Top3a Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Top3a
topoisomerase (DNA) III alpha
MGI:1197527

5 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Top3a^{tm1b(EUCOMM)Hmgu}/Top3a⁺ C57BL/6N-Top3a^{tm1b(EUCOMM)Hmgu}/J	impaired pupillary reflex	J:211773
Top3a^{tm1b(EUCOMM)Hmgu}/Top3a^{tm1b(EUCOMM)Hmgu} C57BL/6N-Top3a^{tm1b(EUCOMM)Hmgu}/J	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Top3a^tm1Jcw/Top3a^tm1Jcw involves: 129S6/SvEvTac * C57BL/6	abnormal inner cell mass proliferation	J:45652
Top3a^tm1Jcw/Top3a^tm1Jcw involves: 129S6/SvEvTac * C57BL/6	embryonic lethality between implantation and somite formation, complete penetrance	J:45652

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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