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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nr2e1
nuclear receptor subfamily 2, group E, member 1
MGI:1100526
69 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nr2e1frc/Nr2e1frc
either: B6.129-Nr2e1frc or 129P3/JEms.Cg-Nr2e1frc or B6129F1-Nr2e1frc 		abnormal aggression-related behavior J:71869
abnormal brain commissure morphology J:71869
abnormal cerebral hemisphere morphology J:71869
abnormal eye electrophysiology J:71869
abnormal nursing J:71869
abnormal optic nerve morphology J:71869
abnormal retina ganglion layer morphology J:71869
abnormal retina inner plexiform layer morphology J:71869
abnormal retina morphology J:71869
abnormal retina nerve fiber layer morphology J:71869
abnormal retina photoreceptor layer morphology J:71869
abnormal retina vasculature morphology J:71869
abnormal sensory capabilities/reflexes/nociception J:71869
decreased body length J:71869
decreased body size J:71869
decreased body weight J:71869
decreased brain size J:71869
decreased exploration in new environment J:71869
decreased total body fat amount J:71869
enlarged brain ventricles J:71869
forebrain hypoplasia J:71869
hydrocephaly J:71869
increased aggression towards humans J:71869
increased aggression towards mice J:71869
persistence of hyaloid vascular system J:71869
reduced female fertility J:71869
slow postnatal weight gain J:71869
thin retina inner nuclear layer J:71869
Nr2e1frc/Nr2e1frc
involves: 129P2/OlaHsd * 129S1/SvImJ 		abnormal cerebral hemisphere morphology J:183689
abnormal eye electrophysiology J:183689
abnormal neuronal precursor proliferation J:183689
abnormal retina ganglion cell morphology J:183689
abnormal retina vasculature morphology J:183689
small olfactory bulb J:183689
thin retina inner nuclear layer J:183689
thin retina outer nuclear layer J:183689
Nr2e1tm1Gsc/Nr2e1tm1Gsc
involves: 129 * C57BL/6 		abnormal amygdala morphology J:44679
abnormal cortical intermediate zone morphology J:44679
abnormal dentate gyrus morphology J:44679
abnormal entorhinal cortex morphology J:44679
abnormal hippocampal mossy fiber morphology J:44679
abnormal learning/memory/conditioning J:44679
abnormal limbic system morphology J:44679
abnormal maternal nurturing J:44679
abnormal olfactory cortex morphology J:44679
decreased anterior commissure size J:44679
decreased brain size J:44679
decreased subiculum size J:44679
increased aggression J:44679
slow postnatal weight gain J:44679
small olfactory bulb J:44679
Nr2e1tm1Rev/Nr2e1tm1Rev
Tg(CAG-cre/Esr1*)5Amc/?
involves: C57BL/6 * CBA 		abnormal neuron differentiation J:132664
normal behavior/neurological phenotype J:132664
Nr2e1tm1Rev/Nr2e1tm1Rev
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal dentate gyrus morphology J:132664
abnormal short-term spatial reference memory J:132664
abnormal spatial learning J:132664
normal behavior/neurological phenotype J:132664
normal vision/eye phenotype J:132664
Nr2e1tm1Rev/Nr2e1tm1Rtyu
Not Specified 		abnormal neuron differentiation J:132664
Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Not Specified 		abnormal amygdala morphology J:81762
abnormal axon fasciculation J:81762
abnormal eye electrophysiology J:61179
abnormal lateral ganglionic eminence morphology J:81762
abnormal optic nerve morphology J:61179
abnormal optic stalk morphology J:61179
abnormal pallium development J:81762
abnormal retina ganglion layer morphology J:61179
abnormal retina inner nuclear layer morphology J:61179
abnormal retina morphology J:61179
abnormal retina outer nuclear layer morphology J:61179
abnormal retina outer plexiform layer morphology J:61179
abnormal telencephalon development J:81762
absent photoreceptor outer segment J:61179
blindness J:61179
decreased radial glial cell number J:81762
disorganized retina ganglion layer J:61179
disorganized retina inner nuclear layer J:61179
disorganized retina outer nuclear layer J:61179
increased susceptibility to age-related retinal degeneration J:61179
optic nerve degeneration J:61179
Nr2e1tm2Gsc/Nr2e1tm2Gsc
Tg(Camk2a-cre)2Gsc/?
involves: C57BL/6 * FVB/N * SJL 		normal behavior/neurological phenotype J:127237
decreased anxiety-related response J:127237
decreased brain size J:127237
dilated lateral ventricle J:127237
increased aggression towards mice J:127237
postnatal growth retardation J:127237
small hippocampus J:127237
normal vision/eye phenotype J:127237
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory