Kcnj8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Kcnj8
potassium inwardly-rectifying channel, subfamily J, member 8
MGI:1100508

27 phenotypes from 6 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Kcnj8^em1Nich/Kcnj8⁺ involves: C57BL/6J * CBA/J	abnormal aorta morphology	J:281903
	abnormal channel response	J:281903
	abnormal heart echocardiography feature	J:281903
	abnormal heart left ventricle morphology	J:281903
	abnormal vascular smooth muscle physiology	J:281903
	aortic arch dilation	J:281903
	aortic valve regurgitation	J:281903
	aortic valve stenosis	J:281903
	cardiac hypertrophy	J:281903
	decreased survivor rate	J:281903
	dilated heart left ventricle	J:281903
	enlarged heart	J:281903
	hypotension	J:281903
	increased cardiac output	J:281903
	increased heart weight	J:281903
	increased myocardial fiber size	J:281903
	increased vasodilation	J:281903
	premature death	J:281903
Kcnj8^em1Nich/Kcnj8^em1Nich involves: C57BL/6J * CBA/J	abnormal intestine morphology	J:281903
	premature death	J:281903
	weight loss	J:281903
Kcnj8^sos/Kcnj8^sos C57BL/6J-Kcnj8^sos	increased susceptibility to endotoxin shock	J:149353
Kcnj8^tm1Sse/Kcnj8^tm1Sse involves: 129S1/Sv * 129X1/SvJ	abnormal vascular smooth muscle physiology	J:202037
Kcnj8^tm1Sse/Kcnj8^tm1Sse involves: 129S1/Sv * 129X1/SvJ	hypertension	J:202037
Kcnj8^tm1Sse/Kcnj8^tm1Sse involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal myocardial fiber physiology	J:76195
	normal cardiovascular system phenotype	J:76195
	coronary artery spasm	J:76195
	irregular heartbeat	J:76195
	premature death	J:76195
Tg(ACTB-EGFP,-Kcnj8)1Nich/0 Tg(Myh11-icre/ERT2)1Soff/0 involves: C57BL/6 * CBA * FVB/N	normal cardiovascular system phenotype	J:202037
Tg(ACTB-EGFP,-Kcnj8G343D)9Nich/0 Tg(Myh11-icre/ERT2)1Soff/0 involves: C57BL/6 CBA * FVB/N	abnormal vascular smooth muscle physiology	J:202037
	decreased vasoconstriction	J:202037
	hypotension	J:202037
Tg(ACTB-EGFP,-Kcnj8Q53RG343D)1Nich/0 Tg(Myh11-icre/ERT2)1Soff/0 involves: C57BL/6 * CBA * FVB/N	hypotension	J:202037

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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