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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pkd2
polycystin 2, transient receptor potential cation channel
MGI:1099818
73 phenotypes from 12 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pkd2lrm4/Pkd2lrm4
C3.CAnN-Pkd2lrm4 		abnormal direction of embryo turning J:170490
abnormal left-right axis patterning J:170490
dextrocardia J:170490
edema J:170490
normal embryo phenotype J:170490
lethality throughout fetal growth and development, complete penetrance J:170490
right pulmonary isomerism J:170490
right-sided stomach J:170490
Pkd2lrm4/Pkd2lrm4
involves: BALB/cAnN * C3H/HeH 		abnormal stomach position or orientation J:145068
dextrocardia J:145068
edema J:145068
left pulmonary isomerism J:145068
mesocardia J:145068
right pulmonary isomerism J:145068
situs inversus J:145068
Pkd2m1Btlr/Pkd2m1Btlr
C57BL/6J-Pkd2m1Btlr 		abnormal kidney morphology J:225044
distended abdomen J:225044
polycystic kidney J:225044
Pkd2tm1.1Gwu/Pkd2tm1.1Gwu
Tg(Vil1-cre)997Gum/0
involves: C57BL/6 * C57BL/6J * SJL 		abnormal kidney morphology J:265516
enlarged kidney J:265516
increased blood urea nitrogen level J:265516
increased circulating creatinine level J:265516
increased kidney cell proliferation J:265516
kidney cyst J:265516
kidney failure J:265516
liver cyst J:265516
pancreas cyst J:265516
premature death J:265516
Pkd2tm1.1Tjwt/Pkd2tm1.1Tjwt
involves: 129S/SvEv * 129X1/SvJ * C57BL/6 * SJL 		no abnormal phenotype detected J:165114
Pkd2tm1.1Tjwt/Pkd2tm1.1Tjwt
Tg(Tek-cre)1Ywa/0
involves: 129S/SvEv * 129X1/SvJ * C57BL/6 * SJL 		abnormal placenta vasculature J:165114
hemorrhage J:165114
normal homeostasis/metabolism phenotype J:165114
perinatal lethality, incomplete penetrance J:165114
polyhydramnios J:165114
prenatal lethality, incomplete penetrance J:165114
Pkd2tm1.1Tjwt/Pkd2tm1.2Tjwt
Meox2tm1(cre)Sor/Meox2+
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL 		dextrocardia J:165114
edema J:165114
kidney cyst J:165114
neonatal lethality J:165114
pancreas cyst J:165114
situs inversus J:165114
Pkd2tm1.2Tjwt/Pkd2tm1.2Tjwt
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL 		lethality throughout fetal growth and development, complete penetrance J:165114
Pkd2tm1Dwo/Pkd2tm1Dwo
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) 		abnormal direction of embryo turning J:77401
abnormal heart development J:77401
abnormal heart looping J:77401
abnormal left-right axis patterning J:77401
abnormal liver development J:77401
abnormal lung development J:77401
abnormal pancreas morphology J:77401
absent spleen J:77401
embryonic lethality during organogenesis, complete penetrance J:77401
hemorrhage J:77401
hydrops fetalis J:77401
kidney cortex cyst J:77401
kidney cyst J:77401
pancreas cyst J:77401
situs ambiguus J:77401
situs inversus J:77401
Pkd2tm1Gwu/Pkd2tm1Gwu
involves: C57BL/6 		abnormal hepatic vein morphology J:143124
abnormal liver morphology J:143124
abnormal papillary duct morphology J:143124
dilated bile duct J:143124
dilated pancreatic duct J:143124
dilated proximal convoluted tubule J:143124
dilated renal tubule J:143124
increased glomerular capsule space J:143124
kidney cyst J:143124
liver cyst J:143124
normal mortality/aging J:143124
pancreas cyst J:143124
postnatal growth retardation J:143124
Pkd2tm1Sia/Pkd2tm1Sia
Not Specified 		abnormal primitive node morphology J:195164
embryonic lethality during organogenesis, incomplete penetrance J:195164
lethality throughout fetal growth and development, complete penetrance J:195164
Pkd2tm1Som/Pkd2+
involves: 129/Sv * C57BL/6J * SJL 		kidney cyst J:47035
Pkd2tm1Som/Pkd2tm1Som
involves: 129/Sv * C57BL/6J * SJL 		kidney cortex cyst J:47035
kidney cyst J:47035
kidney medulla cyst J:47035
liver cyst J:47035
Pkd2tm1Som/Pkd2tm2Som
involves: 129/Sv * C57BL/6J * SJL 		abnormal cholangiocyte morphology J:158354
abnormal cholangiocyte primary cilium morphology J:158354
bile duct proliferation J:47035, J:158354
enlarged kidney J:158354
enlarged liver J:158354
increased blood urea nitrogen level J:59314, J:220561
increased cholangiocyte apoptosis J:158354
increased kidney apoptosis J:158354
increased kidney cell proliferation J:158354
increased kidney weight J:158354, J:220561
increased liver weight J:158354
kidney failure J:59314
liver cyst J:47035, J:158354
liver fibrosis J:158354
pancreas cyst J:59314
polycystic kidney J:47035, J:59314, J:158354, J:220561
premature death J:59314
Pkd2tm1Tjwt/Pkd2tm1Tjwt
involves: 129S/SvEv * 129X1/SvJ 		postnatal lethality, incomplete penetrance J:165114
Pkd2tm2Som/Pkd2+
involves: 129/Sv * C57BL/6 * SJL 		liver cyst J:78422
Pkd2tm2Som/Pkd2+
involves: 129/Sv * C57BL/6J * SJL 		kidney cyst J:47035, J:59314
liver cyst J:47035, J:59314
premature death J:59314
Pkd2tm2Som/Pkd2tm2Som
involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL 		kidney cyst J:158762
lethality throughout fetal growth and development, complete penetrance J:158762
Pkd2tm2Som/Pkd2tm2Som
involves: 129/Sv * C57BL/6J * SJL 		abnormal amniotic fluid composition J:104483
abnormal placental labyrinth vasculature morphology J:104483
abnormal primitive node morphology J:107740
atrial septal defect J:59314
atrioventricular septal defect J:59314
hemorrhage J:59314
hydrops fetalis J:59314
kidney cortex cyst J:59314
lethality throughout fetal growth and development, complete penetrance J:59314
pancreas cyst J:59314
pericardial effusion J:59314
polyhydramnios J:104483
ventricular septal defect J:59314
Pkd2tm3Som/Pkd2tm3Som
Tg(Pkhd1-cre)1Igr/0
involves: 129S4/SvJae * C57BL/6 		enlarged kidney J:244067
increased blood urea nitrogen level J:244067
increased circulating creatinine level J:244067
increased kidney cell proliferation J:244067
polycystic kidney J:244067
premature death J:244067
Pkd2tm3Som/Pkd2tm3Som
Tg(Pkhd1-cre)1Igr/?
Not Specified 		abnormal mitotic spindle morphology J:185863
dilated kidney collecting duct J:185863
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11/12/2024
MGI 6.24 		The Jackson Laboratory