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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Terf2
telomeric repeat binding factor 2
MGI:1195972
35 phenotypes from 5 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Terf2tm1.1Tdl/Terf2tm1.1Tdl
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality, complete penetrance J:105516
Terf2tm1Tdl/Terf2tm1.1Tdl
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA 		abnormal chromosome morphology J:112957
abnormal hepatocyte morphology J:112957
Tg(KRT5-Terf2)PMBlas/Y
involves: C57BL/6 * CBA 		abnormal DNA repair J:102653
abnormal epidermal pigmentation J:102653
abnormal keratinocyte physiology J:102653
abnormal skin morphology J:102653
abnormal telomere morphology J:102653
chromosomal instability J:102653
decreased keratinocyte proliferation J:102653
decreased telomere length J:102653
dry skin J:102653
epidermal atrophy J:102653
epidermal hyperplasia J:102653
focal dorsal hair loss J:102653
hair follicle degeneration J:102653
increased cellular sensitivity to alkylating agents J:102653
increased cellular sensitivity to ultraviolet irradiation J:102653
increased ear pigmentation J:102653
increased foot pigmentation J:102653
increased incidence of tumors by UV-induction J:102653
increased keratoacanthoma incidence J:102653
increased sensitivity to skin irradiation J:102653
increased skin pigmentation J:102653
increased skin squamous cell carcinoma incidence J:102653
increased skin tumor incidence J:102653
increased tail pigmentation J:102653
induced chromosome breakage J:102653
premature aging J:102653
prenatal lethality, incomplete penetrance J:102653
sebaceous gland atrophy J:102653
skin hyperplasia J:102653
skin photosensitivity J:102653
Tg(KRT5-Terf2)PNBlas/0
involves: C57BL/6 * CBA 		decreased telomere length J:102653
increased ear pigmentation J:102653
increased foot pigmentation J:102653
increased skin pigmentation J:102653
increased tail pigmentation J:102653
normal mortality/aging J:102653
normal neoplasm J:102653
Tg(KRT5-Terf2)POBlas/0
involves: C57BL/6 * CBA 		abnormal DNA repair J:102653
abnormal keratinocyte physiology J:102653
chromosomal instability J:102653
decreased telomere length J:102653
increased cellular sensitivity to alkylating agents J:102653
increased cellular sensitivity to ultraviolet irradiation J:102653
increased ear pigmentation J:102653
increased foot pigmentation J:102653
increased incidence of tumors by UV-induction J:102653
increased keratoacanthoma incidence J:102653
increased sensitivity to skin irradiation J:102653
increased skin pigmentation J:102653
increased skin squamous cell carcinoma incidence J:102653
increased skin tumor incidence J:102653
increased tail pigmentation J:102653
induced chromosome breakage J:102653
normal mortality/aging J:102653
skin photosensitivity J:102653
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory