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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfsf11
tumor necrosis factor (ligand) superfamily, member 11
MGI:1100089
125 phenotypes from 10 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(APCS-Tnfsf11*)#aKhs/0
C57BL/6J-Tg(APCS-Tnfsf11*)#aKhs 		abnormal osteoclast morphology J:264357
decreased bone mineral density of femur J:264357
decreased bone stiffness J:264357
decreased bone strength J:264357
decreased trabecular bone mass J:264357
enlarged thymus medulla J:264357
fragile skeleton J:264357
increased bone resorption J:264357
increased circulating alkaline phosphatase level J:264357
increased osteoclast cell number J:264357
osteoporosis J:264357
perinatal lethality, incomplete penetrance J:264357
postnatal lethality, incomplete penetrance J:264357
skin edema J:264357
Tg(APCS-Tnfsf11*)#bKhs/0
involves: C3H/He * C57BL/6N 		decreased trabecular bone mass J:264357
osteoporosis J:264357
Tg(CAG-Tnfsf11*)#Khs/0
either: (involves: C57BL/6N) or (involves: C3H/He * C57BL/6J) 		decreased bone mineralization J:264357
distended abdomen J:264357
perinatal lethality, complete penetrance J:264357
Tnfsf11gum/Tnfsf11gum
STOCK Tnfsf11gum/GrsrJ 		abnormal areal bone mineral density J:223062
abnormal cranial suture morphology J:223062
abnormal craniofacial bone morphology J:223062
abnormal hyoid bone body morphology J:223062
abnormal long bone internal diameter J:223062
abnormal maternal nurturing J:223062
abnormal tail length J:223062
abnormal zygomatic bone morphology J:223062
decreased body size J:223062
decreased body weight J:223062
decreased internal diameter of femur J:223062
decreased lean body mass J:223062
dystrophic muscle J:223062
failure of tooth eruption J:223062
increased areal bone mineral density J:223062
increased bone mineral content J:223062
mandible hypoplasia J:223062
osteopetrosis J:223062
reduced fertility J:223062
small cranium J:223062
supernumerary teeth J:223062
Tnfsf11tles/Tnfsf11tles
involves: 129S6/SvEvTac * C57BL/6J 		abnormal osteoblast physiology J:179743
abnormal trabecular bone morphology J:179743
absent lymph nodes J:179743
decreased osteoclast cell number J:179743
enlarged spleen J:179743
failure of tooth eruption J:179743
increased bone trabecula number J:179743
increased bone volume J:179743
osteopetrosis J:179743
postnatal growth retardation J:179743
premature death J:179743
normal skeleton phenotype J:179743
thymus hypoplasia J:179743
Tnfsf11tles/Tnfsf11tm1Pngr
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J 		abnormal trabecular bone morphology J:179743
decreased osteoclast cell number J:179743
failure of tooth eruption J:179743
increased bone mass J:179743
increased bone trabecula number J:179743
increased bone volume J:179743
osteopetrosis J:179743
Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob
Tg(BGLAP-cre)1Clem/0
involves: 129S * 129X1/SvJ * C57BL/6 * FVB/NJ 		abnormal cartilage morphology J:177558
failure of tooth eruption J:177558
increased bone mineral density J:177558
increased long bone epiphyseal plate size J:177558
increased trabecular bone volume J:177558
Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob
Tg(Col10a1-cre)1427Vdm/0
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 		increased bone mineral density J:177558
increased trabecular bone volume J:177558
osteopetrosis J:177558
Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob
Tg(Dmp1-cre)1Jqfe/0
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB 		abnormal bone structure J:177558
abnormal osteoclast cell number J:177558
decreased compact bone thickness J:177558
decreased osteoclast cell number J:177558
increased bone mineral density of femur J:177558
increased bone mineral density of vertebrae J:177558
increased bone trabecular spacing J:177558
increased trabecular bone volume J:177558
normal skeleton phenotype J:177558
Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob
Tg(Prrx1-cre)1Cjt/0
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 		abnormal cartilage morphology J:177558
decreased osteoclast cell number J:177558
increased bone mineral density J:177558
increased long bone epiphyseal plate size J:177558
increased trabecular bone volume J:177558
osteopetrosis J:177558
normal skeleton phenotype J:177558
Tnfsf11tm1.1Caob/Tnfsf11tm1.1Caob
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129S * 129X1/SvJ * C57BL/6 * CD-1 		abnormal cartilage morphology J:177558
failure of tooth eruption J:177558
increased bone mineral density J:177558
increased long bone epiphyseal plate size J:177558
increased trabecular bone volume J:177558
normal skeleton phenotype J:177558
Tnfsf11tm1.1Htaka/Tnfsf11tm1.1Htaka
B6.Cg-Tnfsf11tm1.1Htaka 		normal skeleton phenotype J:177557
Tnfsf11tm1.1Htaka/Tnfsf11tm1.2Htaka
