About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Phox2b
paired-like homeobox 2b
MGI:1100882
75 phenotypes from 10 alleles in 17 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Egr2tm2(cre)Pch/Egr2+
Phox2btm4Jbr/Phox2b+
involves: 129S2/SvPas * C57BL/6 * DBA/2 		abnormal autonomic nervous system physiology J:176573
abnormal respiratory function J:176573
abnormal retrotrapezoid nucleus morphology J:176573
alkalemia J:176573
decreased pulmonary ventilation J:176573
normal mortality/aging J:176573
Isl1tm1(cre)Tmj/Isl1+
Phox2btm3.1Jbr/Phox2btm3.1Jbr
involves: 129S2/SvPas * 129X1/SvJ 		abnormal pterygopalatine ganglion morphology J:157532
absent petrosal ganglion J:157532
Phox2bDilp1/Phox2b+
involves: BALB/cAnN * C3H/HeN 		abnormal ciliary ganglion morphology J:91199
abnormal eye morphology J:75964
impaired pupillary reflex J:91199
mydriasis J:75964, J:91199
preweaning lethality, incomplete penetrance J:75964
Phox2bDilp1/Phox2bDilp1
involves: BALB/cAnN * C3H/HeN 		postnatal lethality J:75964
Phox2bem3(cre)Heno/Phox2b+
involves: 129 * C57BL/6 * C57BL/6N * DBA 		postnatal growth retardation J:344865
Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist
involves: 129S4/SvJae 		abnormal cardiovascular system morphology J:126634
abnormal cranial ganglia morphology J:126634
abnormal enteric nervous system morphology J:126634
abnormal locus ceruleus morphology J:126634
abnormal motor neuron morphology J:126634
abnormal nervous system morphology J:126634
abnormal noradrenaline level J:126634
abnormal parasympathetic ganglion morphology J:126634
abnormal vagus ganglion morphology J:126634
embryonic lethality during organogenesis, complete penetrance J:126634
small facial motor nucleus J:126634
small trigeminal ganglion J:126634
Phox2btm1.1Heno/Phox2b+
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * DBA/2) 		abnormal enteric ganglia morphology J:190742
abnormal enteric neural crest cell migration J:190742
abnormal glial cell morphology J:190742
abnormal neuron physiology J:190742
abnormal neuronal precursor proliferation J:190742
abnormal respiratory function J:190742
abnormal retrotrapezoid nucleus morphology J:190742
abnormal sympathetic ganglion morphology J:190742
abnormal vagus ganglion morphology J:190742
cyanosis J:190742
decreased enteric neural crest cell number J:190742
decreased enteric neural crest cell proliferation J:190742
decreased neuronal precursor cell number J:190742
impaired neuron differentiation J:190742
neonatal lethality, complete penetrance J:190742
small facial motor nucleus J:190742
Phox2btm1Jbr/Phox2b+
Not Specified 		abnormal ciliary ganglion morphology J:91199
abnormal pulmonary ventilation J:86516
decreased pulmonary ventilation J:86516
impaired pupillary reflex J:91199
mydriasis J:91199
Phox2btm1Jbr/Phox2btm1Jbr
Not Specified 		abnormal area postrema morphology J:86516
abnormal autonomic nervous system morphology J:55391
abnormal carotid body morphology J:86516
abnormal cranial ganglia morphology J:55391, J:86516
abnormal cranial nerve morphology J:60832
abnormal enteric ganglia morphology J:55391
abnormal geniculate ganglion morphology J:55391, J:86516
abnormal glossopharyngeal ganglion morphology J:55391
abnormal locus ceruleus morphology J:63723
abnormal medulla oblongata morphology J:86516
abnormal motor neuron morphology J:55391, J:60832
abnormal nodose ganglion morphology J:86516
abnormal noradrenaline level J:55391, J:63723
abnormal parasympathetic ganglion morphology J:55391
abnormal petrosal ganglion morphology J:86516
abnormal sympathetic ganglion morphology J:55391
abnormal vagus ganglion morphology J:55391
abnormal vagus nerve morphology J:60832
absent facial nerve J:60832
absent trigeminal nerve J:60832
blood vessel congestion J:63723
embryonic lethality during organogenesis, incomplete penetrance J:63723
lethality throughout fetal growth and development, complete penetrance J:63723
Phox2btm1Rth/Phox2b+
Hprt1tm1(CAG-cre)Mnn/?
involves: 129 * 129S1/Sv * C57BL/6 		abnormal facial nerve morphology J:331513
abnormal innervation J:331513
abnormal locus ceruleus morphology J:331513
abnormal nervous system electrophysiology J:331513
abnormal neuron morphology J:331513
abnormal trigeminal V mesencephalic nucleus morphology J:331513
abnormal vagus nerve morphology J:331513
cyanosis J:331513
perinatal lethality, complete penetrance J:331513
respiratory failure J:331513
Phox2btm1Rth/Phox2b+
Tg(Fabp7-cre,-lacZ)3Gtm/0
involves: 129 * C57BL/6 * CBA 		abnormal facial nerve morphology J:331513
abnormal retrotrapezoid nucleus morphology J:331513
abnormal suckling behavior J:331513
decreased pulmonary respiratory rate J:331513
normal nervous system phenotype J:331513
Phox2btm2.1Heno/Phox2b+
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * DBA/2) 		abnormal enteric ganglia morphology J:190742
abnormal enteric neural crest cell migration J:190742
abnormal glial cell morphology J:190742
abnormal neuron physiology J:190742
abnormal neuronal precursor proliferation J:190742
abnormal respiratory function J:190742
abnormal retrotrapezoid nucleus morphology J:190742
abnormal sympathetic ganglion morphology J:190742
cyanosis J:190742
decreased enteric neural crest cell number J:190742
decreased enteric neural crest cell proliferation J:190742
decreased neuronal precursor cell number J:190742
impaired neuron differentiation J:190742
neonatal lethality, complete penetrance J:190742
Phox2btm2Jbr/Phox2b+
involves: 129S2/SvPas 		abnormal neuron physiology J:155885
Phox2btm2Jbr/Phox2b+
involves: 129S2/SvPas * C57BL/6 		abnormal brain interneuron morphology J:131365
abnormal breathing pattern J:131365
abnormal lung volume J:131365
abnormal respiration J:131365
apnea J:131365
cyanosis J:131365
hypoventilation J:131365
neonatal lethality, complete penetrance J:131365
respiratory failure J:131365
Phox2btm3.1Jbr/Phox2btm3.1Jbr
involves: 129S2/SvPas * C57BL/6 * DBA/2 		no abnormal phenotype detected J:155885
Phox2btm3.1Jbr/Phox2btm3.1Jbr
Egr2tm2(cre)Pch/Egr2+
involves: 129S2/SvPas * C57BL/6 * DBA/2 		abnormal neuron differentiation J:155885
abnormal neuron physiology J:155885
postnatal lethality, complete penetrance J:155885
Phox2btm3.1Jbr/Phox2btm3.1Jbr
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S2/SvPas * C57BL/6J * CBA/J 		abnormal parasympathetic ganglion morphology J:157532
Phox2btm3.1Jbr/Phox2btm3.1Jbr
Isl1tm1(cre)Tmj/Isl1+
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal neuron differentiation J:155885
abnormal neuron physiology J:155885
decreased body size J:155885
postnatal lethality, complete penetrance J:155885
Phox2btm3.1Jbr/Phox2btm3.1Jbr
Tg(Pgk1-cre)1Lni/0
involves: 129S2/SvPas * BALB/c * C57BL/6 * DBA/2 		embryonic lethality during organogenesis, complete penetrance J:155885
Phox2btm3.1Jbr/Phox2btm3.1Jbr
Tg(Pou3f4-cre)32Cren/0
involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 		abnormal nervous system morphology J:155885
Phox2btm3.1Jbr/Phox2btm3.1Jbr
Tg(Pou3f4-cre)32Cren/0
involves: 129S2/SvPas * CD-1 		abnormal motor neuron morphology J:157532
normal nervous system phenotype J:157532
Phox2btm4Jbr/Phox2b+
Tg(Pou3f4-cre)32Cren/0
involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 		neonatal lethality, complete penetrance J:176573
Phox2btm4Jbr/Phox2b+
Tg(Pgk1-cre)1Lni/0
involves: 129S2/SvPas * BALB/c * C57BL/6 		abnormal respiration J:155885
Phox2btm4Jbr/Phox2b+
Tg(Pgk1-cre)1Lni/0
involves: 129S2/SvPas * BALB/c * C57BL/6 * DBA/2 		abnormal retrotrapezoid nucleus morphology J:176573
neonatal lethality, complete penetrance J:176573
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory