About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Med1
mediator complex subunit 1
MGI:1100846
89 phenotypes from 7 alleles in 7 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Med1tm1.1Mpk/Med1tm1.1Mpk
involves: 129P2/OlaHsd * C57BL/6J 		abnormal eye development J:86857
abnormal heart morphology J:86857
abnormal limb morphology J:86857
absent megakaryocytes J:86857
embryonic lethality during organogenesis, complete penetrance J:86857
impaired placental function J:86857
increased nucleated erythrocyte cell number J:86857
thin ventricular wall J:86857
trabecula carnea hypoplasia J:86857
ventricular hypoplasia J:86857
Med1tm1Jkr/Med1tm1Jkr
involves: 129P2/OlaHsd * C57BL/6 		abnormal cardiovascular development J:74328
abnormal cardiovascular system morphology J:74328
abnormal cardiovascular system physiology J:62272, J:74328
abnormal definitive hematopoiesis J:74328
abnormal extraembryonic tissue morphology J:62272
abnormal lens development J:74328
abnormal lens epithelium morphology J:74328
abnormal placenta labyrinth morphology J:62272
abnormal placenta vasculature J:62272, J:74328
abnormal placental labyrinth vasculature morphology J:62272
abnormal retina pigmentation J:74328
abnormal spongiotrophoblast layer morphology J:62272
abnormal trophoblast giant cell morphology J:62272
abnormal vascular endothelial cell development J:74328
absent megakaryocytes J:74328
decreased embryo size J:62272
dilated liver sinusoidal space J:74328
embryonic growth retardation J:62272
embryonic lethality during organogenesis, complete penetrance J:62272
increased angiogenesis J:74328
increased vascular permeability J:74328
myocardial trabeculae hypoplasia J:74328
myocardium hypoplasia J:74328
pericardial effusion J:74328
thin myocardium J:62272
thin ventricular wall J:74328
trabecula carnea hypoplasia J:74328
ventricular hypoplasia J:74328
Med1tm1Mpk/Med1tm1Mpk
involves: 129P2/OlaHsd * C57BL/6J 		abnormal eye development J:86857
abnormal heart morphology J:86857
abnormal limb morphology J:86857
embryonic growth retardation J:86857
embryonic lethality during organogenesis, complete penetrance J:86857
increased nucleated erythrocyte cell number J:86857
thin ventricular wall J:86857
trabecula carnea hypoplasia J:86857
Med1tm1Rgr/Med1+
either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6J) 		abnormal metabolism J:61840
decreased activity of thyroid gland J:61840
decreased body height J:61840
decreased body size J:61840
decreased circulating thyroxine level J:61840
decreased circulating triiodothyronine level J:61840
decreased thyroid-stimulating hormone level J:61840
postnatal growth retardation J:61840
Med1tm1Rgr/Med1tm1Rgr
either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * 129X1/SvJ) 		abnormal blood vessel morphology J:61840
abnormal brain morphology J:61840
abnormal bronchus morphology J:61840
abnormal cardiovascular system morphology J:61840
abnormal cardiovascular system physiology J:61840
abnormal cell cycle J:61840
abnormal embryonic neuroepithelium morphology J:61840
abnormal forebrain development J:61840
abnormal liver development J:61840
abnormal myocardial trabeculae morphology J:61840
abnormal nervous system morphology J:61840
abnormal neuron apoptosis J:61840
abnormal telencephalon development J:61840
abnormal vena cava morphology J:61840
decreased embryo size J:61840
decreased fibroblast proliferation J:61840
embryonic lethality between somite formation and embryo turning, incomplete penetrance J:61840
embryonic lethality, complete penetrance J:61840
enlarged heart J:61840
heart hypoplasia J:61840
microcephaly J:61840
postnatal growth retardation J:61840
thin myocardium compact layer J:61840
thin ventricular wall J:61840
trabecula carnea hypoplasia J:61840
Med1tm2Jkr/Med1tm2Jkr
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129P2/OlaHsd * FVB/N 		abnormal heart echocardiography feature J:243730
abnormal heart morphology J:243730
cardiac interstitial fibrosis J:243730
congestive heart failure J:243730
decreased cardiac muscle contractility J:243730
dilated cardiomyopathy J:243730
dilated heart ventricle J:243730
enlarged heart J:243730
increased cardiomyocyte apoptosis J:243730
premature death J:243730
thin ventricular wall J:243730
Med1tm2Jkr/Med1tm2Jkr
Tg(Alb1-cre)1Dlr/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal hepatocyte morphology J:94123
Med1tm2Jkr/Med1tm2Jkr
Tg(Myh6-cre)2182Mds/0
involves: 129P2/OlaHsd * FVB/N 		abnormal heart echocardiography feature J:243730
abnormal myocardial fiber morphology J:243730
abnormal Z line morphology J:243730
cardiac edema J:243730
cardiac interstitial fibrosis J:243730
congestive heart failure J:243730
decreased cardiac muscle contractility J:243730
decreased myocardial fiber mitochondrial DNA content J:243730
dilated cardiomyopathy J:243730
dilated heart atrium J:243730
dilated heart ventricle J:243730
enlarged heart J:243730
increased cardiomyocyte apoptosis J:243730
premature death J:243730
pulmonary edema J:243730
thin ventricular wall J:243730
Med1tm2Rgr/Med1tm2Rgr
B6.129P2-Med1tm2Rgr 		abnormal branching of the mammary ductal tree J:159303
abnormal mammary gland development J:159303
abnormal mammary gland epithelium morphology J:159303
decreased mammary gland epithelial cell proliferation J:159303
Med1tm3b(EUCOMM)Wtsi/Med1+
C57BL/6N-Med1tm3b(EUCOMM)Wtsi/Tcp 		abnormal eye morphology J:211773
enlarged uterus J:211773
hydrometra J:211773
small superior vagus ganglion J:211773
Med1tm3b(EUCOMM)Wtsi/Med1tm3b(EUCOMM)Wtsi
C57BL/6N-Med1tm3b(EUCOMM)Wtsi/Tcp 		abnormal embryo size J:211773
abnormal eye morphology J:211773
abnormal placenta size J:211773
embryonic lethality prior to tooth bud stage J:211773
pale yolk sac J:211773
pallor J:211773
preweaning lethality, complete penetrance J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory