:83738
small ears J:83738
small vestibular saccule J:83738
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory