Tln1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tln1
talin 1
MGI:1099832

39 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tln1^tm1.1Bpet/Tln1^tm4.1Crit Tg(Pf4-icre)Q3Rsko/0 involves: 129P2/OlaHsd * C57BL/6	abnormal platelet physiology	J:177971
	reduced thrombolysis	J:177971
Tln1^tm1Crit/Tln1^tm1Crit involves: 129P2/OlaHsd * MF1	abnormal amniotic cavity morphology	J:65873
	abnormal ectoderm development	J:65873
	abnormal embryo development	J:65873
	abnormal embryonic tissue morphology	J:65873
	abnormal extraembryonic mesoderm development	J:65873
	abnormal extraembryonic tissue morphology	J:65873
	abnormal gastrulation movements	J:65873
	abnormal mesoderm development	J:65873
	abnormal trophoblast layer morphology	J:65873
	absent ectoplacental cavity	J:65873
	absent extraembryonic coelom	J:65873
	decreased embryo size	J:65873
	disorganized extraembryonic tissue	J:65873
	embryonic growth arrest	J:65873
	embryonic lethality, complete penetrance	J:65873
	embryonic-extraembryonic boundary constriction	J:65873
	small amniotic cavity	J:65873
	small proamniotic cavity	J:65873
Tln1^tm3Crit/Tln1^tm3Crit involves: 129/Sv * 129S1/Sv * 129X1/SvJ	abnormal ectoderm development	J:65873
	abnormal embryo development	J:65873
	abnormal extraembryonic tissue morphology	J:65873
	abnormal proamniotic cavity morphology	J:65873
	abnormal trophoblast layer morphology	J:65873
	decreased embryo size	J:65873
	embryonic growth arrest	J:65873
	embryonic lethality during organogenesis, complete penetrance	J:65873
	small proamniotic cavity	J:65873
Tln1^tm4.1Crit/Tln1^tm4.1Crit Tg(Mx1-cre)1Cgn/0 involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA	normal immune system phenotype	J:134784
Tln1^tm4.1Crit/Tln1^tm4.1Crit Tg(Mx1-cre)1Cgn/? involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal platelet activation	J:129708
	abnormal platelet morphology	J:129708
	abnormal platelet shape	J:129708
	abnormal thrombosis	J:129708
	increased bleeding time	J:129708
Tln1^tm4.1Crit/Tln1^tm4.1Crit Tg(Pf4-icre)Q3Rsko/? involves: 129P2/OlaHsd	abnormal megakaryocyte morphology	J:131289
	abnormal platelet activation	J:129707
	abnormal thrombosis	J:129707
	decreased hematocrit	J:129707
	decreased hemoglobin content	J:129707
	gastrointestinal hemorrhage	J:129707
	hemoperitoneum	J:129707
	increased bleeding time	J:129707
	low mean erythrocyte cell number	J:129707
	melena	J:129707
	postnatal lethality, incomplete penetrance	J:129707
	premature death	J:129707
	thrombocytopenia	J:129707
Tln1^tm4.1Crit/Tln1^tm4.1Crit Tg(Pf4-icre)Q3Rsko/0 involves: 129P2/OlaHsd * C57BL/6	reduced thrombolysis	J:177971
Tln1^tm4Crit/Tln1^tm4Crit involves: 129P2/OlaHsd * C57BL/6 * CBA	embryonic lethality between somite formation and embryo turning, complete penetrance	J:131145

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