Fgf10 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fgf10
fibroblast growth factor 10
MGI:1099809

43 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Fgf3^tm1Mrc/Fgf3⁺ Fgf10^tm1Wss/Fgf10^tm1Wss involves: 129S7/SvEvBrd * 129X1/SvJ	small otic vesicle	J:83659
Fgf3^tm1Mrc/Fgf3^tm1Mrc Fgf10^tm1Wss/Fgf10⁺ involves: 129S7/SvEvBrd * 129X1/SvJ	abnormal otic vesicle development	J:83659
	small otic vesicle	J:83659
Fgf3^tm1Mrc/Fgf3^tm1Mrc Fgf10^tm1Wss/Fgf10^tm1Wss involves: 129S7/SvEvBrd * 129X1/SvJ	absent inner ear	J:83659
	absent limbs	J:83659
	absent otic vesicle	J:83659
	curly tail	J:83659
	short tail	J:83659
Fgf3^tm1Sng/Fgf3^tm1Sng Fgf10^tm1Ska/Fgf10^tm1Ska involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal ear development	J:87221
	absent vestibulocochlear ganglion	J:87221
	embryonic lethality during organogenesis, complete penetrance	J:87221
	small otic vesicle	J:87221
Fgf10^{tm1.1(cre/ERT2)Sbel}/Fgf10^tm1Sms Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6	abnormal cecum development	J:187831
	abnormal lung bud morphology	J:187831
	interdigital webbing	J:187831
Fgf10^tm1.1Sms/Fgf10^tm1.1Sms Fgf3^tm1.1Sms/Fgf3^tm1.1Sms involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ	absent limbs	J:160254
	absent otic vesicle	J:160254
	short tail	J:160254
	small otic vesicle	J:160254
Fgf10^tm1.2Sms/Fgf10^tm1.2Sms Fgf3^tm1.2Sms/Fgf3^tm1.2Sms involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	no abnormal phenotype detected	J:160254
Fgf10^tm1Ska/Fgf10⁺ Fgf8^tm1Moon/Fgf8^tm1Moon Mesp1^tm2(cre)Ysa/Mesp1⁺ involves: C57BL/6NCrlj * CBA/JNCrlj	aberrant origin of the right subclavian artery	J:170879
	abnormal aortic arch morphology	J:170879
	abnormal cardiac outflow tract development	J:170879
	abnormal cardiovascular development	J:170879
	abnormal common carotid artery morphology	J:170879
	abnormal fourth pharyngeal arch artery morphology	J:170879
	abnormal pharyngeal arch artery morphology	J:170879
	abnormal sixth pharyngeal arch artery morphology	J:170879
	abnormal third pharyngeal arch artery morphology	J:170879
	decreased heart right ventricle size	J:170879
	double outlet right ventricle	J:170879
	right aortic arch	J:170879
	second pharyngeal arch hypoplasia	J:170879
	third pharyngeal arch hypoplasia	J:170879
	ventricular septal defect	J:170879
Fgf10^tm1Ska/Fgf10^tm1Ska Fgf8^tm1Moon/Fgf8^tm1Moon Mesp1^tm2(cre)Ysa/Mesp1⁺ involves: C57BL/6NCrlj * CBA/JNCrlj	aberrant origin of the right subclavian artery	J:170879
	abnormal aortic arch morphology	J:170879
	abnormal cardiac epithelial to mesenchymal transition	J:170879
	abnormal cardiac neural crest cell migration	J:170879
	abnormal cardiac outflow tract development	J:170879
	abnormal cardiovascular development	J:170879
	abnormal common carotid artery morphology	J:170879
	abnormal fourth pharyngeal arch artery morphology	J:170879
	abnormal pharyngeal arch artery morphology	J:170879
	abnormal sixth pharyngeal arch artery morphology	J:170879
	abnormal third pharyngeal arch artery morphology	J:170879
	decreased heart right ventricle size	J:170879
	double outlet right ventricle	J:170879
	second pharyngeal arch hypoplasia	J:170879
	third pharyngeal arch hypoplasia	J:170879
	ventricular septal defect	J:170879
Fgf10^tm1Ska/Fgf10^tm1Sms Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Twist2^tm1(cre)Dor/Twist2⁺ involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA	abnormal lung development	J:150706
	abnormal lung lobe morphology	J:150706
	abnormal right lung accessory lobe morphology	J:150706
	abnormal right lung cranial lobe morphology	J:150706
	abnormal right lung middle lobe morphology	J:150706
	impaired branching involved in bronchus morphogenesis	J:150706
	lung hemorrhage	J:150706
	pulmonary hypoplasia	J:150706
	small lung	J:150706
	small lung lobe	J:150706
Fgf10^tm1Wss/Fgf10⁺ Fgfr2^tm2Dsn/Fgfr2⁺ Tg(Pgk1-cre)1Lni/0 involves: 129 * 129X1/SvJ * BALB/c * C57BL/6	abnormal submandibular duct morphology	J:119849
	decreased submandibular gland size	J:119849

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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