Irs3 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irs3
insulin receptor substrate 3
MGI:1194882

15 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Irs1^tm1Jos/Irs1^tm1Jos Irs3^tm1Lhd/Irs3^tm1Lhd involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	abnormal gonadal fat pad morphology	J:80976
	decreased circulating free fatty acids level	J:80976
	decreased circulating leptin level	J:80976
	decreased circulating triglyceride level	J:80976
	decreased triglyceride level	J:80976
	decreased white adipose tissue amount	J:80976
	hyperglycemia	J:80976
	impaired glucose tolerance	J:80976
	increased circulating insulin level	J:80976
	increased pancreatic beta cell mass	J:80976
	insulin resistance	J:80976
	normal liver/biliary system phenotype	J:80976
	normal mortality/aging	J:80976
	pancreatic islet hyperplasia	J:80976
	postnatal growth retardation	J:80976

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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