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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tsc22d3
TSC22 domain family, member 3
MGI:1196284
41 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tsc22d3tm1.1Hum/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129S1/SvImJ * C57BL/6N * SJL/J 		normal reproductive system phenotype J:226675
Tsc22d3tm1.1Hum/Y
Tg(Ddx4-cre)1Dcas/0
involves: 129S1/SvImJ * C57BL/6N * FVB 		abnormal seminiferous tubule epithelium morphology J:226675
azoospermia J:226675
male infertility J:226675
small testis J:226675
Tsc22d3tm1.1Ric/Y
involves: 129S7/SvEvBrd * C57BL/6 		abnormal spermatid morphology J:179667
abnormal spermatogenesis J:179667
abnormal spermatogonia proliferation J:179667
abnormal testis size J:179667
arrest of male meiosis J:179667
azoospermia J:179667
decreased male germ cell number J:179667
male infertility J:179667
Tsc22d3tm1.2Efmd/Y
Not Specified 		abnormal susceptibility to autoimmune disorder J:201728
abnormal T cell subpopulation ratio J:201728
normal immune system phenotype J:201728
increased interferon-gamma secretion J:201728
increased interleukin-17 secretion J:201728
increased susceptibility to type IV hypersensitivity reaction J:201728
male infertility J:201728
Tsc22d3tm1.2Hum/Y
involves: 129S1/SvImJ 		abnormal adipose tissue physiology J:223992
abnormal circulating hormone level J:223992
abnormal circulating sodium level J:223992
abnormal glucose homeostasis J:223992
abnormal ion homeostasis J:223992
abnormal seminiferous tubule epithelium morphology J:226675
abnormal spermatogenesis J:226675
abnormal thymus cell ratio J:223992
arrest of male meiosis J:226675
arrest of spermatogenesis J:226675
azoospermia J:223992, J:226675
decreased body weight J:223992
decreased circulating corticosterone level J:223992
decreased DN3 thymocyte number J:223992
decreased percent body fat/body weight J:223992
decreased susceptibility to diet-induced hepatic steatosis J:223992
decreased testis weight J:223992, J:226675
decreased thymus weight J:223992
increased circulating follicle stimulating hormone level J:223992
increased circulating insulin level J:223992
increased circulating potassium level J:223992
increased circulating testosterone level J:223992
increased DN4 thymocyte number J:223992
increased erythroblast number J:223992
increased Leydig cell number J:223992
increased male germ cell apoptosis J:226675
increased pancreatic alpha cell number J:223992
increased Sertoli cell number J:223992
male infertility J:223992, J:226675
Tsc22d3tm1.2Hum/Tsc22d3+
involves: 129S1/SvImJ 		normal reproductive system phenotype J:223992
Tsc22d3tm1.2Hum/Tsc22d3tm1.2Hum
involves: 129S1/SvImJ 		normal reproductive system phenotype J:226675
Tsc22d3tm1Ric/Y
Tg(Ddx4-cre)1Dcas/?
involves: C57BL/6 * FVB 		abnormal spermatid morphology J:179667
abnormal spermatogenesis J:179667
abnormal testis size J:179667
arrest of male meiosis J:179667
azoospermia J:179667
decreased male germ cell number J:179667
male infertility J:179667
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory