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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Elavl1
ELAV like RNA binding protein 1
MGI:1100851
101 phenotypes from 9 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Elavl1tm1.1Atas/Elavl1tm1.1Atas
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129X1/SvJ * C57BL/6 		decreased susceptibility to experimental autoimmune encephalomyelitis J:207013
decreased T cell proliferation J:207013
decreased T-helper 17 cell number J:207013
Elavl1tm1.1Bndr/Elavl1tm1.1Bndr
Lyz2tm1(cre)Ifo/Lyz2+
B6.129-Elavl1tm1.1Bndr 		abnormal blood circulation J:182000
abnormal capillary morphology J:182000
abnormal physiological neovascularization J:182000
cellular necrosis J:182000
Elavl1tm1.1Dkon/Elavl1tm1.1Dkon
Lyz2tm1(cre)Ifo/Lyz2+
B6.129P2-Elavl1tm1.1Dkon Lyz2tm1(cre)Ifo 		abnormal macrophage chemotaxis J:184388
normal immune system phenotype J:184388
increased circulating interleukin-1 beta level J:184388
increased circulating interleukin-6 level J:184388
increased circulating interleukin-12 level J:184388
increased circulating tumor necrosis factor level J:184388
increased colon adenocarcinoma incidence J:184388
increased colon adenoma incidence J:184388
increased incidence of tumors by chemical induction J:184388
increased macrophage cell number J:184388
increased monocyte cell number J:184388
increased susceptibility to endotoxin shock J:184388
increased susceptibility to induced colitis J:184388
increased susceptibility to xenobiotic induced morbidity/mortality J:184388
increased tumor growth/size J:184388
Elavl1tm1.1Dkon/Elavl1tm1.1Dkon
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6J 		normal immune system phenotype J:184388
increased circulating interleukin-1 beta level J:184388
increased circulating interleukin-6 level J:184388
increased circulating interleukin-12 level J:184388
increased circulating tumor necrosis factor level J:184388
increased susceptibility to endotoxin shock J:184388
increased susceptibility to xenobiotic induced morbidity/mortality J:184388
Elavl1tm1.1Dkon/Elavl1tm1.1Dkon
Tg(MYOD1-cre)M23Glh/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal mitochondrial ATP synthesis coupled electron transport J:279284
abnormal muscle contractility J:279284
abnormal skeletal muscle fiber type ratio J:279284
decreased susceptibility to induced muscular atrophy J:279284
enhanced exercise endurance J:279284
increased aerobic running capacity J:279284
increased carbon dioxide production J:279284
increased oxygen consumption J:279284
increased respiratory quotient J:279284
Elavl1tm1.1Thla/Elavl1+
involves: 129S1/Sv 		decreased bone marrow cell number J:155109
increased cellular sensitivity to gamma-irradiation J:155109
spleen hypoplasia J:155109
thymus hypoplasia J:155109
Elavl1tm1.1Thla/Elavl1tm1.1Thla
involves: 129S1/Sv 		preweaning lethality, complete penetrance J:155109
Elavl1tm1.2Dkon/Elavl1tm1.2Dkon
involves: 129P2/OlaHsd * C57BL/6 		abnormal chorionic plate morphology J:149149
abnormal maternal decidual layer morphology J:149149
abnormal placental labyrinth vasculature morphology J:149149
abnormal spongiotrophoblast cell morphology J:149149
decreased spongiotrophoblast size J:149149
decreased trophoblast giant cell number J:149149
embryonic growth retardation J:149149
embryonic lethality during organogenesis, incomplete penetrance J:149149
lethality throughout fetal growth and development, complete penetrance J:149149
pale yolk sac J:149149
placental labyrinth hypoplasia J:149149
small placenta J:149149
Elavl1tm1b(EUCOMM)Hmgu/Elavl1+
C57BL/6N-Elavl1tm1b(EUCOMM)Hmgu/J 		decreased mean corpuscular hemoglobin J:211773
impaired pupillary reflex J:211773
increased circulating alanine transaminase level J:211773
Elavl1tm1b(EUCOMM)Hmgu/Elavl1tm1b(EUCOMM)Hmgu
C57BL/6N-Elavl1tm1b(EUCOMM)Hmgu/J 		abnormal embryo size J:211773
abnormal limb morphology J:211773
anophthalmia J:211773
edema J:211773
embryonic growth retardation J:211773
preweaning lethality, complete penetrance J:211773
Elavl1tm1Dkon/Elavl1tm1Dkon
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal craniofacial bone morphology J:149149
abnormal lung development J:149149
abnormal spleen development J:149149
abnormal vertebrae development J:149149
absent spleen J:149149
delayed endochondral bone ossification J:149149
lethality throughout fetal growth and development, complete penetrance J:149149
midline facial cleft J:149149
short limbs J:149149
small limb buds J:149149
split xiphoid process J:149149
syndactyly J:149149
synostosis J:149149
Elavl1tm1Dkon/Elavl1tm1Dkon
Tg(Lck-cre)I57Jxm/0
B6.Cg-Elavl1tm1Dkon Tg(Lck-cre)I57Jxm 		abnormal positive T cell selection J:148866
abnormal T cell physiology J:148866
abnormal thymocyte activation J:148866
decreased CD4-positive, alpha-beta T cell number J:148866
decreased CD8-positive, alpha-beta T cell number J:148866
increased double-negative T cell number J:148866
increased double-positive T cell number J:148866
increased single-positive T cell number J:148866
Elavl1tm1Dkon/Elavl1tm1Dkon
Tg(Tie1-cre)9Ref/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:149149
Elavl1tm1Lix/Elavl1tm1Lix
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * C57BL/6 		decreased inflammatory response J:204952
lung inflammation J:204952
Elavl1tm1Thla/Elavl1tm1Thla
Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
involves: 129 		abnormal B cell physiology J:155109
abnormal colon morphology J:155109
abnormal crypts of Lieberkuhn morphology J:155109
abnormal definitive hematopoiesis J:155109
abnormal intestinal epithelium morphology J:155109
abnormal intestinal goblet cell morphology J:155109
abnormal intestinal mucosa morphology J:155109
abnormal myeloid leukocyte morphology J:155109
cachexia J:155109
decreased B cell apoptosis J:155109
decreased bone marrow cell number J:155109
decreased cell proliferation J:155109
decreased common myeloid progenitor cell number J:155109
decreased double-positive T cell number J:155109
decreased erythroid progenitor cell number J:155109
decreased granulocyte number J:155109
decreased leukocyte cell number J:155109
distended stomach J:155109
increased granulocyte number J:155109
increased T cell apoptosis J:155109
intestinal obstruction J:155109
lymph node hypoplasia J:155109
premature death J:155109
small intestinal villus atrophy J:155109
spleen hypoplasia J:155109
thymus hypoplasia J:155109
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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07/02/2024
MGI 6.13 		The Jackson Laboratory