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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfaip3
tumor necrosis factor, alpha-induced protein 3
MGI:1196377
107 phenotypes from 9 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Tnfaip3tm2Ama/Tnfaip3+
involves: 129P2/OlaHsd * C57BL/6 		decreased B cell apoptosis J:163917
increased autoantibody level J:163917
increased germinal center B cell number J:163917
increased immunoglobulin level J:163917
increased plasma cell number J:163917
increased susceptibility to autoimmune disorder J:163917
Cd19tm1(cre)Cgn/Cd19+
Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
involves: 129P2/OlaHsd 		decreased B-1a cell number J:175422
decreased B-1b cell number J:175422
decreased marginal zone B cell number J:175422
decreased mature B cell number J:175422
enlarged spleen J:175422
increased anti-nuclear antigen antibody level J:175422
increased B cell number J:175422
increased B cell proliferation J:175422
increased follicular B cell number J:175422
increased germinal center B cell number J:175422
increased IgA level J:175422
increased IgG2a level J:175422
increased IgM level J:175422
increased splenocyte number J:175422
increased T cell number J:175422
Gt(ROSA)26Sortm9(cre/ESR1)Arte/?
Tnfaip3tm1Homy/Tnfaip3tm1Homy
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac 		abnormal blood cell morphology/development J:212681
abnormal circulating cytokine level J:212681
abnormal circulating interleukin level J:212681
abnormal liver morphology J:212681
normal hematopoietic system phenotype J:212681
increased apoptosis J:212681
increased circulating interferon-gamma level J:212681
increased circulating interleukin-1 beta level J:212681
increased circulating interleukin-6 level J:212681
increased circulating tumor necrosis factor level J:212681
increased susceptibility to xenobiotic induced morbidity/mortality J:212681
pale spleen J:212681
thymus atrophy J:212681
Tnfaip3m1Apb/Tnfaip3m1Apb
C57BL/6-Tnfaip3m1Apb 		abnormal branching of the mammary ductal tree J:324062
abnormal estrous cycle J:324062
abnormal mammary gland development J:324062
abnormal mammary gland lobule morphology J:324062
CNS inflammation J:324062
decreased circulating luteinizing hormone level J:324062
decreased corpora lutea number J:324062
decreased fasting circulating glucose level J:324062
decreased secondary ovarian follicle number J:324062
delayed female fertility J:324062
enlarged lymph nodes J:324062
impaired mammary gland growth during pregnancy J:324062
increased circulating insulin level J:324062
increased circulating progesterone level J:324062
increased effector memory T-helper cell number J:324062
increased macrophage cell number J:324062
increased microglial cell activation J:324062
increased tumor necrosis factor (ligand) superfamily member 11 level J:324062
increased tumor necrosis factor receptor superfamily member 11b level J:324062
insulin resistance J:324062
prolonged diestrus J:324062
reduced female fertility J:324062
short estrus J:324062
uterus inflammation J:324062
Tnfaip3tm1.1Gho/Tnfaip3tm1.1Gho
involves: C57BL/6J 		enlarged spleen J:217021
normal immune system phenotype J:217021
increased myeloid cell number J:217021
increased myeloid cell number in bone marrow J:217021
Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl
Tg(Vil1-cre)997Gum/0
B6.Cg-Tnfaip3tm1.1Gvl Tg(Vil1-cre)997Gum 		abnormal response/metabolism to endogenous compounds J:163410
abnormal small intestine crypts of Lieberkuhn morphology J:163410
decreased colon length J:163410
diarrhea J:163410
impaired adaptive thermogenesis J:163410
increased circulating alanine transaminase level J:163410
increased circulating aspartate transaminase level J:163410
increased circulating interleukin-6 level J:163410
increased enterocyte apoptosis J:163410
increased susceptibility to induced colitis J:163410
increased susceptibility to induced morbidity/mortality J:163410
increased susceptibility to weight loss J:163410
increased susceptibility to xenobiotic induced morbidity/mortality J:163410
liver degeneration J:163410
rectal hemorrhage J:163410
Tnfaip3tm1Ama/Tnfaip3tm1Ama
involves: C57BL/6J 		abnormal cytokine secretion J:92694
abnormal inflammatory response J:92694
Tnfaip3tm1Ama/Tnfaip3tm1Ama
Not Specified 		decreased body size J:92931
increased granulocyte number J:92931
increased inflammatory response J:92931
increased lymphocyte cell number J:92931
increased macrophage cell number J:92931
increased susceptibility to induced morbidity/mortality J:92931
intestinal inflammation J:92931
joint inflammation J:92931
kidney inflammation J:92931
liver inflammation J:92931
postnatal lethality, incomplete penetrance J:92931
premature death J:92931
thick dermal layer J:92931
thick epidermis J:92931
Tnfaip3tm1Homy/Tnfaip3tm1Homy
Tg(Mx1-cre)1Cgn/?
involves: 129S6/SvEvTac * C57BL/6J * CBA/J 		abnormal B cell number J:212681
abnormal blood cell morphology/development J:212681
abnormal circulating cytokine level J:212681
abnormal circulating interleukin level J:212681
abnormal myelopoiesis J:212681
abnormal spleen morphology J:212681
anemia J:212681
cachexia J:212681
enlarged liver J:212681
enlarged lymph nodes J:212681
normal hematopoietic system phenotype J:212681
increased circulating interferon-gamma level J:212681
increased circulating interleukin-1 beta level J:212681
increased circulating interleukin-6 level J:212681
increased circulating tumor necrosis factor level J:212681
liver inflammation J:212681
lung inflammation J:212681
premature death J:212681
Tnfaip3tm2Ama/Tnfaip3tm2Ama
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell activation J:163917
abnormal B cell morphology J:163917
abnormal B-1a B cell morphology J:163917
decreased B cell apoptosis J:163917
decreased B cell number J:163917
increased autoantibody level J:163917
increased B cell number J:163917
increased B cell proliferation J:163917
increased germinal center B cell number J:163917
increased IgG level J:163917
increased IgM level J:163917
increased immature B cell number J:163917
increased immunoglobulin level J:163917
increased interleukin-6 secretion J:163917
increased plasma cell number J:163917
increased susceptibility to autoimmune disorder J:163917
increased T cell number J:163917
Tnfaip3tm3.1Ama/Tnfaip3tm3.1Ama
C57BL/6J-Tnfaip3tm3.1Ama 		abnormal chemokine secretion J:203160
decreased interleukin-6 secretion J:203160
enlarged spleen J:203160
normal growth/size/body region phenotype J:203160
increased B cell number J:203160
increased CD4-positive, alpha-beta T cell number J:203160
increased CD8-positive, alpha-beta T cell number J:203160
increased susceptibility to induced colitis J:203160
myeloid hyperplasia J:203160
Tnfaip3tm4.1Ama/Tnfaip3tm4.1Ama
C57BL/6J-Tnfaip3tm4.1Ama 		abnormal chemokine secretion J:203160
decreased interleukin-6 secretion J:203160
enlarged spleen J:203160
normal growth/size/body region phenotype J:203160
increased B cell number J:203160
increased CD4-positive, alpha-beta T cell number J:203160
increased CD8-positive, alpha-beta T cell number J:203160
increased susceptibility to induced colitis J:203160
myeloid hyperplasia J:203160
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory