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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bcl2l11
BCL2 like 11
MGI:1197519
85 phenotypes from 14 alleles in 19 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bcl2l11em1(IMPC)H/Bcl2l11em1(IMPC)H
C57BL/6NTac-Bcl2l11em1(IMPC)H/H 		decreased mean corpuscular hemoglobin J:211773
decreased total body fat amount J:211773
increased circulating potassium level J:211773
increased erythrocyte cell number J:211773
increased grip strength J:211773
increased large unstained cell number J:211773
increased leukocyte cell number J:211773
increased lymphocyte cell number J:211773
increased spleen weight J:211773
Bcl2l11tm1.1Ast/Bcl2l11+
B6.129S1-Bcl2l11tm1.1Ast 		normal immune system phenotype J:153846
increased leukocyte cell number J:153846
increased spleen weight J:153846
Bcl2l11tm1.1Ast/Bcl2l11+
involves: 129S1/Sv * C57BL/6 		abnormal lymphocyte physiology J:58641
glomerulonephritis J:58641
increased IgA level J:58641
increased IgG level J:58641
increased IgM level J:58641
increased susceptibility to autoimmune disorder J:58641
premature death J:58641
renal glomerular immunoglobulin deposits J:58641
vascular inflammation J:58641
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
B6.129-Bcl2l11tm1.1Ast/J 		decreased lymphocyte cell number J:137609
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
B6.129S1-Bcl2l11tm1.1Ast 		abnormal B cell morphology J:133084
abnormal leukopoiesis J:73316
abnormal lymphocyte physiology J:73316
abnormal NK cell morphology J:123409
abnormal response to infection J:123409
abnormal sympathetic neuron morphology J:124044
decreased apoptosis J:123409
decreased B cell apoptosis J:73316
decreased physiological sensitivity to xenobiotic J:123409
decreased T cell apoptosis J:73316, J:133084
normal immune system phenotype J:153846
increased immature B cell number J:133084
increased leukocyte cell number J:153846
increased mature B cell number J:133084
increased NK cell number J:123409
increased regulatory T cell number J:208318
increased spleen weight J:153846
increased transitional stage B cell number J:133084
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
B6.129S1-Bcl2l11tm1.1Ast/J 		decreased T cell apoptosis J:153652
increased B cell number J:153652
increased CD4-positive, alpha-beta T cell number J:153652
increased CD8-positive, alpha-beta T cell number J:153652
increased splenocyte number J:153652
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
involves: 129S1/Sv 		abnormal CD4-positive, alpha-beta T cell number J:132819
abnormal CD8-positive, alpha-beta T cell physiology J:132819
abnormal involution of the mammary gland J:235354
abnormal splenic cell ratio J:132819
decreased splenocyte apoptosis J:266833
decreased thymocyte apoptosis J:266833
normal hematopoietic system phenotype J:141545
increased B cell number J:132819
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
involves: 129S1/Sv * C57BL/6 		abnormal B cell proliferation J:90963
abnormal kidney morphology J:132217
abnormal lymphocyte physiology J:58641
abnormal plasma cell morphology J:58641
abnormal renal glomerulus basement membrane morphology J:132217
abnormal renal glomerulus morphology J:58641
abnormal spleen morphology J:58641
abnormal splenic cell ratio J:132217
decreased B cell apoptosis J:90963
decreased double-positive T cell number J:58641
dilated renal tubule J:58641
embryonic lethality during organogenesis, incomplete penetrance J:58641
enlarged spleen J:58641
expanded mesangial matrix J:58641
glomerular crescent J:58641
glomerulonephritis J:58641
increased anti-double stranded DNA antibody level J:132217
increased anti-histone antibody level J:132217
increased anti-nuclear antigen antibody level J:132217
increased anti-single stranded DNA antibody level J:132217
increased autoantibody level J:132217
increased B cell number J:58641
increased blood urea nitrogen level J:58641
increased CD4-positive, alpha-beta T cell number J:58641
increased CD8-positive, alpha-beta T cell number J:58641
increased double-negative T cell number J:58641
increased follicular B cell number J:132217
increased granulocyte number J:58641
increased IgA level J:58641
increased IgG level J:58641
increased IgM level J:58641
increased immature B cell number J:132217
increased inflammatory response J:58641
increased leukocyte cell number J:58641
increased marginal zone B cell number J:132217
increased monocyte cell number J:58641
increased renal glomerulus apoptosis J:132217
increased splenocyte number J:132217
increased susceptibility to autoimmune disorder J:58641
increased T cell number J:58641
increased transitional stage B cell number J:132217
normal nervous system phenotype J:127640
premature death J:58641
renal cast J:58641
renal glomerular immunoglobulin deposits J:58641
spleen hyperplasia J:58641
thrombocytopenia J:58641
vascular inflammation J:58641
Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui
C57BL/6-Bcl2l11tm1.1Boui 		normal immune system phenotype J:153846
increased leukocyte cell number J:153846
increased spleen weight J:153846
Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
C57BL/6-Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui 		normal immune system phenotype J:153846
increased leukocyte cell number J:153846
increased spleen weight J:153846
Bcl2l11tm1.1Jad/Bcl2l11+
Not Specified 		no abnormal phenotype detected J:73316
Bcl2l11tm1.1Jad/Bcl2l11tm1.1Jad
involves: C57BL/6 		abnormal mammary gland development J:104975
abnormal mammary gland duct morphology J:104975
Bcl2l11tm1Ast/Bcl2l11tm1Ast
B6.129S1-Bcl2l11tm1Ast 		abnormal hippocampus morphology J:111236
gliosis J:111236
Bcl2l11tm1Sjk/Bcl2l11tm1Sjk
involves: 129X1/SvJ 		abnormal B cell physiology J:100463
abnormal spleen marginal zone morphology J:100463
increased B cell number J:100463
increased B-2 B cell number J:100463
increased follicular B cell number J:100463
increased immunoglobulin level J:100463
increased transitional stage B cell number J:100463
Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui
C57BL/6-Bcl2l11tm2.1Boui 		normal immune system phenotype J:153846
increased leukocyte cell number J:153846
increased spleen weight J:153846
Bcl2l11tm2Rjd/Bcl2l11tm2Rjd
B6.129S6-Bcl2l11tm2Rjd 		increased fibroblast apoptosis J:137061
Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
C57BL/6-Bcl2l11tm3.1Boui 		normal immune system phenotype J:153846
increased leukocyte cell number J:153846
increased spleen weight J:153846
Bcl2l11tm3Rjd/Bcl2l11tm3Rjd
B6.129S6-Bcl2l11tm3Rjd 		decreased thymocyte apoptosis J:137061
increased B cell number J:153652
increased CD4-positive, alpha-beta T cell number J:153652
increased CD8-positive, alpha-beta T cell number J:153652
increased splenocyte number J:153652
Bcl2l11tm4Boul/Bcl2l11tm4Boul
involves: C57BL/6 		normal hematopoietic system phenotype J:203181
normal immune system phenotype J:203181
Bcl2l11tm4Rjd/Bcl2l11tm4Rjd
B6.129S6-Bcl2l11tm4Rjd 		increased fibroblast apoptosis J:137061
Bcl2l11tm4Rjd/Bcl2l11tm4Rjd
involves: 129S6/SvEvTac * C57BL/6 		normal hematopoietic system phenotype J:203181
normal immune system phenotype J:203181
Bcl2l11tm5Boul/Bcl2l11tm5Boul
involves: C57BL/6 		normal hematopoietic system phenotype J:203181
normal immune system phenotype J:203181
Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		increased regulatory T cell number J:208318
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory