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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kl
klotho
MGI:1101771
166 phenotypes from 10 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Klecalc1/Klecalc1
involves: C3H/HeH * C57BL/6J 		abnormal aorta wall morphology J:229255
abnormal circulating protein level J:229255
abnormal femur morphology J:229255
abnormal incus morphology J:229255
abnormal long bone epiphyseal plate proliferative zone J:229255
abnormal malleus manubrium morphology J:229255
abnormal malleus morphology J:229255
abnormal middle ear ossicle morphology J:229255
abnormal rib morphology J:229255
abnormal vertebrae morphology J:229255
absent pinna reflex J:229255
calcified aorta J:229255
calcified pulmonary alveolus J:229255
calcified skin J:229255
calcinosis J:229255
decreased body size J:229255
decreased bone mineral content J:229255
decreased bone mineral density of femur J:229255
decreased circulating glucose level J:229255
decreased circulating serum albumin level J:229255
decreased femur compact bone thickness J:229255
decreased long bone epiphyseal plate size J:229255
decreased subcutaneous adipose tissue amount J:229255
decreased width of hypertrophic chondrocyte zone J:229255
emphysema J:229255
hunched posture J:229255
impaired hearing J:229255
increased alkaline phosphatase activity J:229255
increased circulating phosphate level J:229255
increased vitamin D level J:229255
kyphoscoliosis J:229255
lung inflammation J:229255
nephrocalcinosis J:229255
postnatal growth retardation J:229255
premature death J:229255
renal necrosis J:229255
short femur J:229255
short malleus J:229255
short malleus manubrium J:229255
skin atrophy J:229255
small stapes obturator foramen J:229255
thick zygomatic arch J:229255
thin epidermis J:229255
wide ribs J:229255
Klecalc2/Klecalc2
involves: C3H/HeH * C57BL/6J 		abnormal femur morphology J:229255
absent pinna reflex J:229255
calcinosis J:229255
decreased body size J:229255
decreased femur compact bone thickness J:229255
hunched posture J:229255
impaired hearing J:229255
kyphoscoliosis J:229255
postnatal growth retardation J:229255
premature death J:229255
short femur J:229255
thick zygomatic arch J:229255
wide ribs J:229255
Klem1Btlr/Klem1Btlr
C57BL/6J-Klem1Btlr/Btlr 		short femur J:309727
short tibia J:309727
small pubis J:309727
Klkl/Kl+
involves: C3H/HeJ * C57BL/6J 		abnormal blood vessel physiology J:76383
alopecia J:59775
calcified pulmonary alveolus J:59775
decreased circulating insulin level J:64878
decreased insulin secretion J:64878
emphysema J:59775
hypoglycemia J:64878
kyphosis J:59775
Klkl/Klkl
either: C.Cg-Klkl or (involves: C3H/HeJ * C57BL/6J) 		abnormal adenohypophysis morphology J:44109
abnormal blood circulation J:44109
abnormal bone ossification J:44109
abnormal bone structure J:44109
abnormal circulating mineral level J:44109
abnormal gametogenesis J:44109
abnormal gonadotroph morphology J:44109
abnormal leukocyte cell number J:44109
abnormal seminiferous tubule morphology J:44109
abnormal skin condition J:44109
absent mature ovarian follicles J:44109
arrest of male meiosis J:44109
arteriosclerosis J:44109
azoospermia J:44109
calcified aorta J:44109
calcified artery J:44109
calcified muscle J:44109
calcified pulmonary alveolus J:44109
calcified skin J:44109
calcinosis J:44109
decreased bone mineral density J:44109
decreased compact bone thickness J:44109
decreased hair follicle number J:44109
decreased insulin secretion J:44109
decreased locomotor activity J:44109
decreased osteoclast cell number J:44109
decreased Purkinje cell number J:44109
decreased somatotroph cell size J:44109
decreased somatotroph secretory granule number J:44109
decreased subcutaneous adipose tissue amount J:44109
emphysema J:44109
external male genitalia atrophy J:44109
hypoglycemia J:44109
increased circulating calcium level J:44109
infertility J:44109
kyphosis J:44109
osteoporosis J:44109
ovary atrophy J:44109
postnatal growth retardation J:44109
premature aging J:44109
premature death J:44109
Purkinje cell degeneration J:44109
short stride length J:44109
sparse hair J:44109
testicular atrophy J:44109
thin epidermis J:44109
thymus atrophy J:44109
uterus atrophy J:44109
vulva atrophy J:44109
Klkl/Klkl
involves: 129S1/SvImJ * C3H/HeJ * C57BL/6J 		abnormal retina morphology J:214493
decreased a-wave amplitude J:214493
decreased b-wave amplitude J:214493
increased a-wave latency J:214493
increased b-wave latency J:214493
Klkl/Klkl
involves: C3H/HeJ * C57BL/6J 		abnormal contextual conditioning behavior J:81240
abnormal cued conditioning behavior J:81240
abnormal nervous system physiology J:81240
decreased B cell number J:80503
decreased body weight J:80503
