Kdm1a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Kdm1a
lysine (K)-specific demethylase 1A
MGI:1196256

80 phenotypes from 9 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm2(H1/tetO-RNAi:Kdm1a)Arte}/Gt(ROSA)26Sor⁺ involves: C57BL/6	abnormal bone marrow cell morphology/development	J:192055
	abnormal erythropoiesis	J:192055
	abnormal granulocyte differentiation	J:192055
	abnormal megakaryocyte morphology	J:192055
	abnormal megakaryocyte progenitor cell morphology	J:192055
	abnormal monocyte differentiation	J:192055
	abnormal platelet morphology	J:192055
	abnormal proerythroblast morphology	J:192055
	anemia	J:192055
	decreased erythroid progenitor cell number	J:192055
	enlarged spleen	J:192055
	normal hematopoietic system phenotype	J:192055
	increased circulating erythropoietin level	J:192055
	increased erythroid progenitor cell number	J:192055
	increased hematopoietic stem cell number	J:192055
	increased hematopoietic stem cell proliferation	J:192055
	increased leukocyte cell number	J:192055
	increased mean platelet volume	J:192055
	increased megakaryocyte cell number	J:192055
Kdm1a^{Gt(RRK075)Byg}/Kdm1a^{Gt(RRK075)Byg} involves: 129P2/OlaHsd * C57BL/6	abnormal gastrulation	J:169674
	embryonic lethality between implantation and placentation, incomplete penetrance	J:169674
	embryonic lethality during organogenesis, complete penetrance	J:169674
Kdm1a^{Gt(RRK075)Byg}/Kdm1a^tm1.2Rsd involves: 129P2/OlaHsd * C57BL/6	abnormal gastrulation	J:169674
	prenatal lethality, complete penetrance	J:169674
Kdm1a^{tm1(NCOM)Mfgc}/Kdm1a⁺ C57BL/6N-Kdm1a^{tm1(NCOM)Mfgc}/Nju	decreased grip strength	J:211773
	decreased locomotor activity	J:211773
	increased basophil cell number	J:211773
	increased eosinophil cell number	J:211773
	increased mean platelet volume	J:211773
	small heart	J:211773
	small kidney	J:211773
	small liver	J:211773
	small lung	J:211773
	small spleen	J:211773
Kdm1a^{tm1(NCOM)Mfgc}/Kdm1a^{tm1(NCOM)Mfgc} C57BL/6N-Kdm1a^{tm1(NCOM)Mfgc}/Nju	preweaning lethality, complete penetrance	J:211773
Kdm1a^tm1.1Rsd/Kdm1a^tm1.1Rsd Tg(Pitx1-cre)7Rsd/0 involves: BALB/c * C57BL/6	abnormal cell cycle	J:121427
	abnormal luteinizing hormone level	J:121427
	abnormal pituitary gland development	J:121427
	abnormal pituitary hormone level	J:121427
	decreased growth hormone level	J:121427
	decreased thyroid-stimulating hormone level	J:121427
	normal nervous system phenotype	J:121427
Kdm1a^tm1.1Sbae/Kdm1a^tm1.1Sbae B6.Cg-Kdm1a^tm1.1Sbae	abnormal circadian behavior persistence	J:210640
	abnormal circardian behavior entrainment	J:210640
	normal behavior/neurological phenotype	J:210640
Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca	abnormal definitive hematopoiesis	J:201572
	decreased body size	J:201572
	decreased bone marrow cell number	J:201572
	decreased common myeloid progenitor cell number	J:201572
	decreased erythrocyte cell number	J:201572
	decreased hematopoietic stem cell number	J:201572
	decreased leukocyte cell number	J:201572
	postnatal lethality, incomplete penetrance	J:201572
	thrombocytopenia	J:201572
Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺ involves: 129 * BALB/cJ	abnormal erythropoiesis	J:201572
	abnormal liver morphology	J:201572
	abnormal proerythroblast morphology	J:201572
	decreased embryo size	J:201572
	decreased fetal derived definitive erythrocyte cell number	J:201572
	pale liver	J:201572
	reticulocytopenia	J:201572
Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Tg(Mx1-cre)1Cgn/? involves: 129 * C57BL/6 * CBA/Ca	abnormal common myeloid progenitor cell morphology	J:201572
	abnormal definitive hematopoiesis	J:201572
	abnormal induced morbidity/mortality	J:201572
	decreased common myeloid progenitor cell number	J:201572
	decreased granulocyte number	J:201572
	decreased hematopoietic stem cell number	J:201572
	decreased neutrophil cell number	J:201572
	increased hematopoietic stem cell number	J:201572
	pancytopenia	J:201572
Kdm1a^tm1.1Tche/Kdm1a^tm1.1Tche Not Specified	abnormal heart development	J:270116
	abnormal mitral valve morphology	J:270116
	cardiac muscle degeneration	J:270116
	lethality during fetal growth through weaning, complete penetrance	J:270116
	perimembraneous ventricular septal defect	J:270116
	perinatal lethality, complete penetrance	J:270116
Kdm1a^tm1.1Tche/Kdm1a^tm1.2Tche Not Specified	ventricular septal defect	J:270116
Kdm1a^tm1.2Rsd/Kdm1a^tm1.2Rsd Not Specified	abnormal gastrulation	J:169674
	embryonic lethality between implantation and somite formation, complete penetrance	J:121427
	lethality during fetal growth through weaning, complete penetrance	J:169674
Kdm1a^tm1.2Tche/Kdm1a⁺ involves: 129 * C57BL/6	no abnormal phenotype detected	J:144527
Kdm1a^tm1.2Tche/Kdm1a^tm1.2Tche involves: 129 * C57BL/6	absent egg cylinders	J:144527
	embryonic growth arrest	J:144527
	embryonic lethality between implantation and somite formation, complete penetrance	J:144527
	failure to gastrulate	J:144527
	increased apoptosis	J:144527
Kdm1a^tm1Ebg/Kdm1a^tm1Ebg B6.129-Kdm1a^tm1Ebg	abnormal brain wave pattern	J:235553
	absence seizures	J:235553
	decreased susceptibility to pharmacologically induced seizures	J:235553
	decreased susceptibility to xenobiotic induced morbidity/mortality	J:235553
	normal nervous system phenotype	J:235553
	tonic-clonic seizures	J:235553

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