Cdk8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdk8
cyclin dependent kinase 8
MGI:1196224

19 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdk8^{GT(RRS314)Byg}/Cdk8^{GT(RRS314)Byg} involves: 129P2/OlaHsd * CD-1	abnormal preimplantation embryo development	J:125327
	embryonic lethality before implantation, complete penetrance	J:125327
	failure of morula compaction	J:125327
Cdk8^{tm1a(EUCOMM)Hmgu}/Cdk8^{tm1a(EUCOMM)Hmgu} Tg(Ins2-cre)23Herr/0 involves: C57BL/6J * C57BL/6N * CBA/J	abnormal pancreatic beta cell physiology	J:281075
	decreased body weight	J:281075
	decreased circulating insulin level	J:281075
	decreased pancreatic beta cell mass	J:281075
	improved glucose tolerance	J:281075
	increased cellular sensitivity to oxidative stress	J:281075
	increased circulating glucose level	J:281075
	increased insulin secretion	J:281075
	increased pancreatic beta cell apoptosis	J:281075
Cdk8^{tm1a(EUCOMM)Hmgu}/Cdk8^{tm1a(EUCOMM)Hmgu} Tg(Pdx1-cre)6Tuv/0 involves: C57BL/6N * FVB/N	improved glucose tolerance	J:281075
	increased insulin secretion	J:281075
Cdk8^{tm1b(EUCOMM)Hmgu}/Cdk8⁺ C57BL/6N-Cdk8^{tm1b(EUCOMM)Hmgu}/Ics	abnormal freezing behavior	J:211773
	decreased exploration in new environment	J:211773
Cdk8^{tm1b(EUCOMM)Hmgu}/Cdk8^{tm1b(EUCOMM)Hmgu} C57BL/6N-Cdk8^{tm1b(EUCOMM)Hmgu}/Ics	abnormal embryo size	J:211773
	abnormal embryo turning	J:211773
	abnormal heart morphology	J:211773
	abnormal neural tube closure	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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