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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pitx3
paired-like homeodomain transcription factor 3
MGI:1100498
82 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pitx3ak/Pitx3ak
either: (involves: 129/Sv * C57BLKS) or (involves: 129/Sv * C57BL/6) 		abnormal anterior eye segment morphology J:5084
abnormal eye distance/ position J:5084
abnormal iris pigmentation J:5084
abnormal lens development J:5084
abnormal midbrain morphology J:82746, J:82907
abnormal ocular fundus morphology J:5084
abnormal posterior eye segment morphology J:5084
abnormal retina morphology J:5084
acoria J:5084
decreased body size J:5084
decreased locomotor activity J:82907
decreased substantia nigra size J:82746
enlarged lacrimal gland J:5084
microphthalmia J:5084
reduced fertility J:5084
retina fold J:5084
Pitx3ak/Pitx3ak
involves: 129S1/Sv * C57BL/6 * C57BLKS/J 		abnormal dorsal striatum morphology J:109319
abnormal locomotor behavior J:98209
abnormal substantia nigra pars compacta morphology J:109319
decreased dopamine level J:109319
decreased vertical activity J:98209
impaired coordination J:98209
increased locomotor activity J:98209
loss of dopaminergic neurons J:109319
Pitx3eyl/Pitx3eyl
involves: C3H/He * C57BL/6 		abnormal food intake J:156878
abnormal immunoglobulin level J:156878
abnormal respiration J:156878
abnormal respiratory function J:156878
abnormal retina morphology J:156878
aphakia J:156878
decreased anxiety-related response J:156878
decreased blood uric acid level J:156878
decreased body length J:156878
decreased body weight J:156878
decreased bone mass J:156878
decreased chemical nociceptive threshold J:156878
decreased circulating amylase level J:156878
decreased circulating cholesterol level J:156878
decreased circulating iron level J:156878
decreased circulating triglyceride level J:156878
decreased dopaminergic neuron number J:156878
decreased exploration in new environment J:156878
decreased grip strength J:156878
decreased IgG3 level J:156878
decreased IgM level J:156878
decreased leukocyte cell number J:156878
decreased thermal nociceptive threshold J:156878
decreased tidal volume J:156878
decreased total body fat amount J:156878
disorganized retina layers J:156878
eyelids fail to open J:156878
fused cornea and lens J:156878
hepatic steatosis J:156878
hyperresponsive to tactile stimuli J:156878
increased anxiety-related response J:156878
increased blood uric acid level J:156878
increased body temperature J:156878
increased CD4-positive, alpha-beta T cell number J:156878
increased CD8-positive, alpha-beta T cell number J:156878
increased circulating alkaline phosphatase level J:156878
increased circulating phosphate level J:156878
increased cornea thickness J:156878
increased energy expenditure J:156878
increased granulocyte number J:156878
increased lean body mass J:156878
increased pulmonary respiratory rate J:156878
microphthalmia J:156878
retina fold J:156878
thrombocytopenia J:156878
Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J 		abnormal motor coordination/balance J:211773
abnormal motor learning J:211773
abnormal sleep behavior J:211773
anophthalmia J:211773
decreased circulating free fatty acids level J:211773
decreased circulating glucose level J:211773
decreased vertical activity J:211773
hyperactivity J:211773
increased coping response J:211773
increased fasting circulating glucose level J:211773
increased grip strength J:211773
increased heart rate J:211773
shortened ST segment J:211773
Pitx3tm1.1Jdr/Pitx3tm1.1Jdr
involves: 129 * 129X1/SvJ * C57BL/6 		abnormal eye morphology J:122955
loss of dopaminergic neurons J:122955
Pitx3tm1Mli/Pitx3tm1Mli
involves: 129P2/OlaHsd 		increased neuron apoptosis J:99395
increased neuron number J:99395
loss of dopaminergic neurons J:99395
Pitx3tm2Mli/Pitx3tm2Mli
Not Specified 		normal nervous system phenotype J:133341
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory