Dsg2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dsg2
desmoglein 2
MGI:1196466

42 phenotypes from 9 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dsg2^em1Spin/Dsg2⁺ involves: C57BL/6J	abnormal heart right ventricle wall morphology	J:342765
	abnormal intercalated disk morphology	J:342765
	abnormal QRS complex	J:342765
	cardiac fibrosis	J:342765
	decreased keratinocyte adhesion	J:342765
	decreased QRS amplitude	J:342765
	decreased right ventricle systolic pressure	J:342765
	irregular heartbeat	J:342765
	ventricular premature beat	J:342765
Dsg2^em1Spin/Dsg2^em1Spin involves: C57BL/6J	abnormal cardiovascular development	J:342765
	abnormal cell adhesion	J:342765
	abnormal heart left ventricle wall morphology	J:342765
	abnormal heart right ventricle wall morphology	J:342765
	abnormal heart ventricle morphology	J:342765
	abnormal intercalated disk morphology	J:342765
	abnormal QRS complex	J:342765
	cardiac fibrosis	J:342765
	cardiac hypertrophy	J:342765
	decreased heart ventricle muscle contractility	J:342765
	decreased keratinocyte adhesion	J:342765
	decreased left ventricle systolic pressure	J:342765
	decreased QRS amplitude	J:342765
	decreased right ventricle systolic pressure	J:342765
	embryonic lethality during organogenesis, incomplete penetrance	J:342765
	hemopericardium	J:342765
	irregular heartbeat	J:342765
	ventricular premature beat	J:342765
Dsg2^m1Btlr/Dsg2^m1Btlr C57BL/6J-Dsg2^m1Btlr	increased susceptibility to induced colitis	J:271975
Dsg2^m2Btlr/Dsg2^m2Btlr C57BL/6J-Dsg2^m2Btlr	increased susceptibility to induced colitis	J:271976
Dsg2^m3Btlr/Dsg2^m3Btlr C57BL/6J-Dsg2^m3Btlr	increased susceptibility to induced colitis	J:271977
Dsg2^{tm1a(EUCOMM)Wtsi}/Dsg2^{tm1a(EUCOMM)Wtsi} C57BL/6-Dsg2^{tm1a(EUCOMM)Wtsi}	cardiomyopathy	J:235770
Dsg2^{tm1b(EUCOMM)Wtsi}/Dsg2^{tm1b(EUCOMM)Wtsi} C57BL/6N-Dsg2^{tm1b(EUCOMM)Wtsi}/Bay	abnormal coat appearance	J:211773
	decreased cardiac muscle contractility	J:211773
	dilated heart left ventricle	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺ involves: C57BL/6J * C57BL/6N	abnormal heart electrocardiography waveform feature	J:235770
Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺ involves: C57BL/6J * C57BL/6N	normal cardiovascular system phenotype	J:235770
Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2^{tm1d(EUCOMM)Wtsi} involves: C57BL/6J * C57BL/6N	abnormal heart echocardiography feature	J:235770
	abnormal S wave	J:235770
	cardiac fibrosis	J:235770
	cardiomyopathy	J:235770
	decreased cardiac muscle contractility	J:235770
	decreased P wave amplitude	J:235770
	heart inflammation	J:235770
	increased cardiomyocyte apoptosis	J:235770
	increased Q wave amplitude	J:235770
	increased susceptibility to induced morbidity/mortality	J:235770
	prolonged QRS complex duration	J:235770
	ventricular premature beat	J:235770
Dsg2^tm1Leu/Dsg2⁺ either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	embryonic lethality between implantation and somite formation, incomplete penetrance	J:102536
Dsg2^tm1Leu/Dsg2^tm1Leu either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal cell death	J:102536
	decreased fibroblast proliferation	J:102536
	embryonic lethality at implantation, complete penetrance	J:102536
Dsg2^tm3.1Leu/Dsg2^tm3.1Leu Tg(Vil1-cre)20Syr/0 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2	abnormal intestinal epithelium morphology	J:302333
	normal digestive/alimentary phenotype	J:302333
	normal growth/size/body region phenotype	J:302333
	increased susceptibility to colitis induced morbidity/mortality	J:302333
	increased susceptibility to induced colitis	J:302333

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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