Diaph1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Diaph1
diaphanous related formin 1
MGI:1194490

45 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Diaph1^{em1(IMPC)Rbrc}/Diaph1^{em1(IMPC)Rbrc} C57BL/6NJcl-Diaph1^{em1(IMPC)Rbrc}/Rbrc	increased blood urea nitrogen level	J:211773
Diaph1^M1Btlr/Diaph1⁺ C57BL/6J-Diaph1^M1Btlr	abnormal CD4-positive, alpha-beta T cell number	J:254820
	abnormal CD8-positive, alpha-beta T cell number	J:254820
	decreased IgE level	J:254820
	increased central memory CD4-positive, alpha-beta T cell number	J:254820
	increased central memory CD8 positive, alpha-beta T cell number	J:254820
Diaph1^M1Btlr/Diaph1^M1Btlr C57BL/6J-Diaph1^M1Btlr	abnormal CD4-positive, alpha-beta T cell number	J:254820
	abnormal CD8-positive, alpha-beta T cell number	J:254820
	decreased effector memory CD8-positive, alpha-beta T cell number	J:254820
	decreased IgE level	J:254820
	increased central memory CD4-positive, alpha-beta T cell number	J:254820
	increased central memory CD8 positive, alpha-beta T cell number	J:254820
	increased susceptibility to Herpesvirales infection induced morbidity/mortality	J:254820
Diaph1^M2Btlr/Diaph1⁺ C57BL/6J-Diaph1^M2Btlr	decreased B-1 B cell number	J:254819
Diaph1^M2Btlr/Diaph1^M2Btlr C57BL/6J-Diaph1^M2Btlr	decreased B-1 B cell number	J:254819
Diaph1^M2Btlr/Diaph1^M2Btlr C57BL/6J-Diaph1^M2Btlr	decreased CD8-positive, alpha-beta memory T cell number	J:254819
Diaph1^m3Btlr/Diaph1^m3Btlr C57BL/6J-Diaph1^m3Btlr	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:254818
	decreased CD8-positive, naive alpha-beta T cell number	J:254818
	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:254818
	increased CD8-positive, alpha-beta memory T cell number	J:254818
	increased central memory CD4-positive, alpha-beta T cell number	J:254818
	increased central memory CD8 positive, alpha-beta T cell number	J:254818
	increased effector memory CD4-positive, alpha-beta T cell number	J:254818
	increased effector memory CD8-positive, alpha-beta T cell number	J:254818
Diaph1^tm1.1Sna/Diaph1^tm1.1Sna B6.Cg-Diaph1^tm1.1Sna	abnormal humoral immune response	J:126090
	abnormal leukocyte migration	J:126090
	decreased CD4-positive, alpha-beta T cell number	J:126090
	decreased CD8-positive, alpha-beta T cell number	J:126090
	decreased T cell number	J:126090
	decreased T cell proliferation	J:126090
	increased single-positive T cell number	J:126090
Diaph1^tm1Asal/Diaph1⁺ involves: 129S1/Sv * C57BL/6	abnormal bone marrow cell morphology/development	J:124319
	abnormal definitive hematopoiesis	J:124319
	increased bone marrow cell number	J:124319
Diaph1^tm1Asal/Diaph1^tm1Asal involves: 129S1/Sv * C57BL/6	abnormal bone marrow cell morphology/development	J:124319
	abnormal definitive hematopoiesis	J:124319
	abnormal lymph node morphology	J:124319
	abnormal skin condition	J:124319
	abnormal spleen germinal center morphology	J:124319
	abnormal spleen morphology	J:124319
	absent spleen white pulp	J:124319
	alopecia	J:124319
	anemia	J:124319
	decreased lymphocyte cell number	J:124319
	dehydration	J:124319
	dermatitis	J:124319
	echinocytosis	J:124319
	extramedullary hematopoiesis	J:124319
	increased bone marrow cell number	J:124319
	increased granulocyte number	J:124319
	increased leukocyte cell number	J:124319
	increased monocyte cell number	J:124319
	increased neutrophil cell number	J:124319
	increased spleen weight	J:124319
	malocclusion	J:124319
	postnatal growth retardation	J:124319

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