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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rasa3
RAS p21 protein activator 3
MGI:1197013
71 phenotypes from 7 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Eportm1.1(EGFP/icre)Uk/Epor+
Rasa3tm1.1Llp/Rasa3tm1.1Llp
involves: 129S1/SvImJ * BALB/cJ * C57BL/6J 		normal hematopoietic system phenotype J:301035
Eportm1.1(EGFP/icre)Uk/Epor+
Rasa3tm1.1Llp/Rasa3tm1.3Llp
involves: 129S1/SvImJ * BALB/cJ * C57BL/6J 		normal hematopoietic system phenotype J:301035
Rasa3hlb381/?
C57BL/6J-Rasa3hlb381/J 		thrombocytopenia J:82961
Rasa3hlb381/Rasa3hlb381
C57BL/6J-Rasa3hlb381/J 		abnormal platelet physiology J:221899
decreased leukocyte cell number J:221899, J:301035
enlarged spleen J:221899
increased mean platelet volume J:221899
increased megakaryocyte cell number J:221899
increased spleen weight J:301035
normal mortality/aging J:221899
reticulocytosis J:301035
thrombocytopenia J:221899, J:301035
Rasa3scat/Rasa3+
involves: BALB/cBy 		maternal effect J:14198
Rasa3scat/Rasa3scat
B6.CBy-Rasa3scat/Llp 		embryonic lethality, complete penetrance J:301035
Rasa3scat/Rasa3scat
involves: BALB/cBy 		abnormal erythropoiesis J:186485
abnormal megakaryocyte differentiation J:186485
abnormal megakaryocyte morphology J:186485
abnormal pregnancy J:10670
abnormal spleen morphology J:186485
anemia J:186485
anisocytosis J:186485
bruising J:10670, J:186485
decreased B cell number J:186485
decreased birth body size J:186485
decreased bone marrow cell number J:186485
decreased CD4-positive, alpha-beta T cell number J:186485
decreased CD8-positive, alpha-beta T cell number J:186485
decreased leukocyte cell number J:186485
decreased mean corpuscular hemoglobin J:186485
decreased T cell number J:186485
enlarged spleen J:186485
hemolysis J:186485
hyperlipidemia J:186485
increased circulating bilirubin level J:186485
increased megakaryocyte cell number J:186485
increased spleen red pulp amount J:186485
internal hemorrhage J:10670
maternal effect J:14198
pale spleen J:186485
pallor J:10670, J:186485
petechiae J:10670
poikilocytosis J:186485
polychromatophilia J:186485
premature death J:10670
prenatal lethality, incomplete penetrance J:14198, J:186485
preweaning lethality, incomplete penetrance J:10670
reticulocytosis J:186485
thrombocytopenia J:186485
Rasa3scat/Rasa3scat
involves: BALB/cBy * BALB/cByJ 		abnormal cell cycle checkpoint function J:281271
abnormal erythroblast morphology J:281271
abnormal erythropoiesis J:281271
decreased apoptosis J:281271
decreased erythrocyte cell number J:301035
decreased hematocrit J:301035
decreased hemoglobin content J:301035
decreased leukocyte cell number J:301035
decreased mean corpuscular hemoglobin concentration J:301035
increased hemoglobin concentration distribution width J:301035
increased mean corpuscular volume J:301035
increased mean platelet volume J:301035
increased red blood cell distribution width J:301035
increased spleen weight J:301035
oxidative stress J:281271
reticulocytosis J:301035
thrombocytopenia J:301035
Rasa3tm1.1Llp/Rasa3tm1.1Llp
Tg(Mx1-cre)1Cgn/?
involves: 129S1/SvImJ * C57BL/6J * CBA/J 		abnormal erythropoiesis J:301035
anemia J:301035
anisocytosis J:301035
bone marrow failure J:301035
decreased erythrocyte cell number J:301035
decreased hematocrit J:301035
decreased hemoglobin content J:301035
decreased leukocyte cell number J:301035
hemolysis J:301035
increased circulating bilirubin level J:301035
increased circulating lactate dehydrogenase level J:301035
increased mean corpuscular volume J:301035
increased mean platelet volume J:301035
increased megakaryocyte-erythroid progenitor cell number J:301035
increased red blood cell distribution width J:301035
increased spleen weight J:301035
pancytopenia J:301035
poikilocytosis J:301035
reticulocytosis J:301035
thrombocytopenia J:301035
Rasa3tm1.1Llp/Rasa3tm1.1Llp
Tg(Tek-cre)1Ywa/?
involves: 129S1/SvImJ * C57BL/6J * SJL/J 		abnormal embryonic hematopoiesis J:301035
embryonic lethality prior to tooth bud stage J:301035
hemorrhage J:301035
Rasa3tm1.1Llp/Rasa3tm1.1Llp
Tg(Vav1-cre)1Cgp/?
involves: 129S1/SvImJ * C57BL/6J 		abnormal embryonic hematopoiesis J:301035
embryonic lethality prior to tooth bud stage J:301035
hemorrhage J:301035
Rasa3tm1.1Llp/Rasa3tm1.3Llp
Tg(CMV-cre)1Cgn/?
involves: 129S1/SvImJ * BALB/cJ * C57BL/6J 		embryonic lethality, complete penetrance J:301035
Rasa3tm1a(KOMP)J/Rasa3tm1a(KOMP)J
Tg(CMV-cre)1Cgn/?
(C57BL/6N-Rasa3tm1a(KOMP)J/J x B6.C-Tg(CMV-cre)1Cgn/J)F2 		embryonic lethality, complete penetrance J:301035
hemorrhage J:301035
pale liver J:301035
pallor J:301035
Rasa3tm1b(KOMP)J/Rasa3+
C57BL/6N-Rasa3tm1b(KOMP)J/J 		abnormal sleep behavior J:211773
decreased circulating glucose level J:211773
decreased exploration in new environment J:211773
increased heart weight J:211773
Rasa3tm1b(KOMP)J/Rasa3tm1b(KOMP)J
C57BL/6N-Rasa3tm1b(KOMP)J/J 		abnormal forebrain morphology J:211773
abnormal midbrain morphology J:211773
hemorrhage J:211773
prenatal lethality prior to heart atrial septation J:211773
preweaning lethality, complete penetrance J:211773
Rasa3tm1Shiw/Rasa3tm1Shiw
Not Specified 		abnormal embryo development J:120930
abnormal vascular endothelial cell development J:120930
edema J:120930
hemorrhage J:120930
lethality throughout fetal growth and development, complete penetrance J:120930
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory