About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tsc22d3
TSC22 domain family, member 3
MGI:1196284
41 phenotypes from 5 alleles in 6 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Tsc22d3tm1.1Hum/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129S1/SvImJ * C57BL/6N * SJL/J 		normal reproductive system phenotype J:226675
Tsc22d3tm1.1Hum/Y
Tg(Ddx4-cre)1Dcas/0
involves: 129S1/SvImJ * C57BL/6N * FVB 		abnormal seminiferous tubule epithelium morphology J:226675
azoospermia J:226675
male infertility J:226675
small testis J:226675
Tsc22d3tm1.1Ric/Y
involves: 129S7/SvEvBrd * C57BL/6 		abnormal spermatid morphology J:179667
abnormal spermatogenesis J:179667
abnormal spermatogonia proliferation J:179667
abnormal testis size J:179667
arrest of male meiosis J:179667
azoospermia J:179667
decreased male germ cell number J:179667
male infertility J:179667
Tsc22d3tm1.2Efmd/Y
Not Specified 		abnormal susceptibility to autoimmune disorder J:201728
abnormal T cell subpopulation ratio J:201728
normal immune system phenotype J:201728
increased interferon-gamma secretion J:201728
increased interleukin-17 secretion J:201728
increased susceptibility to type IV hypersensitivity reaction J:201728
male infertility J:201728
Tsc22d3tm1.2Hum/Y
involves: 129S1/SvImJ 		abnormal adipose tissue physiology J:223992
abnormal circulating hormone level J:223992
abnormal circulating sodium level J:223992
abnormal glucose homeostasis J:223992
abnormal ion homeostasis J:223992
abnormal seminiferous tubule epithelium morphology J:226675
abnormal spermatogenesis J:226675
abnormal thymus cell ratio J:223992
arrest of male meiosis J:226675
arrest of spermatogenesis J:226675
azoospermia J:223992, J:226675
decreased body weight J:223992
decreased circulating corticosterone level J:223992
decreased DN3 thymocyte number J:223992
decreased percent body fat/body weight J:223992
decreased susceptibility to diet-induced hepatic steatosis J:223992
decreased testis weight J:223992, J:226675
decreased thymus weight J:223992
increased circulating follicle stimulating hormone level J:223992
increased circulating insulin level J:223992
increased circulating potassium level J:223992
increased circulating testosterone level J:223992
increased DN4 thymocyte number J:223992
increased erythroblast number J:223992
increased Leydig cell number J:223992
increased male germ cell apoptosis J:226675
increased pancreatic alpha cell number J:223992
increased Sertoli cell number J:223992
male infertility J:223992, J:226675
Tsc22d3tm1.2Hum/Tsc22d3+
involves: 129S1/SvImJ 		normal reproductive system phenotype J:223992
Tsc22d3tm1.2Hum/Tsc22d3tm1.2Hum
involves: 129S1/SvImJ 		normal reproductive system phenotype J:226675
Tsc22d3tm1Ric/Y
Tg(Ddx4-cre)1Dcas/?
involves: C57BL/6 * FVB 		abnormal spermatid morphology J:179667
abnormal spermatogenesis J:179667
abnormal testis size J:179667
arrest of male meiosis J:179667
azoospermia J:179667
decreased male germ cell number J:179667
male infertility J:179667
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory