Lmx1b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lmx1b
LIM homeobox transcription factor 1 beta
MGI:1100513

115 phenotypes from 8 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm1(CAG-Lmx1b,ALPP)Rjo}/Gt(ROSA)26Sor⁺ Tg(Prrx1-cre)1Cjt/0 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J	abnormal ankle joint morphology	J:158676
	abnormal foot pad morphology	J:158676
	abnormal skeleton morphology	J:158676
	abnormal tendon morphology	J:158676
	decreased skeletal muscle mass	J:158676
Gt(ROSA)26Sor^{tm1(CAG-Lmx1b,ALPP)Rjo}/Gt(ROSA)26Sor⁺ Sox9^tm3(cre)Crm/Sox9⁺ involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	abnormal ankle joint morphology	J:158676
	abnormal foot pad morphology	J:158676
	abnormal skeleton morphology	J:158676
	abnormal tendon morphology	J:158676
	decreased skeletal muscle mass	J:158676
Lmx1b^Icst/Lmx1b⁺ involves: BALB/cAnN * C3H/HeN	abnormal cornea endothelium morphology	J:75964, J:215517
	abnormal Descemet membrane morphology	J:215517
	abnormal eye morphology	J:75964
	abnormal iridocorneal angle	J:215517
	abnormal iris morphology	J:75964, J:215517
	abnormal optic nerve morphology	J:215517
	abnormal renal glomerulus morphology	J:215517
	anterior iris synechia	J:75964, J:215517
	buphthalmos	J:215517
	cornea opacity	J:75964, J:215517
	cornea scarring	J:75964, J:215517
	cornea ulcer	J:215517
	cornea vascularization	J:215517
	irregularly shaped pupil	J:75964
	macrophthalmia	J:75964
	ocular hypertension	J:215517
	perinatal lethality, incomplete penetrance	J:215517
Lmx1b^Icst/Lmx1b^Icst involves: BALB/cAnN * C3H/HeN	abnormal kidney morphology	J:215517
	abnormal limb position	J:215517
	abnormal podocyte morphology	J:215517
	absent cerebellum	J:215517
	perinatal lethality, complete penetrance	J:215517
Lmx1b^tm1Bbs/? involves: 129 * C57BL/6	no abnormal phenotype detected	J:89459
Lmx1b^tm1Rjo/Lmx1b^tm1Rjo involves: 129 * C57BL/6	abnormal anterior eye segment morphology	J:60307
	abnormal cartilage development	J:48536
	abnormal ciliary body morphology	J:60307
	abnormal clavicle morphology	J:47316
	abnormal cornea stroma morphology	J:60307
	abnormal cranial suture morphology	J:48536
	abnormal developmental patterning	J:47316
	abnormal fontanelle morphology	J:48536
	abnormal interparietal bone morphology	J:48536
	abnormal iris stroma morphology	J:60307
	abnormal lens epithelium morphology	J:60307
	abnormal pectoral girdle bone morphology	J:47316
	abnormal renal glomerulus basement membrane morphology	J:47316
	abnormal suckling behavior	J:47316
	absence of all nails	J:47316
	absent ilium	J:47316
	absent patella	J:47316
	absent supraoccipital bone	J:48536
	absent ulna	J:47316
	decreased eye anterior chamber depth	J:60307
	increased renal glomerulus basement membrane thickness	J:47316
	irregularly shaped pupil	J:60307
	microphthalmia	J:60307
	neonatal lethality, complete penetrance	J:47316
	small scapula	J:47316
Lmx1b^tm1Rjo/Lmx1b^tm1Rjo involves: 129S7/SvEvBrd	abnormal brain development	J:117035
	abnormal cerebellum morphology	J:117035
	abnormal cerebral cortex morphology	J:117035
	abnormal cornea morphology	J:161793
	abnormal cornea stroma morphology	J:161793
	abnormal lens epithelium morphology	J:161793
	abnormal midbrain-hindbrain boundary development	J:117035
	abnormal pretectal region morphology	J:117035
	abnormal sensory neuron innervation pattern	J:95961
	abnormal superior colliculus morphology	J:117035
	abnormal tectum morphology	J:117035
	absent midbrain-hindbrain boundary	J:117035
	ciliary body hypoplasia	J:161793
	cornea vascularization	J:161793
	decreased eye anterior chamber depth	J:161793
	decreased rhombomere 1 size	J:117035
	decreased superior colliculus size	J:117035
	iris stroma hypoplasia	J:161793
	irregularly shaped pupil	J:161793
	microphthalmia	J:161793
	small cerebellum	J:117035
	small tectum	J:117035
Lmx1b^tm1Rjo/Lmx1b^tm1Rjo involves: 129S7/SvEvBrd * C57BL/6	abnormal neuron morphology	J:95961
Lmx1b^tm1Rjo/Lmx1b^tm1Rjo involves: 129S7/SvEvBrd * C57BL/6J	abnormal dopaminergic neuron morphology	J:175535
	decreased motor neuron number	J:175535
	decreased neuronal precursor cell number	J:175535
	increased neuron number	J:175535
Lmx1b^tm1Rjo/Lmx1b^tm1Rjo involves: C57BL/6	abnormal glomerular capillary endothelium morphology	J:76088
	abnormal glomerular capillary morphology	J:76088
	abnormal podocyte morphology	J:76088
	abnormal renal glomerulus basement membrane morphology	J:76088
	abnormal renal glomerulus morphology	J:76088
	absent glomerular endothelium fenestra	J:76088
	absent podocyte foot process	J:76088
	absent podocyte slit diaphragm	J:76088
	small kidney	J:76088
Lmx1b^tm1Rjo/Lmx1b^tm1Rjo Not Specified	abnormal podocyte foot process morphology	J:76089
	abnormal podocyte morphology	J:76089
	absent podocyte slit diaphragm	J:76089
Lmx1b^tm1Rjo/Lmx1b^tm1Zfc H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129S7/SvEvBrd * C57BL/6 * CBA	small cerebellum	J:117035
	small tectum	J:117035
Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Sox9^tm3(cre)Crm/Sox9⁺ involves: 129S7/SvEvBrd	abnormal metacarpal bone morphology	J:158676
	normal skeleton phenotype	J:158676
Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Tg(Lmx1a-cre)1Kjmi/0 involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6	normal nervous system phenotype	J:152673
Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Tg(Prrx1-cre)1Cjt/0 involves: 129S7/SvEvBrd * C57BL/6J * SJL/J	abnormal foot pad morphology	J:158676
	abnormal joint morphology	J:158676
	abnormal metacarpal bone morphology	J:158676
	abnormal skeleton morphology	J:158676
	abnormal tendon morphology	J:158676
	absent patella	J:158676
Lmx1b^tm1Rjo/Lmx1b^tm4.1Rjo H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129S7/SvEvBrd * C57BL/6J * CBA/J	abnormal cornea morphology	J:161793
	abnormal cornea stroma morphology	J:161793
	abnormal lens epithelium morphology	J:161793
	ciliary body hypoplasia	J:161793
	cornea vascularization	J:161793
	decreased eye anterior chamber depth	J:161793
	iris stroma hypoplasia	J:161793
	irregularly shaped pupil	J:161793
	microphthalmia	J:161793
Lmx1b^tm1Rjo/Lmx1b^tm4.1Rjo Pitx2^tm4(cre)Jfm/Pitx2⁺ involves: 129S7/SvEvBrd	abnormal cornea endothelium morphology	J:161793
	abnormal cornea morphology	J:161793
	abnormal intraocular muscle morphology	J:161793
	abnormal iridocorneal angle	J:161793
	abnormal lens epithelium morphology	J:161793
	abnormal lens morphology	J:161793
	absent ciliary body	J:161793
	absent trabecular meshwork	J:161793
	cornea opacity	J:161793
	iris hypoplasia	J:161793
	irregularly shaped pupil	J:161793
	microphthalmia	J:161793
	small lens	J:161793
Lmx1b^tm1Rjo/Lmx1b^tm4.1Rjo Tg(CAG-cre/Esr1)5Amc/0 involves: 129S7/SvEvBrd C57BL/6 * CBA	abnormal cornea morphology	J:161793
	cornea opacity	J:161793
	cornea vascularization	J:161793
	decreased cornea epithelium thickness	J:161793
	dilated renal tubule	J:161793
	kidney degeneration	J:161793
	kidney failure	J:161793
	lethargy	J:161793
Lmx1b^tm1Zfc/Lmx1b^tm1Zfc Tg(Fev-cre)1Esd/0 involves: 129S7/SvEvBrd * C57BL/6 * SJL	abnormal contextual conditioning behavior	J:139720
	abnormal long-term depression	J:139720
	abnormal long-term potentiation	J:139720
	abnormal long-term spatial reference memory	J:139720
	abnormal mating preference	J:170988
	abnormal Raphe nucleus morphology	J:116706, J:139720
	abnormal serotonergic neuron morphology	J:116706
	normal behavior/neurological phenotype	J:116706, J:170988
	decreased anxiety-related response	J:139720
	decreased neurotransmitter release	J:139720
	decreased vocalization	J:170988
	normal nervous system phenotype	J:116706
	normal taste/olfaction phenotype	J:170988
Lmx1b^tm1Zfc/Lmx1b^tm1Zfc Tg(Fev-cre/ERT2)#Yqd/0 Not Specified	decreased serotonin level	J:168054
Lmx1b^{tm2(cre/ERT2)Rjo}/Lmx1b^{tm2(cre/ERT2)Rjo} involves: 129S4/SvJae * C57BL/6	no abnormal phenotype detected	J:149241
Lmx1b^{tm3(cre/ERT2)Rjo}/Lmx1b^{tm3(cre/ERT2)Rjo} involves: 129S4/SvJae * C57BL/6	abnormal limb development	J:149241
Lmx1b^tm4.1Rjo/Lmx1b^tm4.1Rjo Tg(NPHS2-cre)295Lbh/0 involves: 129S7/SvEvBrd * C57BL/6 * SJL	abnormal podocyte foot process morphology	J:122505
	abnormal renal glomerulus morphology	J:122505
	absent podocyte slit diaphragm	J:122505
	albuminuria	J:122505
	dilated renal tubule	J:122505
	glomerulosclerosis	J:122505
	increased renal glomerulus basement membrane thickness	J:122505
	kidney failure	J:122505
	podocyte foot process effacement	J:122505
	postnatal lethality, complete penetrance	J:122505
	renal cast	J:122505
	renal glomerular synechia	J:122505

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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