Bub1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bub1
BUB1, mitotic checkpoint serine/threonine kinase
MGI:1100510

48 phenotypes from 10 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Bub1^em1(IMPC)Bay/Bub1^em1(IMPC)Bay C57BL/6N-Bub1^em1(IMPC)Bay/Bay	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Bub1^Gt(XG453)Byg/Bub1⁺ involves: 129P2/OlaHsd * C57BL/6J	maternal effect	J:143035
Bub1^Gt(XG453)Byg/Bub1^tm1.1Tvd involves: 129P2/OlaHsd * C57BL/6J	embryonic lethality during organogenesis, complete penetrance	J:143035
Bub1^tm1.1Jvd/Bub1⁺ involves: 129/Sv * C57BL/6	abnormal cell cycle checkpoint function	J:135093
	abnormal mitosis	J:135093
	aneuploidy	J:135093
	decreased fibroblast apoptosis	J:135093
	decreased tumor incidence	J:135093
	increased incidence of tumors by chemical induction	J:135093
Bub1^tm1.1Jvd/Bub1^tm1.1Jvd involves: 129/Sv * C57BL/6	embryonic lethality between implantation and somite formation, complete penetrance	J:135093
Bub1^tm1.1Jvd/Bub1^tm2Jvd involves: 129/Sv * C57BL/6	abnormal cell cycle checkpoint function	J:135093
	abnormal mitosis	J:135093
	aneuploidy	J:135093
	decreased fibroblast apoptosis	J:135093
	decreased tumor latency	J:135093
	increased lung tumor incidence	J:135093
	increased lymphoma incidence	J:135093
	increased sarcoma incidence	J:135093
Bub1^tm1.1Ssta/Bub1^tm1.1Ssta involves: 129S1/Sv * 129X1/SvJ * C57BL/6	embryonic lethality, complete penetrance	J:128455
Bub1^tm1.1Tvd/Bub1⁺ involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	aneuploidy	J:143035
	increased brain tumor incidence	J:143035
	increased lung tumor incidence	J:143035
Bub1^tm1.1Tvd/Bub1^tm1.1Tvd B6.129P2-Bub1^tm1.1Tvd	anemia	J:143035
	decreased birth weight	J:143035
	hepatic necrosis	J:143035
	increased leukocyte cell number	J:143035
	pale liver	J:143035
	perinatal lethality, incomplete penetrance	J:143035
Bub1^tm1.1Tvd/Bub1^tm1.1Tvd FVB.129P2-Bub1^tm1.1Tvd	normal mortality/aging	J:143035
Bub1^tm1.1Tvd/Bub1^tm1.1Tvd involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	abnormal cell cycle	J:143035
	abnormal cell cycle checkpoint function	J:143035
	abnormal mitotic spindle assembly checkpoint	J:143035
	abnormal mitotic spindle morphology	J:143035
	aneuploidy	J:143035
	decreased fibroblast proliferation	J:143035
	early cellular replicative senescence	J:143035
	increased incidence of induced tumors	J:143035
	increased liver tumor incidence	J:143035
	increased lung tumor incidence	J:143035
	perinatal lethality, incomplete penetrance	J:143035
Bub1^tm1Ssta/Bub1^tm1.1Ssta Tg(CAG-cre/Esr1)5Amc/? involves: 129S1/Sv 129X1/SvJ * C57BL/6 * CBA	abnormal cell cycle	J:128455
	abnormal mitotic spindle assembly checkpoint	J:128455
	decreased cell proliferation	J:128455
Bub1^tm1Ssta/Bub1^tm1Ssta Tg(CAG-cre/Esr1)5Amc/? involves: 129S1/Sv 129X1/SvJ * C57BL/6 * CBA	abnormal spermatogenesis	J:128455
	decreased fetal size	J:128455
	decreased mitotic index	J:128455
	decreased testis weight	J:128455
	fetal growth retardation	J:128455
	male infertility	J:128455
	oligozoospermia	J:128455
	small seminiferous tubules	J:128455
Bub1^tm1Tvd/Bub1⁺ involves: 129P2/OlaHsd * C57BL/6J	no abnormal phenotype detected	J:143035
Bub1^tm2Jvd/Bub1⁺ involves: 129/Sv * C57BL/6	abnormal cell cycle checkpoint function	J:135093
	abnormal mitosis	J:135093
	aneuploidy	J:135093
	decreased fibroblast apoptosis	J:135093
Bub1^tm2Jvd/Bub1^tm2Jvd involves: 129/Sv * C57BL/6	abnormal cell cycle checkpoint function	J:135093
	abnormal mitosis	J:135093
	aneuploidy	J:135093
	decreased fibroblast apoptosis	J:135093
	decreased tumor latency	J:135093
	increased hepatocellular carcinoma incidence	J:135093
	increased sarcoma incidence	J:135093
Bub1^tm3.1Jvd/Bub1^tm3.1Jvd involves: 129S4/SvJae * C57BL/6	abnormal cell cycle checkpoint function	J:195237
	aneuploidy	J:195237
	chromosomal instability	J:195237
	decreased litter size	J:195237
	decreased testis weight	J:195237
	normal neoplasm	J:195237
	oligozoospermia	J:195237
	reduced male fertility	J:195237
	small seminiferous tubules	J:195237
	small testis	J:195237
Bub1^tm4.1Jvd/Bub1^tm4.1Jvd involves: 129S4/SvJaeSor	abnormal cell death	J:195237

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