Pole Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pole
polymerase (DNA directed), epsilon
MGI:1196391

5 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Mlh1^tm1Rak/Mlh1^tm1Rak Pole^tm1.1Bdp/Pole^tm1.1Bdp involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J	lethality during fetal growth through weaning, complete penetrance	J:153684
Msh2^tm1Rak/Msh2^tm1Rak Pole^tm1.1Bdp/Pole^tm1.1Bdp involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J	postnatal lethality, complete penetrance	J:153684
Pold1^tm1.1Bdp/Pold1^tm1.1Bdp Pole^tm1.1Bdp/Pole^tm1.1Bdp B6.129-Pole^tm1.1Bdp Pold1^tm1.1Bdp	increased skin tumor incidence	J:153684
	increased T cell derived lymphoma incidence	J:153684
	premature death	J:153684

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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