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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pitx3
paired-like homeodomain transcription factor 3
MGI:1100498
17 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pitx3tm1.1Cai/Pitx3+
Tg(tetO-SNCA*A53T)E2Cai/0
involves: 129 * C57BL/6J * FVB/N 		abnormal autophagy J:185958
abnormal dopaminergic neuron morphology J:185958
abnormal gait J:185958
abnormal neurite morphology J:185958
abnormal neuron physiology J:185958
abnormal synaptic dopamine release J:185958
alpha-synuclein inclusion body J:185958
astrocytosis J:185958
decreased dopamine level J:185958
decreased locomotor activity J:185958
decreased vertical activity J:185958
impaired coordination J:185958
loss of dopaminergic neurons J:185958
microgliosis J:185958
neuron degeneration J:185958
short stride length J:185958
slow postnatal weight gain J:185958
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory