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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nus1
NUS1 dehydrodolichyl diphosphate synthase subunit
MGI:1196365
32 phenotypes from 4 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj
Nus1tm1.1Qrm/Nus1tm1.1Qrm
involves: 129 * C57BL/6 * SJL 		abnormal lipid homeostasis J:243753
hepatic steatosis J:243753
increased liver free fatty acids level J:243753
increased liver triglyceride level J:243753
Nus1tm1.1Qrm/Nus1tm1.1Qrm
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129 * C57BL/6 * DBA * SJL 		abnormal circulating cholesterol level J:243753
abnormal lipid homeostasis J:243753
decreased liver cholesterol level J:243753
increased circulating free fatty acids level J:243753
increased circulating triglyceride level J:243753
increased liver free fatty acids level J:243753
increased liver triglyceride level J:243753
Nus1tm1.1Qrm/Nus1tm1.1Qrm
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal brain vasculature morphology J:229464
abnormal vascular development J:229464
decreased embryo size J:229464
Nus1tm1.1Qrm/Nus1tm1.1Qrm
Tg(Tek-cre)1Ywa/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal brain vasculature morphology J:229464
abnormal vascular development J:229464
abnormal vitelline vasculature morphology J:229464
decreased embryo size J:229464
embryonic lethality during organogenesis, complete penetrance J:229464
Nus1tm1.1Wcsa/Nus1tm1.1Wcsa
involves: 129S4/SvJae 		embryonic lethality, complete penetrance J:215785
Nus1tm1.2Qrm/Nus1+
involves: 129P2/OlaHsd * FVB/N 		abnormal vascular development J:229464
Nus1tm1.2Qrm/Nus1tm1.2Qrm
involves: 129P2/OlaHsd * FVB/N 		embryonic lethality between implantation and somite formation, complete penetrance J:229464
Nus1tm1Wcsa/Nus1tm1.1Wcsa
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		abnormal cell physiology J:215785
abnormal cellular cholesterol metabolism J:215785
increased sensitivity to induced cell death J:215785
Nus1tm1Wcsa/Nus1tm1Wcsa
Not Specified 		abnormal lung endothelial cell physiology J:230506
decreased lung endothelial cell proliferation J:230506
increased lung endothelial cell apoptosis J:230506
Nus1tm1Wcsa/Nus1tm1Wcsa
Tg(Cdh5-cre/ERT2)1Rha/0
Not Specified 		abnormal jugular lymph sac morphology J:230506
abnormal vascular development J:230506
abnormal vitelline vasculature morphology J:230506
decreased endothelial cell proliferation J:230506
embryonic lethality, complete penetrance J:230506
hemorrhage J:230506
increased vascular endothelial cell apoptosis J:230506
subcutaneous edema J:230506
Nus1tm1Wcsa/Nus1tm1Wcsa
Tg(Tek-cre)12Flv/0
involves: C3H * C57BL/6 		abnormal embryo morphology J:230506
abnormal placenta vasculature J:230506
abnormal vascular endothelial cell physiology J:230506
abnormal visceral yolk sac physiology J:230506
abnormal vitelline vasculature morphology J:230506
decreased embryo size J:230506
embryonic lethality during organogenesis, complete penetrance J:230506
excessive folding of visceral yolk sac J:230506
thin placenta labyrinth J:230506
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory