Ercc6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ercc6
excision repair cross-complementing rodent repair deficiency, complementation group 6
MGI:1100494

23 phenotypes from 1 allele in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ercc6^tm1Gvh/Ercc6^tm1Gvh B6J.129P2-Ercc6^tm1Gvh	cochlear inner hair cell degeneration	J:219993
	cochlear outer hair cell degeneration	J:219993
	decreased distortion product otoacoustic emission amplitude	J:219993
	degeneration of organ of Corti supporting cells	J:219993
	Deiters cell degeneration	J:219993
	impaired hearing	J:219993
	increased or absent threshold for auditory brainstem response	J:219993
	pillar cell degeneration	J:219993
Ercc6^tm1Gvh/Ercc6^tm1Gvh involves: 129P2/OlaHsd * C57BL/6J	astrocytosis	J:179808
	increased cellular sensitivity to ultraviolet irradiation	J:122013
	microgliosis	J:179808
	postnatal growth retardation	J:122013
	retina degeneration	J:122013
Ercc6^tm1Gvh/Ercc6^tm1Gvh involves: 129P2/OlaHsd * CBA/CaJ	impaired hearing	J:219993
Ercc6^tm1Gvh/Ercc6^tm1Gvh involves: 129P2/OlaHsd * CBA/CaJ	increased or absent threshold for auditory brainstem response	J:219993
Ercc6^tm1Gvh/Ercc6^tm1Gvh involves: 129P2/OlaHsd * FVB	abnormal cell physiology	J:40211
	abnormal locomotor behavior	J:40211
	circling	J:40211
	decreased body weight	J:40211
	impaired balance	J:40211
	impaired coordination	J:40211
	increased cellular sensitivity to ultraviolet irradiation	J:40211
	increased incidence of induced tumors	J:40211
	photophobia	J:40211
	photosensitivity	J:40211
	skin photosensitivity	J:40211

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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