Tnfsf11 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tnfsf11
tumor necrosis factor (ligand) superfamily, member 11
MGI:1100089

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cd40^tm1Kik/Cd40^tm1Kik Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr involves: 129P2/OlaHsd	abnormal thymus epithelium morphology	J:173115
Ltbr^tm1Mmat/Ltbr^tm1Mmat Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal thymus epithelium morphology	J:173115
Tg(Bglap2-TAg)1Rkho/0 Tnfsf11^tm1Pngr/Tnfsf11⁺ involves: 129P2/OlaHsd * FVB/N	increased osteosarcoma incidence	J:234128
Tg(Bglap2-TAg)1Rkho/0 Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr involves: 129P2/OlaHsd * FVB/N	abnormal femur morphology	J:234128
	decreased osteosarcoma incidence	J:234128
Tg(TNFSF11)5516Edou/0 Tnfsf11^tles/Tnfsf11^tles involves: 129S6/SvEvTac * C57BL/6J * CBA/J	abnormal tooth eruption	J:233240
	absent lymph nodes	J:233240
	normal mortality/aging	J:233240
	normal skeleton phenotype	J:233240
Tg(TNFSF11)5519Edou/0 Tnfsf11^tles/Tnfsf11^tles involves: 129S6/SvEvTac * C57BL/6J * CBA/J	no abnormal phenotype detected	J:233240
Tnfsf11^{tm1(TNFSF11)Kost}/Tnfsf11^{tm1(TNFSF11)Kost} involves: 129/Sv * Black Swiss	abnormal bone mineralization	J:166279
	abnormal bone remodeling	J:166279
	abnormal bone structure	J:166279
	abnormal osteoblast morphology	J:166279
	abnormal osteoclast morphology	J:166279
	abnormal skeleton physiology	J:166279
	decreased body weight	J:166279
	increased bone mineral density	J:166279
	increased bone trabecula number	J:166279
	increased bone volume	J:166279
	increased femoral compact bone area	J:166279
	increased trabecular bone thickness	J:166279
	increased trabecular bone volume	J:166279

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24