decreased circulating insulin level J:64878
decreased insulin secretion J:64878
decreased osteoclast cell number J:80503
hypoglycemia J:64878
impaired long-term object recognition memory J:81240
increased insulin sensitivity J:64878
osteopetrosis J:80503
oxidative stress J:81240
postnatal growth retardation J:81240
premature death J:81240
short femur J:80503
Klkl/Klkl
involves: C3H/J * C57BL/6J 		abnormal bone mineral density J:56666
abnormal cardiovascular system physiology J:102218
abnormal glucose homeostasis J:66078
abnormal heart valve morphology J:102218
abnormal liver physiology J:66078
abnormal lung morphology J:59775
abnormal osteoblast morphology J:56666
abnormal osteoblast physiology J:56666
abnormal osteoclast morphology J:56666
abnormal pancreatic beta cell morphology J:66078
abnormal pulmonary alveolus morphology J:59775
abnormal pulmonary interalveolar septum morphology J:59775
abnormal respiratory mechanics J:59775
abnormal sinoatrial node conduction J:102218
abnormal trabecular bone morphology J:56666
arteriosclerosis J:102218
calcified aortic valve annulus J:102218
calcified mitral valve annulus J:102218
decreased body length J:59775
decreased body temperature J:66078
decreased bone mineral density J:56666
decreased bone mineral density of femur J:56666
decreased bone ossification J:56666
decreased bone resorption J:56666
decreased brown fat cell lipid droplet size J:66078
decreased circulating insulin level J:66078
decreased compact bone thickness J:56666
decreased femur compact bone thickness J:56666
decreased heart rate J:102218
decreased liver weight J:66078
decreased osteoblast cell number J:56666
decreased tidal volume J:59775
decreased white adipose tissue amount J:66078
dilated pulmonary alveolar duct J:59775
emphysema J:59775
hypoglycemia J:66078
improved glucose tolerance J:66078
increased brown adipose tissue amount J:66078
increased circulating noradrenaline level J:102218
increased insulin sensitivity J:66078
increased lung compliance J:59775
increased susceptibility to induced morbidity/mortality J:102218
postnatal growth retardation J:66078
prolonged RR interval J:102218
small pancreatic islets J:66078
Klm1Anu/Klm1Anu
C57BL/6NCrlAnu-Klm1Anu 		abnormal autopod morphology J:104190
abnormal definitive hematopoiesis J:104190
abnormal duodenum morphology J:104190
abnormal heart morphology J:104190
abnormal kidney collecting duct morphology J:104190
abnormal kidney cortex morphology J:104190
abnormal kidney medulla morphology J:104190
abnormal kidney morphology J:104190
abnormal smooth muscle morphology J:104190
abnormal spleen morphology J:104190
abnormal stomach morphology J:104190
abnormal tracheal cartilage morphology J:104190
absent bone trabeculae J:104190
dehydration J:104190
diaphragmatic hernia J:104190
dilated gastric gland J:104190
hemorrhage J:104190
increased circulating calcium level J:104190
respiratory distress J:104190
small spleen J:104190
Kltm1.1Tel/Kltm1.1Tel
Tg(Cdh16-cre)91Igr/0
involves: C57BL/6 * ICR 		decreased circulating parathyroid hormone level J:201719
normal homeostasis/metabolism phenotype J:201719
increased circulating parathyroid hormone level J:201719
increased circulating phosphate level J:201719
increased urine calcium level J:201719
Kltm1.2Tel/Kltm1.2Tel
involves: C57BL/6 * FVB/N 		abnormal kidney morphology J:201719
decreased body size J:201719
decreased locomotor activity J:201719
increased circulating calcium level J:201719
increased circulating phosphate level J:201719
kidney cortex hypoplasia J:201719
kyphosis J:201719
nephrocalcinosis J:201719
postnatal growth retardation J:201719
premature death J:201719
renal fibrosis J:201719
small kidney J:201719
Kltm1Lex/Kltm1Lex
B6.129S-Kltm1Lex 		decreased body size J:173962
increased circulating calcium level J:173962
increased circulating phosphate level J:173962
Kltm1Lex/Kltm1Lex
involves: 129S5/SvEvBrd * C57BL/6J 		abnormal femur morphology J:103485
abnormal trabecular bone morphology J:103485
decreased body length J:103485
decreased body weight J:103485
premature death J:103485
Kltm1Yin/Kltm1Yin
Not Specified 		abnormal long bone epiphysis morphology J:86859
abnormal vitamin D level J:86859
decreased body weight J:86859
decreased bone mineral density J:86859
decreased white adipose tissue amount J:86859
increased circulating calcium level J:86859
increased circulating phosphate level J:86859
postnatal growth retardation J:86859
premature death J:86859
Kltm2Yin/Kltm2Yin
involves: 129S/SvEv 		decreased heart rate J:102218
increased susceptibility to induced morbidity/mortality J:102218
premature aging J:102218
premature death J:102218
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory