Lmx1b Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lmx1b
LIM homeobox transcription factor 1 beta
MGI:1100513

20 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Lmx1a^dr-J/Lmx1a^dr-J Lmx1b^tm1Rjo/Lmx1b^tm1Rjo involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6	abnormal fourth ventricle morphology	J:152673
Lmx1a^dr-J/Lmx1a^dr-J Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Tg(Lmx1a-cre)1Kjmi/0 involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6	abnormal cerebellum development	J:152673
	abnormal cerebellum morphology	J:152673
	abnormal fourth ventricle morphology	J:152673
	small cerebellum	J:152673
Lmx1a^tm1Ics/Lmx1a⁺ Lmx1b^tm1Rjo/Lmx1b⁺ involves: 129S7/SvEvBrd * C57BL/6J	decreased dopaminergic neuron number	J:175535
Lmx1a^tm1Ics/Lmx1a^tm1Ics Lmx1b^tm1Rjo/Lmx1b⁺ involves: 129S7/SvEvBrd * C57BL/6J	decreased dopaminergic neuron number	J:175535
Lmx1a^tm1Ics/Lmx1a^tm1Ics Lmx1b^tm1Rjo/Lmx1b^tm1Rjo involves: 129S7/SvEvBrd * C57BL/6J	embryonic lethality	J:175535
Lmx1a^tm1Tpe/Lmx1a^tm1Tpe Lmx1b^tm1Zfc/Lmx1b^tm1Zfc Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	abnormal autophagy	J:222854
	abnormal innervation	J:222854
	abnormal lysosome morphology	J:222854
	abnormal lysosome physiology	J:222854
	abnormal synapse morphology	J:222854
	abnormal synaptic bouton morphology	J:222854
	abnormal synaptic vesicle number	J:222854
	decreased dopamine level	J:222854
	enhanced long-term potentiation	J:222854
	impaired coordination	J:222854
	impaired olfaction	J:222854
	impaired short-term object recognition memory	J:222854
	increased locomotor activity	J:222854
	neurodegeneration	J:222854
Lmx1a^tm1Tpe/Lmx1a^tm1Tpe Lmx1b^tm1Zfc/Lmx1b^tm1Zfc Tg(Slc6a3-cre/ERT2)1Span/0 involves: 129S7/SvEvBrd * C57BL/6	abnormal synaptic bouton morphology	J:222854
	decreased dopamine level	J:222854
	neurodegeneration	J:222854

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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