Birc2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Birc2
baculoviral IAP repeat-containing 2
MGI:1197009

21 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr involves: BALB/cJ * C57BL/6 * SJL	abnormal heart atrium morphology	J:182515
	congestive heart failure	J:182515
	decreased cardiac muscle contractility	J:182515
	embryonic lethality during organogenesis, complete penetrance	J:182515
	enlarged pericardium	J:182515
	hemopericardium	J:182515
	hemorrhage	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺ involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL	lethality throughout fetal growth and development, complete penetrance	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL	embryonic lethality during organogenesis, complete penetrance	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk3^tm1Vmd/Ripk3⁺ involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	embryonic lethality during organogenesis, complete penetrance	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk3^tm1Vmd/Ripk3^tm1Vmd involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	lethality throughout fetal growth and development, complete penetrance	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx involves: BALB/cJ * C57BL/6 * SJL	postnatal lethality, complete penetrance	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 * SJL	embryonic lethality during organogenesis, complete penetrance	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1Rbr/Birc3^tm1Rbr involves: BALB/cJ * C57BL/6	no abnormal phenotype detected	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺ Xiap^tm1Vdr/Xiap^tm1Vdr involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6	decreased body size	J:182515
	postnatal lethality, incomplete penetrance	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led Xiap^tm1Vdr/Xiap^tm1Vdr involves: 129S1/Sv * 129S6/SvEvTac * BALB/cJ * C57BL/6	lethality throughout fetal growth and development, complete penetrance	J:182515
Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Xiap^tm1Vdr/Xiap^tm1Vdr involves: 129S1/Sv * BALB/cJ * C57BL/6	abnormal heart atrium morphology	J:182515
	congestive heart failure	J:182515
	decreased cardiac muscle contractility	J:182515
	embryonic lethality during organogenesis, complete penetrance	J:182515
	enlarged pericardium	J:182515
	hemopericardium	J:182515
	hemorrhage	J:182515
Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr involves: C57BL/6 * NZB	normal immune system phenotype	J:172843
Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr involves: C57BL/6 * SJL	no abnormal phenotype detected	J:182515
Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Cd19^tm1(cre)Cgn/Cd19⁺ involves: 129P2/OlaHsd * C57BL/6 * NZB	decreased B cell apoptosis	J:172843
	decreased germinal center B cell number	J:172843
	decreased spleen germinal center size	J:172843
	enlarged lymph nodes	J:172843
	enlarged spleen	J:172843
	increased B cell number	J:172843
	increased follicular B cell number	J:172843
	increased marginal zone B cell number	J:172843
Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Cd19^tm1(cre)Cgn/Cd19⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass involves: 129P2/OlaHsd * C57BL/6 * NZB	normal immune system phenotype	J:172843
Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1Rbr/Birc3^tm1Rbr involves: C57BL/6	no abnormal phenotype detected	J:182515
Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1Rbr/Birc3^tm1Rbr Cd19^tm1(cre)Cgn/Cd19⁺ involves: 129P2/OlaHsd * C57BL/6 * NZB	normal immune system phenotype	J:172843

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24