Tg(Dmp1-cre)1Jqfe/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N 		abnormal bone ossification J:177557
abnormal cartilage morphology J:177557
decreased bone resorption J:177557
decreased osteoclast cell number J:177557
normal growth/size/body region phenotype J:177557
increased bone mass J:177557
increased bone volume J:177557
increased trabecular bone volume J:177557
osteopetrosis J:177557
normal skeleton phenotype J:177557
Tnfsf11tm1.1Htaka/Tnfsf11tm1.2Htaka
Tg(Lck-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J 		normal skeleton phenotype J:177557
Tnfsf11tm1.2Htaka/Tnfsf11+
B6.Cg-Tnfsf11tm1.2Htaka 		abnormal trabecular bone morphology J:177557
decreased osteoclast cell number J:177557
increased bone volume J:177557
Tnfsf11tm1.2Htaka/Tnfsf11tm1.2Htaka
B6.Cg-Tnfsf11tm1.2Htaka 		abnormal cartilage morphology J:177557
abnormal long bone metaphysis morphology J:177557
abnormal trabecular bone morphology J:177557
decreased body weight J:177557
decreased bone resorption J:177557
decreased length of long bones J:177557
decreased osteoclast cell number J:177557
failure of tooth eruption J:177557
increased bone volume J:177557
increased spleen weight J:177557
kyphosis J:177557
osteopetrosis J:177557
postnatal growth retardation J:177557
Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
involves: 129P2/OlaHsd 		abnormal thymus epithelium morphology J:173115
Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
involves: 129P2/OlaHsd * C57BL/6 		abnormal immune system morphology J:52369
abnormal immune system physiology J:52369
abnormal long bone epiphyseal plate morphology J:52369
abnormal mammary gland growth during pregnancy J:64718
abnormal neurocranium morphology J:52369
abnormal pro-B cell differentiation J:52369
absent mesenteric lymph nodes J:52369
absent peripheral lymph nodes J:52369
arrested T cell differentiation J:52369
decreased immature B cell number J:52369
decreased interferon-gamma secretion J:52369
decreased interleukin-2 secretion J:52369
decreased interleukin-4 secretion J:52369
decreased interleukin-5 secretion J:52369
decreased interleukin-6 secretion J:52369
decreased length of long bones J:52369
decreased mature B cell number J:52369
decreased osteoclast cell number J:52369
decreased thymus weight J:52369
extramedullary hematopoiesis J:52369
failure of tooth eruption J:52369, J:64718
normal hematopoietic system phenotype J:52369
normal homeostasis/metabolism phenotype J:52369
normal immune system phenotype J:52369
increased bone mineral density J:52369
increased diameter of long bones J:52369
increased spleen weight J:52369
lactation failure J:64718
macrocytic anemia J:52369
osteopetrosis J:52369, J:64718
postnatal growth retardation J:52369
round face J:52369
small Peyer's patches J:52369
thin neurocranium J:52369
thymus hypoplasia J:52369
Tnfsf11tm1Ywc/Tnfsf11+
involves: 129P2/OlaHsd 		absent peripheral lymph nodes J:65888
Tnfsf11tm1Ywc/Tnfsf11tm1Ywc
involves: 129P2/OlaHsd 		abnormal bone marrow morphology J:233265
abnormal cervical lymph node morphology J:65888
abnormal chondrocyte differentiation J:64737
abnormal chondrocyte morphology J:64737
abnormal long bone epiphyseal plate morphology J:64737
abnormal long bone epiphyseal plate proliferative zone J:64737
abnormal long bone internal diameter J:233265
abnormal lung morphology J:233265
abnormal pelvic girdle bone morphology J:64737
abnormal spleen B cell follicle morphology J:65888
abnormal spleen marginal zone morphology J:65888
abnormal spleen morphology J:65888
abnormal splenic cell ratio J:233265
abnormal thymus cell ratio J:233265
absent cervical lymph nodes J:65888
absent mesenteric lymph nodes J:65888
absent peripheral lymph nodes J:65888
decreased body weight J:233265
decreased bone marrow cell number J:233265
decreased bone mineral density J:233265
decreased bone trabecula number J:233265
decreased circulating calcium level J:233265
decreased cranium height J:64737
decreased Langerhans cell number J:137471
decreased length of long bones J:64737
decreased osteoclast cell number J:64737, J:65888
decreased Peyer's patch number J:233265
decreased spleen white pulp amount J:233265
extramedullary hematopoiesis J:233265
failure of tooth eruption J:64737, J:233265
increased bone mineral density J:233265
increased bone mineralization J:233265
increased bone volume J:233265
increased diameter of tibia J:64737
increased long bone epiphyseal plate size J:64737
increased spleen red pulp amount J:233265
increased trabecular bone thickness J:233265
increased width of hypertrophic chondrocyte zone J:64737
optic canal stenosis J:233265
osteopetrosis J:233265
short tibia J:64737
short vertebral column J:64737
small Peyer's patches J:233265
small thymus medulla J:233265
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory