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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Med1
mediator complex subunit 1
MGI:1100846
89 phenotypes from 7 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Med1tm1.1Mpk/Med1tm1.1Mpk
involves: 129P2/OlaHsd * C57BL/6J 		abnormal eye development J:86857
abnormal heart morphology J:86857
abnormal limb morphology J:86857
absent megakaryocytes J:86857
embryonic lethality during organogenesis, complete penetrance J:86857
impaired placental function J:86857
increased nucleated erythrocyte cell number J:86857
thin ventricular wall J:86857
trabecula carnea hypoplasia J:86857
ventricular hypoplasia J:86857
Med1tm1Jkr/Med1tm1Jkr
involves: 129P2/OlaHsd * C57BL/6 		abnormal cardiovascular development J:74328
abnormal cardiovascular system morphology J:74328
abnormal cardiovascular system physiology J:62272, J:74328
abnormal definitive hematopoiesis J:74328
abnormal extraembryonic tissue morphology J:62272
abnormal lens development J:74328
abnormal lens epithelium morphology J:74328
abnormal placenta labyrinth morphology J:62272
abnormal placenta vasculature J:62272, J:74328
abnormal placental labyrinth vasculature morphology J:62272
abnormal retina pigmentation J:74328
abnormal spongiotrophoblast layer morphology J:62272
abnormal trophoblast giant cell morphology J:62272
abnormal vascular endothelial cell development J:74328
absent megakaryocytes J:74328
decreased embryo size J:62272
dilated liver sinusoidal space J:74328
embryonic growth retardation J:62272
embryonic lethality during organogenesis, complete penetrance J:62272
increased angiogenesis J:74328
increased vascular permeability J:74328
myocardial trabeculae hypoplasia J:74328
myocardium hypoplasia J:74328
pericardial effusion J:74328
thin myocardium J:62272
thin ventricular wall J:74328
trabecula carnea hypoplasia J:74328
ventricular hypoplasia J:74328
Med1tm1Mpk/Med1tm1Mpk
involves: 129P2/OlaHsd * C57BL/6J 		abnormal eye development J:86857
abnormal heart morphology J:86857
abnormal limb morphology J:86857
embryonic growth retardation J:86857
embryonic lethality during organogenesis, complete penetrance J:86857
increased nucleated erythrocyte cell number J:86857
thin ventricular wall J:86857
trabecula carnea hypoplasia J:86857
Med1tm1Rgr/Med1+
either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6J) 		abnormal metabolism J:61840
decreased activity of thyroid gland J:61840
decreased body height J:61840
decreased body size J:61840
decreased circulating thyroxine level J:61840
decreased circulating triiodothyronine level J:61840
decreased thyroid-stimulating hormone level J:61840
postnatal growth retardation J:61840
Med1tm1Rgr/Med1tm1Rgr
either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * 129X1/SvJ) 		abnormal blood vessel morphology J:61840
abnormal brain morphology J:61840
abnormal bronchus morphology J:61840
abnormal cardiovascular system morphology J:61840
abnormal cardiovascular system physiology J:61840
abnormal cell cycle J:61840
abnormal embryonic neuroepithelium morphology J:61840
abnormal forebrain development J:61840
abnormal liver development J:61840
abnormal myocardial trabeculae morphology J:61840
abnormal nervous system morphology J:61840
abnormal neuron apoptosis J:61840
abnormal telencephalon development J:61840
abnormal vena cava morphology J:61840
decreased embryo size J:61840
decreased fibroblast proliferation J:61840
embryonic lethality between somite formation and embryo turning, incomplete penetrance J:61840
embryonic lethality, complete penetrance J:61840
enlarged heart J:61840
heart hypoplasia J:61840
microcephaly J:61840
postnatal growth retardation J:61840
thin myocardium compact layer J:61840
thin ventricular wall J:61840
trabecula carnea hypoplasia J:61840
Med1tm2Jkr/Med1tm2Jkr
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129P2/OlaHsd * FVB/N 		abnormal heart echocardiography feature J:243730
abnormal heart morphology J:243730
cardiac interstitial fibrosis J:243730
congestive heart failure J:243730
decreased cardiac muscle contractility J:243730
dilated cardiomyopathy J:243730
dilated heart ventricle J:243730
enlarged heart J:243730
increased cardiomyocyte apoptosis J:243730
premature death J:243730
thin ventricular wall J:243730
Med1tm2Jkr/Med1tm2Jkr
Tg(Alb1-cre)1Dlr/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal hepatocyte morphology J:94123
Med1tm2Jkr/Med1tm2Jkr
Tg(Myh6-cre)2182Mds/0
involves: 129P2/OlaHsd * FVB/N 		abnormal heart echocardiography feature J:243730
abnormal myocardial fiber morphology J:243730
abnormal Z line morphology J:243730
cardiac edema J:243730
cardiac interstitial fibrosis J:243730
congestive heart failure J:243730
decreased cardiac muscle contractility J:243730
decreased myocardial fiber mitochondrial DNA content J:243730
dilated cardiomyopathy J:243730
dilated heart atrium J:243730
dilated heart ventricle J:243730
enlarged heart J:243730
increased cardiomyocyte apoptosis J:243730
premature death J:243730
pulmonary edema J:243730
thin ventricular wall J:243730
Med1tm2Rgr/Med1tm2Rgr
B6.129P2-Med1tm2Rgr 		abnormal branching of the mammary ductal tree J:159303
abnormal mammary gland development J:159303
abnormal mammary gland epithelium morphology J:159303
decreased mammary gland epithelial cell proliferation J:159303
Med1tm3b(EUCOMM)Wtsi/Med1+
C57BL/6N-Med1tm3b(EUCOMM)Wtsi/Tcp 		abnormal eye morphology J:211773
enlarged uterus J:211773
hydrometra J:211773
small superior vagus ganglion J:211773
Med1tm3b(EUCOMM)Wtsi/Med1tm3b(EUCOMM)Wtsi
C57BL/6N-Med1tm3b(EUCOMM)Wtsi/Tcp 		abnormal embryo size J:211773
abnormal eye morphology J:211773
abnormal placenta size J:211773
embryonic lethality prior to tooth bud stage J:211773
pale yolk sac J:211773
pallor J:211773
preweaning lethality, complete penetrance J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory